Abstract:
:The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections as an adjuvant therapy. The major transcription factor which regulates oxygen tension level is hypoxia-inducible factor-1 alpha (HIF-1α). Down-regulating the expression of HIF-1α is a possible method in the treatment of chronic viral infection such as human immunodeficiency virus infection, chronic hepatitis B and C viral infections and Kaposi sarcoma in addition to classic chemotherapy. The aim of this review is to supply an updating concerning the influence of oxygen tension level in human viral infections and to evoke possible new therapeutic strategies regarding this environmental condition.
journal_name
Virologyjournal_title
Virologyauthors
Morinet F,Casetti L,François JH,Capron C,Pillet Sdoi
10.1016/j.virol.2013.06.018subject
Has Abstractpub_date
2013-09-01 00:00:00pages
31-6issue
1-2eissn
0042-6822issn
1096-0341pii
S0042-6822(13)00367-Xjournal_volume
444pub_type
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