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Characterization of human adenovirus serotypes 5, 6, 11, and 35 as anticancer agents.

Abstract：

:Human adenovirus type 5 (Ad5) has been the most popular platform for the development of oncolytic Ads. Alternative Ad serotypes with low seroprevalence might allow for improved anticancer efficacy in Ad5-immune patients. We studied the safety and efficacy of rare serotypes Ad6, Ad11 and Ad35. In vitro cytotoxicity of the Ads correlated with expression of CAR and CD46 in most but not all cell lines. Among CAR-binding viruses, Ad5 was often more active than Ad6, among CD46-binding viruses Ad35 was generally more cytotoxic than Ad11 in cell culture studies. Ad5, Ad6, and Ad11 demonstrated similar anticancer activity in vivo, whereas Ad35 was not efficacious. Hepatotoxicity developed only in Ad5-injected mice. Predosing with Ad11 and Ad35 did not increase infection of hepatocytes with Ad5-based vector demonstrating different interaction of these Ads with Kupffer cells. Data obtained in this study suggest developing Ad6 and Ad11 as alternative Ads for anticancer treatment.

journal_name

Virology

journal_title

Virology

authors

Shashkova EV,May SM,Barry MA

doi

10.1016/j.virol.2009.08.038

subject

Has Abstract

pub_date

2009-11-25 00:00:00

pages

311-20

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(09)00529-7

journal_volume

394

pub_type

杂志文章

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