Abstract:
:A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous chimpanzee provirus, CH2. DNA sequencing within the clone and comparisons with other retroviruses revealed that ERV3 contains gag and pol gene sequences that are significantly related to those of mammalian type C retroviruses and previously described human endogenous proviruses. The ERV3 genome was determined to reside at a single locus on human chromosome 7 using a panel of rodent X human somatic cell hybrids.
journal_name
Virologyjournal_title
Virologyauthors
O'Connell C,O'Brien S,Nash WG,Cohen Mdoi
10.1016/0042-6822(84)90347-7subject
Has Abstractpub_date
1984-10-30 00:00:00pages
225-35issue
2eissn
0042-6822issn
1096-0341journal_volume
138pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::The antigenic structure of the VP4 protein of human rotavirus (HRV) strains Wa and ST3 was studied by using a panel of Wa- and ST3-derived VP4-specific neutralizing monoclonal antibodies (NMAbs) and NMAb-resistant variants. The VP4-coding genes from three Wa and three ST3 variants were sequenced. For Wa VP4, one homot...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(95)80029-8
更新日期:1995-01-10 00:00:00
abstract::We reported earlier that variable expression of the Epstein-Barr virus (EBV) encoded membrane protein LMP 1 in nasopharyngeal carcinoma and the host-cell-phenotype-dependent activity of the BCR2 promoter (one of the possible initiator sites for transcripts of Epstein-Barr nuclear antigens) in Burkitt's lymphoma (BL) l...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1229
更新日期:1994-05-01 00:00:00
abstract::By employing two different buffer solutions for polyacrylamide gel electrophoresis, all genome segments of Fiji disease and maize rough dwarf virus were separated. Fiji disease virus contains ten genome segments with approximate genome molecular weights of 19.26 x 10(6) and 19.85 x 10(6), depending on the buffer emplo...
journal_title:Virology
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::HIV infects macrophages and microglia in the central nervous system (CNS). Mechanisms that enhance HIV macrophage/microglial tropism are not well understood. Here, we identify an HIV Env variant in the V4 region of gp120, Asp 386 (D386), that eliminates an N-linked glycosylation site at position 386, enhances viral re...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.05.029
更新日期:2007-10-10 00:00:00
abstract::We have applied the procedure of Agrobacterium-mediated inoculation to develop a simple, efficient, and reproducible assay for the infectivity of the leafhopper-transmitted geminivirus, beet curly top virus (BCTV). This assay system was used to show that a coat protein mutant of BCTV is not infectious, but could be co...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90205-5
更新日期:1989-10-01 00:00:00
abstract::Expression of adenosine deaminase acting on RNA1 (ADAR1) is driven by alternative promoters. Promoter PA, activated by interferon (IFN), produces transcripts that encode the inducible p150 ADAR1 protein, whereas PB specifies the constitutively expressed p110 protein. We show using Stat1(-/-), Stat2(-/-) and IRF9(-/-) ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.08.001
更新日期:2015-11-01 00:00:00
abstract::Sequence analysis of the mouse hepatitis virus, strain A59 (MHV-A59) genome predicts the presence of two papain-like proteinases encoded within the first open reading frame (ORF 1a) of the replicase gene. The more 5' of these domains, the leader papain-like proteinase, is responsible for the cleavage of the amino term...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1281
更新日期:1995-06-01 00:00:00
abstract::The rate of synthesis in vivo and the steady-state level of mRNA of four "model" herpes simplex virus type 1 (HSV-1) genes were measured as a function of high levels of alpha-gene products. The genes studied were ICP4 (alpha), deoxy-UTPase (beta), VP5 (beta gamma), and glycoprotein C (gC, gamma). Accumulation of high ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90318-7
更新日期:1987-03-01 00:00:00
abstract::Virus like particles (17 nm in diameter) associated with maize white line mosaic virus (MWLMV) were shown to be a satellite virus of MWLMV (SV-MWLMV) on the basis of the following properties: (1) The SV-MWLMV was dependent upon the presence of MWLMV for replication in maize, while the latter virus could replicate inde...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90060-o
更新日期:1991-02-01 00:00:00
abstract::The tegument of herpes simplex virus contains proteins important for the efficient initiation of infection. L-particles are noninfectious virion-related particles that lack the nucleocapsid but do contain tegument and envelope. Their ability to deliver functional proteins into cells was compared to that of virions by ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90906-6
更新日期:1992-10-01 00:00:00
abstract::A combination of linker scanning mutagenesis and deletional analyses has been used to determine the role of individual DNA-protein binding sites on expression from the hepatitis B virus (HBV) enhancer I-X promoter (map position (mp) 1042-1354, HBV adw2). Linker scanning mutation of the EF-C site caused a 67.5% drop in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1173
更新日期:1993-04-01 00:00:00
abstract::Infection with bovine papillomavirus type 1 (BPV1) or BPV2 induces fibropapillomas in cows and skin sarcoids in horses. Prophylactic vaccination targeting BPV1 and BPV2 may reduce the incidence of these economically important diseases. The L1 major capsid proteins of BPV1 and BPV2 were expressed in Sf-9 insect cells a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.07.036
更新日期:2009-10-10 00:00:00
abstract::During head assembly of phage T3, DNA is packaged into the cavity of a preformed protein shell, called the prohead, with the aid of noncapsid, packaging proteins, the products of genes 18 and 19 (gp18 and gp19). gp18 and gp19 separately form complexes with DNA and proheads, respectively. These complexes associate to f...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90550-u
更新日期:1991-12-01 00:00:00
abstract::It is well established that the human subgroup C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor suppressor, p53. However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear. To investigate this issue, we examined...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.06.016
更新日期:2008-09-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema accumulation and death. IL-1β driven proinflammation is associated with those pathological signatures,...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.08.010
更新日期:2015-11-01 00:00:00
abstract::We have constructed a recombinant baculovirus expressing high levels of the herpes simplex virus type 1 (HSV-1) glycoprotein E (gE) in Sf9 cells. The expressed gE migrated on gels as a double band with apparent molecular weights of 68 and 70 kDa. The recombinant gE was glycosylated based on its susceptibility to tunic...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90500-o
更新日期:1992-06-01 00:00:00
abstract::In order to establish whether the poor growth of the two fastidious adenoviruses types 40 and 41 (Ad40 and Ad41) in HeLa cells is due to a reduced trans-activation by the early region 1A (E1A), we have determined the trans-activating effect of this region on the expression of the chloramphenicol acetyltransferase (CAT...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90080-8
更新日期:1987-09-01 00:00:00
abstract::Bacteriophage P2 integrase (Int) mediates site-specific recombination leading to integration or excision of the phage genome in or out of the bacterial chromosome. Int belongs to the large family of tyrosine recombinases that have two different DNA recognition motifs binding to the arm and core sites, respectively, wh...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.11.015
更新日期:2005-02-05 00:00:00
abstract::While HPV 16 variant lineages have been well characterized, the knowledge about HPV 18 variants is limited. In this study, HPV 18 nucleotide variations in the E2 hinge region were characterized by sequence analysis in 47 control and 51 tumor specimens. Fifty of these specimens were randomly selected for sequencing of ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.04.022
更新日期:2005-07-20 00:00:00
abstract::The pr55gag polyprotein of HIV-1 plays a critical role in the formation of immature virus particles in the cell and during the budding process. We investigated the influence of amino acid substitutions in the p24CA- region of the gag polyprotein on the viral assembly process. Deletion of the amino acids 341-352 in the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1210
更新日期:1993-04-01 00:00:00
abstract::Several purified species of human leukocyte interferon, including recombinant interferons, inhibit the multiplication of tobacco mosaic virus (TMV) in tobacco protoplasts derived from various cultivars. Viral RNA accumulation was determined by dot-blot hybridization to specific cDNA probes, and virus antigen was deter...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90456-8
更新日期:1985-01-15 00:00:00
abstract::Nanogram amounts of the proinflammatory cytokine interleukin-1alpha (IL-1alpha) were detected in uninfected cultures of human corneal epithelial cells (HCEC). Although HSV-1 replicated >10(4)-fold in these cells and caused extensive cytopathic effects, virus infection was not accompanied by significant extracellular r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9084
更新日期:1998-04-25 00:00:00
abstract::Expansion of CHIKV outbreaks with appearance of novel mutations are reported from many parts of the world. Two novel mutations viz. E1:K211E and E2:V264A in background of E1:226A are recently identified from Aedes aegypti dominated areas of India. In this study, the role of these mutations in modulation of infectivity...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.06.025
更新日期:2016-10-01 00:00:00
abstract::Mouse hepatitis viruses (MHV) of different virulence for mice were studied with respect to interferon (IFN) sensitivity. The growth of low-virulent MHV-S and intermediately virulent MHV-JHM was significantly suppressed in IFN-treated L cells compared with untreated cells. However, a comparable suppression of the growt...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90225-9
更新日期:1985-11-01 00:00:00
abstract::Cytoplasmic poly(A)-containing RNA from parainfluenza virus 3-infected cells was used as template to construct a cDNA library that was cloned into the EcoRV site of the plasmid pMG5. The resulting clones were screened with [32P]-labeled cDNA probes made from infected and mock-infected cell mRNAs. The virus specificity...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90237-5
更新日期:1985-11-01 00:00:00
abstract::Sixteen monoclonal antibodies directed to the hemagglutinin-neuraminidase (HN) protein of a 1957 isolate of parainfluenza type 3 virus (PIV3) were produced and used to examine antigenic variation in clinical strains. Analysis of hemagglutination-inhibition reactivity patterns of antigenic variants selected in vitro in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90395-2
更新日期:1985-06-01 00:00:00
abstract::Serial passage of Ross River virus in chick embryo fibroblasts selected for virus variants altered in their reactions to neutralizing monoclonal antibodies. The E1 and E2 genes of each antigenic variant were sequenced; single nucleotide changes were found in E2 leading to amino acid substitutions at either residue 4 (...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1143
更新日期:1993-03-01 00:00:00
abstract::Most adenovirus-specific mRNAs expressed late after infection originate from a single transcription unit, the so-called major late transcription unit. All mRNAs expressed from this unit have in common a 201 nucleotide-long spliced tripartite leader segment attached to their 5' ends. Human adenovirus mutants that carry...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1234
更新日期:1993-05-01 00:00:00
abstract::HTLV-I infection is characterized by low viremia and restricted viral expression. While the mechanisms regulating viral latency are poorly understood, it is believed that interactions between viral and host cellular factor(s) are involved. Several lines of evidence indicate that HTLV-I provirus may be methylated in pr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90649-v
更新日期:1991-05-01 00:00:00
abstract::The nucleoprotein (NP) of the influenza A virus encapsidates the viral RNA and participates in the infectious life cycle of the virus. The aims of this study were to find the degree of conservation of NP among all virus subtypes and hosts and to identify conserved binding sites, which may be utilised as potential drug...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.023
更新日期:2014-04-01 00:00:00