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The complete DNA sequence and the genetic organization of the short unique region (US) of the bovine herpesvirus type 1 (ST strain).

Abstract：

:The DNA sequence of bovine herpesvirus type 1 (BHV-1) ST strain (BHV-1.2 subtype) entire unique short (US) region and part of adjacent flanking sequences of the inverted repeats was determined. The BHV-1 ST US region is 9745 bp in size and has a 70.5% G + C content. Eight potential open reading frames (ORFs) longer than 100 amino acids and designated ORF1 to ORF8 were identified on this sequence. Seven of these had counterparts in the US of herpes simplex type 1 (HSV-1), pseudorabies virus (PRV), and equine herpesvirus type 1 (EHV-1). BHV-1 ORF2 encodes a protein homologous to HSV-1 US2; ORF3 putative protein exhibits homology with HSV-1 US3 (serine-threonine protein kinase); ORF4 encodes a putative glycoprotein homologous to PRV gG (gX) and EHV-1 gG (gX); ORFs 5,6, and 7 encode respectively HSV-1 glycoproteins gD, gl, and gE homologues; and ORF8 codes for a putative homologue of HSV-1 US9. Although BHV-1 ST strain apparently lacks a HSV-1 US1 homologue, the genetic content and the genomic organization of its US region was found to be similar to the general organization already described for HSV-1, EHV-1, PRV, and avian herpesviruses HVT and MDV US regions. In fact, the BHV-1 US region genomic organization is the closest to the general consensus determined from the comparison of known alphaherpesvirus US regions.

journal_name

Virology

journal_title

Virology

authors

Leung-Tack P,Audonnet JC,Riviere M

doi

10.1006/viro.1994.1139

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

409-21

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(84)71139-1

journal_volume

199

pub_type

杂志文章

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