Abstract:
:Nanogram amounts of the proinflammatory cytokine interleukin-1alpha (IL-1alpha) were detected in uninfected cultures of human corneal epithelial cells (HCEC). Although HSV-1 replicated >10(4)-fold in these cells and caused extensive cytopathic effects, virus infection was not accompanied by significant extracellular release of IL-1alpha. Additional studies showed that release of radiolabeled cytosolic proteins from virus-infected HCEC was no greater than that released by mock-infected cells. These findings indicate that HSV-1 infection of HCEC does not result in IL-1alpha release because newly formed virus progeny can escape infected cells without disrupting cell membranes.
journal_name
Virologyjournal_title
Virologyauthors
Tran MT,Dean DA,Lausch RN,Oakes JEdoi
10.1006/viro.1998.9084subject
Has Abstractpub_date
1998-04-25 00:00:00pages
74-8issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(98)99084-5journal_volume
244pub_type
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