The evolution of porcine reproductive and respiratory syndrome virus: quasispecies and emergence of a virus subpopulation during infection of pigs with VR-2332.

abstract：:The emergence and re-emergence of Zika virus (ZIKV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas worldwide. Despite these burdens, antiviral therapies do not exist, and inhibitors of ZIKV are therefore urgently needed. To...

journal_title：Virology

authors： Chen H,Lao Z,Xu J,Li Z,Long H,Li D,Lin L,Liu X,Yu L,Liu W,Li G,Wu J

更新日期：2020-07-01 00:00:00

abstract：:The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potenc...

journal_title：Virology

authors： Bates JT,Keefer CJ,Slaughter JC,Kulp DW,Schief WR,Crowe JE Jr

更新日期：2014-04-01 00:00:00

abstract：:Two mutant strains of cucumber mosaic virus (CMV) were investigated with respect to virion stability and molecular determinants of aphid vector transmission. The mutant 2A1-MT-60x, derived from the mechanically passaged wild type 2A1-AT, is poorly transmissible by the aphid Aphis gossypii and not transmissible by the ...

journal_title：Virology

authors： Ng JC,Liu S,Perry KL

更新日期：2000-10-25 00:00:00

abstract：:We assess the genetic relationships between 49 HIV-1 group O strains from 24 and 25 patients living in Cameroon and France, respectively. Strains were sequenced in four genomic regions: gag (p24) and three env regions (C2-V3, gp41, and for 22 C2-gp41). In each of the genomic regions analyzed, the genetic diversity amo...

journal_title：Virology

authors： Roques P,Robertson DL,Souquière S,Damond F,Ayouba A,Farfara I,Depienne C,Nerrienet E,Dormont D,Brun-Vézinet F,Simon F,Mauclère P

更新日期：2002-10-25 00:00:00

abstract：:We have determined the nucleotide sequence of the RNA2 segment of the Nudaurelia capensis omega virus genome. It was found to consist of 2448 nucleotides and contained one long open reading frame (ORF) encoding the 644 residue capsid protein. The deduced amino acid sequence of this protein reveals a positively charged...

journal_title：Virology

authors： Agrawal DK,Johnson JE

更新日期：1992-10-01 00:00:00

abstract：:Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) is an orphan nuclear receptor that represses transcription of many genes. In adenovirus type 12 (Ad12) transformed cells, a high level of binding activity of COUP-TF to the major histocompatibility complex (MHC) class I enhancer correlates with the dow...

journal_title：Virology

authors： Smirnov DA,Hou S,Ricciardi RP

更新日期：2000-03-15 00:00:00

abstract：:We have cloned an infectious genome of the Junonia coenia densonucleosis virus (JcDNV) into the bacterial plasmid pBR322. The viral genome could be rescued from the recombinant plasmid pBRJ by transfection of pBRJ DNA to sensitive Spodoptera littoralis larvae. pBRJ DNA produced a typical viral infection and a comparab...

journal_title：Virology

authors： Jourdan M,Jousset FX,Gervais M,Skory S,Bergoin M,Dumas B

更新日期：1990-11-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) has been causally linked to Kaposi's sarcoma (KS). There is significant homology between some HHV-8 genes and cellular genes including D-type cyclin (vCYC), G protein coupled receptor (vGCR), macrophage inflammatory proteins (vMIP-I, vMIP-II), bcl-2 (vBCL2), interferon regulatory factor-1 (...

journal_title：Virology

authors： Yen-Moore A,Hudnall SD,Rady PL,Wagner RF Jr,Moore TO,Memar O,Hughes TK,Tyring SK

更新日期：2000-02-15 00:00:00

abstract：:We have previously described a selective increase in HIV-DNA content in CCR5-negative lymphocytes from late stage HIV-infected patients. Here, we show that this increase occurred even in the absence of viral phenotypic switching from CCR5- to CXCR4-tropic. This leads us to hypothesize that early and late CCR5-tropic v...

journal_title：Virology

authors： Pakarasang M,Wasi C,Suwanagool S,Chalermchockcharoenkit A,Auewarakul P

更新日期：2006-04-10 00:00:00

abstract：:Mixed infection of nonpermissive bacteria by amber mutant and wild-type T4 phage reduces the burst size in a manner that depends on the nature of the gene product eliminated by the mutation. While the genotypic proportions produced by such mixedly infected cells were directly proportional to those in the starting mixt...

journal_title：Virology

authors： Eiserling FA,Fluck M,Epstein RH

更新日期：1984-08-01 00:00:00

abstract：:The virus SIRV1 of the extremely thermophilic archaeon Sulfolobus has a double-stranded DNA genome similar in architecture to the genomes of eukaryal viruses of the families Poxviridae, Pycodnaviridae, and Asfarviridae: the two strands of the 32,301 bp long linear genome are covalently connected forming a continuous p...

journal_title：Virology

authors： Blum H,Zillig W,Mallok S,Domdey H,Prangishvili D

更新日期：2001-03-01 00:00:00

abstract：:The existence and genetic make-up of most primate retroviruses was revealed by studies of bushmeat and fecal samples from unhabituated primate communities. For these, detailed data on intra- and within-species contact rates are generally missing, which makes identification of factors influencing transmission a challen...

journal_title：Virology

authors： Gogarten JF,Akoua-Koffi C,Calvignac-Spencer S,Leendertz SA,Weiss S,Couacy-Hymann E,Koné I,Peeters M,Wittig RM,Boesch C,Hahn BH,Leendertz FH

更新日期：2014-07-01 00:00:00

abstract：:Mouse hepatitis virus (MHV) JHMV and its soluble receptor-resistant (srr) mutants, srr7, srr11, and srr18, grew and induced syncytia equally well in BHK-R1 cells expressing the MHVR1 receptor derived from MHV-susceptible BALB/c mice. In contrast, srr growth and syncytia formations were drastically reduced relative to ...

journal_title：Virology

authors： Matsuyama S,Taguchi F

更新日期：2000-07-20 00:00:00

abstract：:Seven structural component proteins of a paramyxovirus simian virus 41 (SV41) were identified with the aid of monoclonal antibodies prepared against SV41 and human parainfluenza type 2 virus (PIV2). The nucleoprotein is antigenically very close to that of PIV2, while it is comparatively far from that of simian virus 5...

journal_title：Virology

authors： Tsurudome M,Bando H,Nishio M,Iwamoto Y,Kawano M,Kondo K,Komada H,Ito Y

更新日期：1990-12-01 00:00:00

abstract：:Cytoplasmic tails of envelope (Env) glycoproteins of many retroviruses inhibit their membrane fusion activity. The cytoplasmic 16-amino acid peptide of ecotropic murine leukemia virus (E-MLV) Env protein, called the R-peptide, also inhibits the membrane fusion activity of the Env protein. However, the molecular mechan...

journal_title：Virology

authors： Kubo Y,Izumida M,Togawa K,Zhang F,Hayashi H

更新日期：2019-06-01 00:00:00

abstract：:A mouse model system for a lethal encephalitis due to influenza has been established by stereotaxic microinjection with the recombinant R404BP strain of influenza A virus into the olfactory bulb of C57BL/6 mice. The virus infection spread selectively to neurons in nuclei of the broad areas of the brain parenchyma that...

journal_title：Virology

authors： Mori I,Liu B,Hossain MJ,Takakuwa H,Daikoku T,Nishiyama Y,Naiki H,Matsumoto K,Yokochi T,Kimura Y

更新日期：2002-11-25 00:00:00

abstract：:The genome of the Trichoplusia ni single nucleopolyhedrovirus (TnSNPV), a group II NPV which infects the cabbage looper (T. ni), has been completely sequenced and analyzed. The TnSNPV DNA genome consists of 134,394 bp and has an overall G + C content of 39%. Gene analysis predicted 144 open reading frames (ORFs) of 15...

journal_title：Virology

authors： Willis LG,Seipp R,Stewart TM,Erlandson MA,Theilmann DA

更新日期：2005-08-01 00:00:00

abstract：:Among 167 rotavirus specimens collected from young children in a suburban area of Bissau, Guinea-Bissau, from 1996 to 1998, most identifiable strains belonged to the uncommon P[6], G2 type and approximately 50% remained incompletely typed. In the present study, 76 such strains were further characterized. Due to interp...

journal_title：Virology

authors： Fischer TK,Page NA,Griffin DD,Eugen-Olsen J,Pedersen AG,Valentiner-Branth P,Mølbak K,Sommerfelt H,Nielsen NM

更新日期：2003-06-20 00:00:00

abstract：:In this study, we present enzymatic differences found between recombinant RTs derived from feline leukemia virus and feline immunodeficiency virus. Firstly, FIV RT showed low steady state K(m) values for dNTPs compared to FeLV RT. Consistent with this, FIV RT synthesized DNA more efficiently than FeLV RT at low dNTP c...

journal_title：Virology

authors： Operario DJ,Reynolds HM,Kim B

更新日期：2005-04-25 00:00:00

abstract：:To address the mechanisms of host-virus adaptation and pathogenesis of lentiviral infections, we compared the evolution of the same isolate of simian immunodeficiency virus (SIVsmm9) in two different situations: nonpathogenic infection of its natural host, the sooty mangabey, and AIDS-inducing infection of a new host,...

journal_title：Virology

authors： Courgnaud V,Saurin W,Villinger F,Sonigo P

更新日期：1998-07-20 00:00:00

abstract：:Early region 1 (E1) of the human adenoviruses has many intriguing properties which have prompted numerous mutational studies to help delineate and characterize the domains responsible for these functions. In mutational analyses being done currently, the E1 region is usually cloned into a bacterial plasmid where it is ...

journal_title：Virology

authors： McGrory WJ,Bautista DS,Graham FL

更新日期：1988-04-01 00:00:00

abstract：:The biological significance of protective CD8 T-cell-mediated responses against non-traditional alternative reading frame epitopes remains relatively unknown. Cytolytic CD8 T cells (CTL) specific for a non-traditional cryptic MHC class I epitope, SYNTGRFPPL, are critically involved in the protection of mice during inf...

journal_title：Virology

authors： Rutkowski MR,Ho O,Green WR

更新日期：2009-08-01 00:00:00

abstract：:Previously we have reported that the essential 3a movement gene of icosahedral cowpea chlorotic mottle virus (CCMV) can be functionally replaced by the 30-kDa movement gene of rod-shaped sunn-hemp mosaic virus (SHMV). Because plant RNA viruses differ in requiring or not requiring coat protein for systemic infection, w...

journal_title：Virology

authors： De Jong W,Mise K,Chu A,Ahlquist P

更新日期：1997-05-26 00:00:00

abstract：:Plasmid p12929 was shown to integrate into the chromosome of Corynebacterium glutamicum RM3 and BL15. The minimal integrating fragment was subsequently defined. The arms flanking the integrated plasmid (attL and attR) were identified, allowing for the determination of the attP and the attB attachment sites. The attB s...

journal_title：Virology

authors： Moreau S,Le Marrec C,Blanco C,Trautwetter A

更新日期：1999-03-01 00:00:00

abstract：:The budded phenotype of Autograha californica nuclear polyhedrosis virus (AcNPV BV) has a 64K glycoprotein in its envelope which is important in the ability of the virus to functionally enter host cells. Tunicamycin (TM), an inhibitor of N-linked glycosylation, was used to determine whether the sugar moiety was essent...

journal_title：Virology

authors： Charlton CA,Volkman LE

更新日期：1986-10-15 00:00:00

abstract：:We mutagenized and characterized a 41-kilobase-pair subgenomic cloned fragment from the unique long (UL) region of pseudorabies virus (PRV). Forty mutant clones, each carrying a single inserted oligonucleotide, were used for cotransfection with overlapping cloned viral DNA fragments. More than half of these transfecti...

journal_title：Virology

authors： De Wind N,Peeters BP,Zuderveld A,Gielkens AL,Berns AJ,Kimman TG

更新日期：1994-05-01 00:00:00

abstract：:The group B noncultivatable rotavirus, ADRV, was purified from infected stool specimens. Double-stranded RNA was extracted, polyadenylated, reverse transcribed into cDNA, and cloned into plasmid vector pAT153. Each cDNA clone hybridized to a single ADRV RNA segment and cDNA clones of each genomic RNA segment were iden...

journal_title：Virology

authors： Chen GM,Hung T,Mackow ER

更新日期：1990-04-01 00:00:00

abstract：:Unusual Plum pox virus (PPV) isolates (named Tat isolates) were discovered on sour cherry (Prunus cerasus) in Russia. They failed to be recognized by RT-PCR using commonly employed primers specific to the strains C or CR (the only ones that proved able to infect sour cherry) as well as to the strains M and W. Some of ...

journal_title：Virology

authors： Chirkov S,Ivanov P,Sheveleva A,Zakubanskiy A,Osipov G

更新日期：2017-02-01 00:00:00

abstract：:Human papillomavirus (HPV) is a family of viruses divided into five genera: alpha, beta, gamma, mu, and nu. There is an ongoing discussion about whether beta genus HPVs (β-HPVs) contribute to cutaneous squamous cell carcinoma (cSCC). The data presented here add to this conversation by determining how a β-HPV E6 protei...

journal_title：Virology

authors： Dacus D,Riforgiate E,Wallace NA

更新日期：2020-10-01 00:00:00

abstract：:Granulin and polyhedrin proteins were purified by preparative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis from the baculoviruses Autographa californica, Rachiplusia ou, Heliothis zea, Heliothis armigera, Trichoplusia ni, and Spodoptera frugiperda. Antisera were raised against Autographa californica...

journal_title：Virology

authors： Summers MD,Hoops P

更新日期：1980-05-01 00:00:00