Influence of extended mutations of the HIV-1 transframe protein p6 on Nef-dependent viral replication and infectivity in vitro.

abstract：:Sequence determinations of the hemagglutinin-neuraminidase (HN) glycoproteins of a temperature-sensitive mutant of Newcastle disease virus and two sequentially selected revertants had previously shown that substitution at a pair of residues, 129 and 175, resulted in a deficiency in neuraminidase (NA) activity, which w...

journal_title：Virology

authors： Sheehan JP,Iorio RM

更新日期：1992-08-01 00:00:00

abstract：:The poxvirus virion contains an inner tubular nucleocapsid structure. The nucleocapsid is apparently labile to conventional electron microscopy fixation procedures and has therefore been largely ignored for decades. Advancements in electron microscopy sample preparation, notably high pressure freezing, better preserve...

journal_title：Virology

authors： McFadden BD,Moussatche N,Kelley K,Kang BH,Condit RC

更新日期：2012-12-05 00:00:00

abstract：:The recent development of in vitro hepatitis C virus (HCV) RNA replication systems has provided useful tools for studying the intracellular anti-HCV activity of ribavirin. Ribavirin has been shown to: (1) induce "error catastrophe" in poliovirus, Proc. Natl. Acad. Sci. USA 98, 6895-6900), (2) be a pseudo-substrate of ...

journal_title：Virology

authors： Zhou S,Liu R,Baroudy BM,Malcolm BA,Reyes GR

更新日期：2003-06-05 00:00:00

abstract：:The long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) encodes a protein which functions as a superantigen. The BALB/cV strain differs from other exogenous MMTVs antigenically, biochemically, on the basis of restriction fragment analysis, and by the specificity of its superantigen for V beta 2+ T cells. In...

journal_title：Virology

authors： Kang JJ,Schwegel T,Knepper JE

更新日期：1993-09-01 00:00:00

abstract：:Demyelination of the human peripheral nervous system (PNS) can be caused by diverse mechanisms including viral infection. Despite association of several viruses with the development of peripheral demyelination, animal models of the condition have been limited to disease that is either autoimmune or genetic in origin. ...

journal_title：Virology

authors： Drescher KM,Tracy SM

更新日期：2007-03-01 00:00:00

abstract：:In this study, we present enzymatic differences found between recombinant RTs derived from feline leukemia virus and feline immunodeficiency virus. Firstly, FIV RT showed low steady state K(m) values for dNTPs compared to FeLV RT. Consistent with this, FIV RT synthesized DNA more efficiently than FeLV RT at low dNTP c...

journal_title：Virology

authors： Operario DJ,Reynolds HM,Kim B

更新日期：2005-04-25 00:00:00

abstract：:Many viruses activate the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, thereby modulating diverse downstream signaling pathways associated with antiapoptosis, proliferation, cell cycling, protein synthesis and glucose metabolism, in order to augment their replication. To date, the role of the PI3K-Akt p...

journal_title：Virology

authors： Xiao W,Yang Y,Weng Q,Lin T,Yuan M,Yang K,Pang Y

更新日期：2009-08-15 00:00:00

abstract：:CD8(+) T-lymphocytes from HIV-1 infected individuals express unidentified factors that suppress viral replication by inhibiting HIV-1 gene expression. We examined the role of epigenetics in modulating the HIV-1 suppressive factors expressed by primary CD8(+) T cells from subjects naturally controlling virus replicatio...

journal_title：Virology

authors： Saunders KO,Freel SA,Overman RG,Cunningham CK,Tomaras GD

更新日期：2010-09-15 00:00:00

abstract：:The gene encoding the VP8* trypsin-cleavage product of the VP4 protein of porcine rotavirus strain A34 was sequenced, and the predicted amino acid (aa) sequence was compared to the homologous region of all known P genotypes. The aa sequence of the VP8* of strain A34 shared low identity, ranging from 39% (bovine strain...

journal_title：Virology

authors： Liprandi F,Gerder M,Bastidas Z,López JA,Pujol FH,Ludert JE,Joelsson DB,Ciarlet M

更新日期：2003-10-25 00:00:00

abstract：:Granulin and polyhedrin proteins were purified by preparative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis from the baculoviruses Autographa californica, Rachiplusia ou, Heliothis zea, Heliothis armigera, Trichoplusia ni, and Spodoptera frugiperda. Antisera were raised against Autographa californica...

journal_title：Virology

authors： Summers MD,Hoops P

更新日期：1980-05-01 00:00:00

abstract：:Human papillomavirus (HPV) DNA is preferentially found in spontaneous abortions, specifically residing in trophoblasts, and transfected HPV-16 DNA replicates and produces progeny in 3A trophoblasts in culture. In this study 3A trophoblasts were shown to display both HPV receptors and infection by HPV-31b and HPV-6 vir...

journal_title：Virology

authors： You H,Liu Y,Agrawal N,Prasad CK,Chiriva-Internati M,Lowery CL,Kay HH,Hermonat PL

更新日期：2003-11-25 00:00:00

abstract：:Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...

journal_title：Virology

authors： Campoy S,Hervàs A,Busquets N,Erill I,Teixidó L,Barbé J

更新日期：2006-08-01 00:00:00

abstract：:The open reading frame EP153R, located within the EcoRI E' fragment of the African swine fever (ASF) virus genome, is predicted to encode a membrane protein of 153 amino acids that presents significant homology to the N-terminal region of several CD44 molecules. EP153R contains multiple putative sites for N-glycosylat...

journal_title：Virology

authors： Galindo I,Almazán F,Bustos MJ,Viñuela E,Carrascosa AL

更新日期：2000-01-20 00:00:00

abstract：:Arabis mosaic virus is a subgroup A nepovirus. The RNA1-encoded polyprotein (P1) contains the domains for the NTP-binding protein (NTB), VPg, proteinase (Pro) and polymerase at its C-terminus. Putative cleavage sites delineating these domains have been proposed. However, the number and location of cleavage sites upstr...

journal_title：Virology

authors： Wetzel T,Chisholm J,Bassler A,Sanfaçon H

更新日期：2008-05-25 00:00:00

abstract：:Lentiviral vectors have gained much attention in recent years mainly because they integrate into nondividing host-cell genomes. For clinical applications, a safe and efficient lentiviral vector system is required. Previously, we have established a human immunodeficiency virus type 1 (HIV-1)-derived three-plasmid lenti...

journal_title：Virology

authors： Iwakuma T,Cui Y,Chang LJ

更新日期：1999-08-15 00:00:00

abstract：:Phylogenetic analysis of the N8 neuraminidase (NA) genes from 18 influenza A viruses, representing equine and avian hosts in different geographic locations, revealed three major lineages: (i) currently circulating equine 2 viruses; (ii) avian viruses isolated in the Eurasian region, including A/Equine/Jilin/1/89, a re...

journal_title：Virology

authors： Saito T,Kawaoka Y,Webster RG

更新日期：1993-04-01 00:00:00

abstract：:Spindle-shaped viruses are a dominant morphotype in hypersaline waters but their molecular characteristics and their relationship to other archaeal viruses have not been determined. Here, we describe the isolation, characteristics and genome sequence of His2, a spindle-shaped halovirus, and compare it to the previousl...

journal_title：Virology

authors： Bath C,Cukalac T,Porter K,Dyall-Smith ML

更新日期：2006-06-20 00:00:00

abstract：:To gain new insights regarding the role of Ku, the DNA-PK DNA-binding component, during lentiviral DNA integration, we have investigated the HIV-1 replication in Ku80-depleted human cells. CEM4fx cells underexpressing the Ku80 factor were selected after transduction by a retroviral vector expressing the Ku80 full-leng...

journal_title：Virology

authors： Jeanson L,Subra F,Vaganay S,Hervy M,Marangoni E,Bourhis J,Mouscadet JF

更新日期：2002-08-15 00:00:00

abstract：:The nucleotide sequence of two variants of coconut tinangaja viroid (CTiV) were obtained. Both sequence variants are 254 nucleotide residues in size but differ in sequence at two positions. In comparisons with other viroids, the sequences and proposed secondary structure of CTiV show most homology with the 246 nucleot...

journal_title：Virology

authors： Keese P,Osorio-Keese ME,Symons RH

更新日期：1988-02-01 00:00:00

abstract：:The morbilliviruses are a closely related genus which are very similar in their sequences and share a common receptor, but nevertheless show significant restriction in the host species in which they cause disease. One contribution to this restriction might be the nature of the hosts' responses to infection. We have us...

journal_title：Virology

authors： Nanda SK,Baron J,Royall E,Robinson L,Falciani F,Baron MD

更新日期：2009-12-20 00:00:00

abstract：:The interaction between the viral envelope protein gp120 and the cellular surface antigen CD4 is a key event in HIV-1 infection. Reciprocal high affinity binding sites have been located in the first domain of CD4 and in the carboxy-terminal region of gp120, respectively. Upon infection, the membranes of the target cel...

journal_title：Virology

authors： Autiero M,Abrescia P,Dettin M,Di Bello C,Guardiola J

更新日期：1991-12-01 00:00:00

abstract：:We have previously shown that the Edmonston strain of measles virus enters and is released preferentially at the apical surfaces of polarized epithelial cells. Small amounts of virus were found to be released at the basal surface. In the present study, we passaged the virus in polarized cells and characterized the pas...

journal_title：Virology

authors： Blau DM,Compans RW

更新日期：1997-05-12 00:00:00

abstract：:Parotid tumor agent was an early name for polyomavirus due to its ability to induce tumors (myoepitheliomas originating from the myoepithelial glandular tissues) in mice inoculated with polyomavirus (Py) as neonates. It has long been thought that these tumors directly follow productive infection by Py in epithelial ce...

journal_title：Virology

authors： Atencio IA,Meraz A,Villarreal LP

更新日期：1994-05-01 00:00:00

abstract：:Synthesis of unintegrated retroviral DNA via reverse transcription is thought to involve two separate template switches. Minus-strand strong-stop DNA, a major product of in vitro reactions using detergent-treated virions, is synthesized prior to the first template switch. Plus-strand strong-stop DNA, which is found ba...

journal_title：Virology

authors： Li P,Stephenson AJ,Kuiper LJ,Burrell CJ

更新日期：1993-05-01 00:00:00

abstract：:NF-kappaB comprises a family of transcription factors that regulate key immune processes. In this study, the effects of orthopoxvirus infection upon the activation of NF-kappaB were examined. During the early phase of infection, cowpox virus can inhibit the induction of NF-kappaB-regulated gene expression by interferi...

journal_title：Virology

authors： Oie KL,Pickup DJ

更新日期：2001-09-15 00:00:00

abstract：:The mechanism and machinery of hepatitis C virus (HCV) RNA replication are still poorly characterized. Our previous study has shown that HCV RNA synthesis occurs on a lipid raft membrane structure [J. Virol. 77 (2003) 77 4160]. In this study, we further characterized these replication complexes (RCs) in Huh-7 cells th...

journal_title：Virology

authors： Aizaki H,Lee KJ,Sung VM,Ishiko H,Lai MM

更新日期：2004-07-01 00:00:00

abstract：:The genes of the RF strain of bovine rotavirus have been cloned into pBR 322 following the synthesis and hybridization of cDNA transcribed from both strands of in vitro polyadenylated genomic RNA. Cloned rotavirus DNAs were assigned to most of the 11 genomic RNA segments by Northern blot hybridization. The complete se...

journal_title：Virology

authors： Cohen J,Lefevre F,Estes MK,Bremont M

更新日期：1984-10-15 00:00:00

abstract：:Zika virus (ZIKV) nonstructural protein 5 (NS5) is a multifunctional protein possessing methyltransferase and RNA-dependent RNA polymerase activities. In the present study, we have carried out an extensive mutagenesis analysis to determine the importance of nuclear localization sequences (NLS) of NS5 in its nuclear ac...

journal_title：Virology

authors： Ji W,Luo G

更新日期：2020-02-01 00:00:00

abstract：:Multibranched peptides (SPCs) derived either from the fusion protein (gp41) sequence or from the cleavage sequence of the human immunodeficiency virus type 1 envelope were chemically synthesized and tested for their ability to inhibit both syncytium formation and HIV production in CD4+ cells. The gp41-derived SPCs had...

journal_title：Virology

authors： Sabatier JM,Mabrouk K,Moulard M,Rochat H,Van Rietschoten J,Fenouillet E

更新日期：1996-09-15 00:00:00

abstract：:It has recently been shown that RNA from the bottom component of cowpea mosaic virus is capable of self-replication in cowpea mesophyll protoplasts, providing a tool for the investigation of the contribution of each RNA strand toward viral multiplication. Evidence is presented here, using this system, to show that the...

journal_title：Virology

authors： Stanley J,Goldbach R,Van Kammen A

更新日期：1980-10-15 00:00:00