Abstract:
:Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular mechanisms are unknown. To elucidate the roles that efferocytosis of HIV-1-infected cells play in clearance of infected cells, we sought to identify molecules that mediate these processes. We found that protein S, present in human serum, and its homologue, Gas6, can mediate phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer, expressed on macrophages, to phosphatidylserine exposed on infected cells. Efferocytosis of live infected cells was less efficient than dead infected cells; however, a significant fraction of live infected cells were phagocytosed over 12h. Our results suggest that efferocytosis not only removes dead cells, but may also contribute to macrophage removal of live virus producing cells.
journal_name
Virologyjournal_title
Virologyauthors
Chua BA,Ngo JA,Situ K,Ramirez CM,Nakano H,Morizono Kdoi
10.1016/j.virol.2017.12.025subject
Has Abstractpub_date
2018-02-01 00:00:00pages
176-190eissn
0042-6822issn
1096-0341pii
S0042-6822(17)30438-5journal_volume
515pub_type
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