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Ross River virus variants selected during passage in chick embryo fibroblasts: serological, genetic, and biological changes.

Abstract：

:Serial passage of Ross River virus in chick embryo fibroblasts selected for virus variants altered in their reactions to neutralizing monoclonal antibodies. The E1 and E2 genes of each antigenic variant were sequenced; single nucleotide changes were found in E2 leading to amino acid substitutions at either residue 4 (Glu-->Lys) or 218 (Asn-->Lys); no changes were found in the E1 gene. Variants with the substitution at E2 residue 218 replicated less efficiently in 1-day-old mice than did the parental strain. The variant changed at E2 residue 4 showed little alteration in replication efficiency in mice. Similar genotypic or phenotypic changes were not found in virus passaged serially in human or mosquito cell lines.

journal_name

Virology

journal_title

Virology

authors

Kerr PJ,Weir RC,Dalgarno L

doi

10.1006/viro.1993.1143

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

446-9

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(83)71143-8

journal_volume

193

pub_type

杂志文章

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