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Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.

Abstract：

:Many tumors, including cervical carcinoma, show dysregulated expression of the microRNA processing machinery, specifically DROSHA and DICER. Some cervical cancers exhibit chromosome 5p amplifications and DROSHA is the most significantly upregulated transcript and is observed in all tumors with 5p gain. DROSHA and DICER mRNA levels, however, are higher in HPV positive cancer lines than in an HPV negative cervical carcinoma line. We show that high-risk HPV E6/E7 expression in HPV negative C33A cervical carcinoma cells and primary human epithelial cell causes increased expression of DROSHA and DICER mRNA and protein. Most importantly, many DROSHA regulated microRNAs are dysregulated in HPV16 E6/E7 expressing cells. These results suggest that increased DROSHA levels contribute to HPV16 E6/E7 dysregulation of cellular microRNA expression.

journal_name

Virology

journal_title

Virology

authors

Harden ME,Munger K

doi

10.1016/j.virol.2017.04.022

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

192-198

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(17)30130-7

journal_volume

507

pub_type

杂志文章

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