Abstract:
:Human adenovirus type 3 (HAdV-B3) has an apparently stable genome yet remains a major circulating and problematic respiratory pathogen. Comparisons of the prototype genome to genomes from three current field strains, including two isolated from epidemics, and a laboratory strain, yielded small-scale nucleotide variations across 50 years of time and space (U.S. and China). This is in contrast to the recombination events that have been reported recently for HAdV genomes. Recombinant genomes have been identified in emergent HAdV pathogens and is a pathway for the molecular evolution of types. These two contrasting views of HAdV genome stability have repercussions in the development and use of vaccines for countering HAdV-B3, as well as in the continued effectiveness of vaccines developed against earlier and current circulating types of HAdV.
journal_name
Virologyjournal_title
Virologyauthors
Mahadevan P,Seto J,Tibbetts C,Seto Ddoi
10.1016/j.virol.2009.10.052subject
Has Abstractpub_date
2010-02-05 00:00:00pages
113-8issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(09)00700-4journal_volume
397pub_type
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