Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells.

Abstract:

:In order to investigate the global and dynamic host microRNAs (miRNAs)/messenger RNAs (mRNAs) expression alteration during in vitro acute HCV infection, a comprehensive microarray analysis was performed using human hepatoma cells. Totally, 108 human miRNAs and 1247 mRNAs were identified whose expression levels changed for more than 2.0-fold in response to HCV infection. Upon HCV infection, signature from the unique miRNA expression pattern reflected the involvement of miRNA-regulated host cellular physiology and antiviral mechanism, whereas a preponderance of differentially regulated genes associated with metabolism, cell growth, apoptosis and cytokine/chemokine pathways. Furthermore, a reverse regulatory association of differentially expressed miRNAs and their predicted targets was constructed. Finally, the differentially expressed miRNAs such as miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation. These results suggest that combined miRNA and mRNA profiling may have superior potential as a diagnostic and mechanistic feature in HCV infection.

journal_name

Virology

journal_title

Virology

authors

Liu X,Wang T,Wakita T,Yang W

doi

10.1016/j.virol.2009.11.036

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

57-67

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(09)00772-7

journal_volume

398

pub_type

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