A new retrovirus produced by tissue culture cell line from mammary tumor of a house musk shrew, Suncus murinus.

abstract：:Guinea-Bissau in West Africa has the highest prevalence of human immunodeficiency virus (HIV)-2 infection in the world, but recently the HIV-1 prevalence increased rapidly with the subsequent appearance of HIV-1 and HIV-2 dual infections. Information about the genetic subtypes of HIV in the region is limited. Therefor...

journal_title：Virology

authors： Andersson S,Norrgren H,Dias F,Biberfeld G,Albert J

更新日期：1999-09-30 00:00:00

abstract：:The reactivates of human sera with uninduced and phorbol ester (TPA)-induced human herpesvirus-8 (HHV-8)-infected BCBL-1 cells were examined by immunofluorescence assay (IFA) and by radioimmunoprecipitation reactions (RIP). The seroprevalence of HHV-8 infections is low in the United States general population and only ...

journal_title：Virology

authors： Chandran B,Smith MS,Koelle DM,Corey L,Horvat R,Goldstein E

更新日期：1998-03-30 00:00:00

abstract：:Human adenovirus type 3 (HAdV-B3) has an apparently stable genome yet remains a major circulating and problematic respiratory pathogen. Comparisons of the prototype genome to genomes from three current field strains, including two isolated from epidemics, and a laboratory strain, yielded small-scale nucleotide variati...

journal_title：Virology

authors： Mahadevan P,Seto J,Tibbetts C,Seto D

更新日期：2010-02-05 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB) promotes virion entry into cells by fusing the virion envelope with the cellular membrane. We recently reported that UB cells (U373 glioblastoma cells constructed to produce HCMV gB constitutively) form multinucleate syncytia that are dependent on the density of gB in t...

journal_title：Virology

authors： Tugizov S,Wang Y,Qadri I,Navarro D,Maidji E,Pereira L

更新日期：1995-06-01 00:00:00

abstract：:Previously our laboratory constructed an HIV-1 which stably maintained a primer binding site (PBS) complementary to tRNA(His) by mutating the region of the provirus within U5 postulated to interact with the anticodon of tRNA(His) (J. Wakefield, S-M Kang, and C. D. Morrow, 1996, J. Virol, 70, 966-975). From the analysi...

journal_title：Virology

authors： Li Y,Zhang Z,Kang SM,Buescher JL,Morrow CD

更新日期：1997-11-24 00:00:00

abstract：:A 140,000-dalton disulfide-linked glycoprotein (gp140) specified by varicella-zoster virus (VZV) in infected cultured cells was identified and precipitated by two murine monoclonal antibodies (VZ-151 and VZ-158). When analyzed under reducing conditions by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gp14...

journal_title：Virology

authors： Grose C,Edwards DP,Weigle KA,Friedrichs WE,McGuire WL

更新日期：1984-01-15 00:00:00

abstract：:A human cytomegalovirus (HCMV)-induced polypeptide of 68,000 Da (p68) with protein kinase activity was identified using a monoclonal antibody (F6b) produced against HCMV-infected cell proteins. p68 was detected by immunoprecipitation from 3 to 120 hr after infection and was induced by several strains of human and not ...

journal_title：Virology

authors： Michelson S,Tardy-Panit M,Bârzu O

更新日期：1984-04-30 00:00:00

abstract：:The nucleotide sequence of the genome of the nucleopolyhedrovirus (NPV) from Mamestra configurata (MacoNPV, isolate 90/2), a group II NPV, was determined and analyzed. The MacoNPV DNA genome consists of 155,060 bp and has an overall G+C content of 41.7%. Computer-assisted analysis predicted 169 open reading frames (OR...

journal_title：Virology

authors： Li Q,Donly C,Li L,Willis LG,Theilmann DA,Erlandson M

更新日期：2002-03-01 00:00:00

abstract：:West Nile virus (WNV) is a flavivirus that swept rapidly across North America in 1999, declined in prevalence, and then resurged in 2012. To date, no vaccine is available to prevent infection in the human population. Herpes simplex virus (HSV) replication-defective vaccine vectors induce a durable immunity characteriz...

journal_title：Virology

authors： Taylor TJ,Diaz F,Colgrove RC,Bernard KA,DeLuca NA,Whelan SPJ,Knipe DM

更新日期：2016-09-01 00:00:00

abstract：:Cauliflower mosaic virus (CaMV) strains CM1841 and W260 produced markedly different symptoms when inoculated onto turnips (Brassica campestris L. 'Just Right'). The CM1841 strain induced a mild degree of stunting of infected plants while strain W260 caused moderate to severe stunting. Although CM1841 was significantly...

journal_title：Virology

authors： Anderson EJ,Qui SG,Schoelz JE

更新日期：1991-04-01 00:00:00

abstract：:The unordered N-termini of parvovirus capsid proteins (Nt) are translocated through a channel at the icosahedral five-fold axis to serve for virus traffick. Heterologous peptides were genetically inserted at the Nt of MVM to study their functional tolerance to manipulations. Insertion of a 5T4-single-chain antibody at...

journal_title：Virology

authors： Sánchez-Martínez C,Grueso E,Carroll M,Rommelaere J,Almendral JM

更新日期：2012-10-10 00:00:00

abstract：:Gene transfer into human hematopoietic stem cells using Ad5 is inefficient due to lack of the primary receptor CAR and the secondary receptors alphavbeta3 integrin and alphavbeta5 integrin, and due to the high seroprevalence of Ad5 antibodies in most adults, resulting in diminished gene transduction. In the present st...

journal_title：Virology

authors： Mei YF,Segerman A,Lindman K,Hörnsten P,Wahlin A,Wadell G

更新日期：2004-10-25 00:00:00

abstract：:Although many workers have investigated the maturation and processing of the flavivirus nonstructural glycoprotein NS1 in infected cells, these studies have provided little insight into a possible function for NS1. In this study we investigated the subcellular localization of NS1 both by immunofluorescence and cryo-im...

journal_title：Virology

authors： Mackenzie JM,Jones MK,Young PR

更新日期：1996-06-01 00:00:00

abstract：:Without a virus culture system, genetic analysis becomes the principal method to classify norovirus (NoV) strains. Currently, classification of NoV strains beneath the species level has been based on sequences from different regions of the viral genome. As a result, the phylogenetic insights of some virus were not app...

journal_title：Virology

authors： Zheng DP,Ando T,Fankhauser RL,Beard RS,Glass RI,Monroe SS

更新日期：2006-03-15 00:00:00

abstract：:In our in vitro model for HPV16-mediated transformation, HPV16-immortalized human keratinocytes (HKc/HPV16) give rise to differentiation resistant, premalignant cells (HKc/DR). HKc/DR, but not HKc/HPV16, are resistant to growth inhibition by transforming growth factor beta (TGF-β), due to a partial loss of TGF-β recep...

journal_title：Virology

authors： Kowli S,Velidandla R,Creek KE,Pirisi L

更新日期：2013-12-01 00:00:00

abstract：:The (guanine-N7)-methyltransferase domain of the vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit D1(498-844) bound to a stimulatory subunit D12. To identify structural elements of the 287-amino-acid D12 subunit that participate in binding and activation of the catalytic subunit, we ...

journal_title：Virology

authors： Saha N,Shuman S

更新日期：2001-08-15 00:00:00

abstract：:Replication of Tomato bushy stunt virus (TBSV) RNA takes place on the cytosolic membrane surface of peroxisomes in plants and in yeast, a model host. To identify the host proteins involved in assisting the peroxisomal localization of the tombusvirus p33 replication protein, we tested if p33 could bind directly to yeas...

journal_title：Virology

authors： Pathak KB,Sasvari Z,Nagy PD

更新日期：2008-09-30 00:00:00

abstract：:Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we describe the...

journal_title：Virology

authors： Mettelman RC,O'Brien A,Whittaker GR,Baker SC

更新日期：2019-11-01 00:00:00

abstract：:The antigenic structure of the VP4 protein of human rotavirus (HRV) strains Wa and ST3 was studied by using a panel of Wa- and ST3-derived VP4-specific neutralizing monoclonal antibodies (NMAbs) and NMAb-resistant variants. The VP4-coding genes from three Wa and three ST3 variants were sequenced. For Wa VP4, one homot...

journal_title：Virology

authors： Padilla-Noriega L,Dunn SJ,López S,Greenberg HB,Arias CF

更新日期：1995-01-10 00:00:00

abstract：:In 2006, an exotic reassortant orbivirus, epizootic hemorrhagic disease virus serotype 6 (EHDV-6) [strain (Indiana)], was first detected in the United States. To characterize the reassortment configuration of this virus and to conclusively determine the parental virus of each RNA segment, the complete genome of EHDV-6...

journal_title：Virology

authors： Allison AB,Holmes EC,Potgieter AC,Wright IM,Sailleau C,Breard E,Ruder MG,Stallknecht DE

更新日期：2012-03-01 00:00:00

abstract：:Brain metastases occur commonly in the setting of a variety of human cancers. At present, such cases are invariably fatal and highlight a need for research on new therapies. We have developed a mouse brain tumor model utilizing the Harding-Passey melanoma cell line injected intracranially into C57Bl/6 mice. Tumors dev...

journal_title：Virology

authors： Randazzo BP,Kesari S,Gesser RM,Alsop D,Ford JC,Brown SM,Maclean A,Fraser NW

更新日期：1995-08-01 00:00:00

abstract：:Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR beta x delta-/-) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of...

journal_title：Virology

authors： Szomolanyi-Tsuda E,Brien JD,Dorgan JE,Garcea RL,Woodland RT,Welsh RM

更新日期：2001-02-15 00:00:00

abstract：:Viruses of the Norovirus genus (Caliciviridae family) are a major cause of human gastroenteritis. In some viruses, recombination is an important evolutionary process and therefore we should try to discover the quantity and characteristics of such events in Noroviruses. In order to identify recombination events, multip...

journal_title：Virology

authors： Etherington GJ,Dicks J,Roberts IN

更新日期：2006-02-05 00:00:00

abstract：:Site-directed mutagenesis was performed to change the wild-type residue (asparagine) to aspartate, histidine, or tyrosine at amino acid 424 of the poliovirus RNA polymerase, 3Dpol. The mutations were introduced into plasmids containing full-length viral cDNA and plasmids which direct the expression of 3Dpol in Escheri...

journal_title：Virology

authors： Burns CC,Richards OC,Ehrenfeld E

更新日期：1992-08-01 00:00:00

abstract：:An Autographa californica nuclear polyhedrosis virus gene encoding an occlusion-derived virus (ODV) envelope protein of 56 kDa was identified and sequenced. Transcription initiates from a conserved baculovirus late motif (ATAAG) with transcripts detected from 16 through 72 hr p.i. The protein is detected in infected c...

journal_title：Virology

authors： Braunagel SC,Elton DM,Ma H,Summers MD

更新日期：1996-03-01 00:00:00

abstract：:A clinical feature of Ross River virus disease (RRVD) is the periodic relapse of symptoms months after the initial onset of disease. The underlying mechanisms responsible for this relapse have not been determined. In a long-term (148 days) in vitro study of persistently infected murine macrophages we established that ...

journal_title：Virology

authors： Way SJ,Lidbury BA,Banyer JL

更新日期：2002-09-30 00:00:00

abstract：:At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for...

journal_title：Virology

authors： Rasmussen L,Mullenax J,Nelson M,Merigan TC

更新日期：1985-08-01 00:00:00

abstract：:The influenza RNA polymerase is known to catalyse three distinct copying activities: (i) transcription of minus-sense virion RNA (vRNA) into mRNA, (ii) transcription of vRNA into full-length complementary RNA (cRNA), and (iii) transcription of cRNA to vRNA. Ever since the discovery of the conserved 13 and 12 long sequ...

journal_title：Virology

authors： Seong BL,Brownlee GG

更新日期：1992-01-01 00:00:00

abstract：:The objective of this study was to identify porcine reproductive and respiratory syndrome virus (PRRSV)-encoded proteins that are responsible for the inhibition of TNF-α expression and the mechanism(s) involved in this phenomenon. Using a TNF-α promoter reporter system, the non-structural protein 1 (Nsp1) was found to...

journal_title：Virology

authors： Subramaniam S,Kwon B,Beura LK,Kuszynski CA,Pattnaik AK,Osorio FA

更新日期：2010-10-25 00:00:00

abstract：:The poxvirus virion contains an inner tubular nucleocapsid structure. The nucleocapsid is apparently labile to conventional electron microscopy fixation procedures and has therefore been largely ignored for decades. Advancements in electron microscopy sample preparation, notably high pressure freezing, better preserve...

journal_title：Virology

authors： McFadden BD,Moussatche N,Kelley K,Kang BH,Condit RC

更新日期：2012-12-05 00:00:00