Abstract:
:In 2006, an exotic reassortant orbivirus, epizootic hemorrhagic disease virus serotype 6 (EHDV-6) [strain (Indiana)], was first detected in the United States. To characterize the reassortment configuration of this virus and to conclusively determine the parental virus of each RNA segment, the complete genome of EHDV-6 (Indiana) was sequenced, in addition to the genomes of representative EHDV-6 and EHDV-2 isolates. Based on genomic comparisons to all other EHDV serotypes, we determined that EHDV-6 (Indiana) originated from a reassortment event between the Australian prototype strain of EHDV-6 (CSIRO 753) and the North American topotype of EHDV-2 (Alberta). Additionally, phylogenetic analysis of all EHDV-6 (Indiana) isolates detected in the United States from 2006 to 2010 suggests that the virus may be undergoing continual reassortment with EHDV-2 (Alberta). In 2010, EHDV-6 (CSIRO 753) was detected in Guadeloupe, demonstrating that the parental virus of the reassortment event is circulating in the Caribbean.
journal_name
Virologyjournal_title
Virologyauthors
Allison AB,Holmes EC,Potgieter AC,Wright IM,Sailleau C,Breard E,Ruder MG,Stallknecht DEdoi
10.1016/j.virol.2011.12.004subject
Has Abstractpub_date
2012-03-01 00:00:00pages
67-75issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(11)00562-9journal_volume
424pub_type
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