Abstract:
:Brain metastases occur commonly in the setting of a variety of human cancers. At present, such cases are invariably fatal and highlight a need for research on new therapies. We have developed a mouse brain tumor model utilizing the Harding-Passey melanoma cell line injected intracranially into C57Bl/6 mice. Tumors develop in 100% of the mice and can be detected by magnetic resonance imaging as early as 5 days post cell injection. Death from tumor progression occurs between 12 and 16 days post cell injection. Stereotactic injection of the neuroattenuated HSV-1 strain 1716 into brain tumors 5 or 10 days postinjection of the melanoma cells results in a statistically significant increase in the time to development of neurological symptoms and in complete tumor regression and the long-term survival of some treated animals. Moreover, viral titration studies and immunohistochemistry suggest that replication of this virus is restricted to tumor cells and does not occur in the surrounding brain tissue. These results suggest that HSV-1 mutant 1716 shows particular promise for use as a therapeutic agent for the treatment of brain tumors.
journal_name
Virologyjournal_title
Virologyauthors
Randazzo BP,Kesari S,Gesser RM,Alsop D,Ford JC,Brown SM,Maclean A,Fraser NWdoi
10.1006/viro.1995.1382subject
Has Abstractpub_date
1995-08-01 00:00:00pages
94-101issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(85)71382-7journal_volume
211pub_type
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