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Increased HIV-DNA load in CCR5-negative lymphocytes without viral phenotypic change.

Abstract：

:We have previously described a selective increase in HIV-DNA content in CCR5-negative lymphocytes from late stage HIV-infected patients. Here, we show that this increase occurred even in the absence of viral phenotypic switching from CCR5- to CXCR4-tropic. This leads us to hypothesize that early and late CCR5-tropic viruses might be different in the ability to infect CCR5-low or -negative cells. We compared a set of early CCR5-tropic viruses with low viral DNA content in CCR5-negative cells to a set of late CCR5-tropic viruses with high viral DNA content in CCR5-negative cells. We could not find any significant differences between the two sets of viruses in the aspects of relative infectivity in CCR5-low cells and the level of inhibition by beta-chemokine. This suggested that there may be some changes in cellular phenotype or environment that allows an expansion of susceptible cell population in late stages HIV infection. Understanding these changes may provide a novel approach for HIV therapy.

journal_name

Virology

journal_title

Virology

authors

Pakarasang M,Wasi C,Suwanagool S,Chalermchockcharoenkit A,Auewarakul P

doi

10.1016/j.virol.2005.12.003

subject

Has Abstract

pub_date

2006-04-10 00:00:00

pages

372-8

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(05)00807-X

journal_volume

347

pub_type

杂志文章

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