Abstract:
:Human CD4 was expressed on a range of mammalian cell lines. CD4+ non-primate cells, derived from rat, hamster, mink, cat, and rabbit, bind recombinant gp120 of human immunodeficiency virus type 1 (HIV-1) but are resistant to HIV-1 infection. CD4 expression on various human, rhesus, and African green monkey cell lines confers differential susceptibilities for HIV-1, HIV-2, and simian immunodeficiency (SIV) strains. For example, CD4+ TE671 rhabdomyosarcoma cells are sensitive to HIV-1 and HIV-2 but resistant to SIV, whereas CD4+ U87 glioma cells are resistant to HIV-1 infection but sensitive to HIV-2 and SIV. HIV-1 infection was not dependent on human major histocompatibility class I expression. Studies of cell fusion and of infection by vesicular stomatitis virus pseudotypes bearing HIV-1 and HIV-2 envelopes showed that the differential cell tropisms of HIV-1, HIV-2, and SIV are determined at the cell surface.
journal_name
Virologyjournal_title
Virologyauthors
Clapham PR,Blanc D,Weiss RAdoi
10.1016/0042-6822(91)90904-psubject
Has Abstractpub_date
1991-04-01 00:00:00pages
703-15issue
2eissn
0042-6822issn
1096-0341journal_volume
181pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Genetic variants surrounding the interferon-λ3 (IFNL3) gene are strongly associated with clearance of hepatitis C virus (HCV). A variant (rs368234815 TT/ΔG) upstream of IFNL3 was recently implicated to control expression of a novel gene termed IFNL4. We conducted genetic analysis of rs368234815 in a chronic HCV patien...
journal_title:Virology
pub_type: 临床试验,杂志文章
doi:10.1016/j.virol.2014.12.020
更新日期:2015-02-01 00:00:00
abstract::Viroids are small, nontranslatable pathogenic RNAs that replicate autonomously and traffic systemically in their host plants. We have used in situ hybridization to analyze the trafficking pattern of Potato spindle tuber viroid (PSTVd) in tomato and Nicotiana benthamiana. When PSTVd was inoculated onto the stem of a pl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0724
更新日期:2001-01-05 00:00:00
abstract::Monoclonal antibody 1B4, previously shown to be protective in vivo and to cross-react with both virally encoded and normal host cell proteins, was used to screen a lambda gt11 cDNA derived from mRNA harvested from mouse embryo fibroblasts 24 hr after infection with murine cytomegalovirus (MCMV). A 700-bp cDNA was iden...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1227
更新日期:1994-05-01 00:00:00
abstract::In this report, we present the DNA sequence and transcriptional characterization of a gene (IR5) that maps within each of the inverted repeat (IR) segments of the equine herpesvirus type 1 (EHV-1) genome. The IR5 open reading frame (ORF) is located within both IR sequences (nucleotides 9932-10,642 of the IR). DNA sequ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90525-t
更新日期:1992-06-01 00:00:00
abstract::A collection of randomly generated temperature-sensitive (ts) vaccinia virus (strain IHD-W) mutants were reported by S. Dales et al., (1978, Virology, 84, 403-428) in 1978 and characterized by electron microscopy. We have performed further genetic analysis on the Dales collection of mutants to make the mutants more us...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1745
更新日期:2003-01-20 00:00:00
abstract::Nectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superfamily, and a cellular adhesion molecule. To study domains of nectin-1alpha involved in cell fusion, we measured the ability of nectin-1alpha/nectin-2alpha chimeras, nectin-1alpha/CD4 chimeras, and transmembrane domain and cytop...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.05.031
更新日期:2005-09-01 00:00:00
abstract::The Pr76Gag and Pr180Gag-Pol polyprotein precursors of Rous sarcoma virus contain a 22-amino-acid spacer peptide, called p2, located between the amino acid sequences of the mature Gag proteins MA and p10. This spacer peptide is present in stoichiometric amounts in the virion, albeit cleaved into two parts, but its fun...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1450
更新日期:1994-08-15 00:00:00
abstract::We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV resistance, compared to either single mutant. Unexpectedly, K101E+G190S also repli...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.03.018
更新日期:2010-07-05 00:00:00
abstract::The Nef protein of Simian immunodeficiency virus (SIV) associates with multiple T lymphocyte signaling proteins, including the T cell receptor (TCR) zeta chain. We demonstrate here that these interactions are conserved and highly specific. Nefs derived from genetically diverse strains of SIV (SIV(mac)239, SIV(smm)PBj,...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1628
更新日期:2002-10-10 00:00:00
abstract::The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.10.011
更新日期:2013-02-05 00:00:00
abstract::Within the family of Poxviridae, the entomopoxviruses are the most distant relatives of the more well-known and intensively studied orthopoxviruses (vaccinia and variola). The growth of the entomopoxvirus from Amsacta moorei (AmEPV) has been characterized in cell culture and compared to that of vaccinia virus (VV), th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1428
更新日期:1995-08-20 00:00:00
abstract::The protein p10 that forms the connector of phage phi 29, has been produced in Escherichia coli harboring a plasmid that carried the gene coding for this protein. The connector protein is assembled in a 13.4-S oligomer that has an apparent molecular weight of 460,000, suggesting that it is a dodecamer. The purified ol...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90251-x
更新日期:1985-03-01 00:00:00
abstract::We used serial protein misfolding cyclic amplification (sPMCA) to amplify the D10 strain of CWD prions in a linear relationship over two logs of D10 dilutions. The resultant PMCA-amplified D10 induced terminal TSE disease in CWD-susceptible Tg(cerPrP)1536 mice with a survival time approximately 80 days shorter than th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.09.023
更新日期:2008-12-20 00:00:00
abstract::Two small viral proteins (DGBp1 and DGBp2) have been proposed to act in a concerted manner to aid intra- and intercellular trafficking of carmoviruses though the distribution of functions and mode of action of each protein partner are not yet clear. Here we have confirmed the requirement of the DGBps of Pelargonium fl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.001
更新日期:2011-05-10 00:00:00
abstract::Interferon gamma (IFNγ) has complex immunomodulatory and antiviral properties. While IFNγ is detected in the airways in response to infection with the pneumovirus pathogen, pneumonia virus of mice (PVM; Family Paramyxoviridae), its role in promoting disease has not been fully explored. Here, we evaluate PVM infection ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.07.039
更新日期:2014-11-01 00:00:00
abstract::We previously demonstrated that cellular mRNAs are degraded in CD4 positive lymphocytes infected by the human immunodeficiency virus, HIV-1, but not in cells infected by the simian lentivirus, SIV. To begin to define the molecular mechanisms underlying this RNA degradation, we have established an in vitro RNA degradat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0103
更新日期:1996-03-01 00:00:00
abstract::The allele Pp of gene ref(2)P of Drosophila melanogaster is known to inhibit the multiplication of certain strains of Sigma virus. From a viral strain for which the allele PP of ref(2)P is nonpermissive, host adapted (haP) mutants were selected after mutagenesis in vivo. Mutagenized virus was extracted from infected f...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(81)90227-0
更新日期:1981-10-31 00:00:00
abstract::We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.05.039
更新日期:2013-09-01 00:00:00
abstract::Murine gammaherpesvirus 68 (MHV-68) replicates robustly in cell culture, providing a model for studying viral genome replication during de novo infection of tumor-associated herpesviruses. We have previously identified a 1.25-kb origin of lytic replication (oriLyt) for MHV-68. To further investigate the molecular mech...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.02.029
更新日期:2009-05-10 00:00:00
abstract::The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the resp...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.002
更新日期:2014-03-01 00:00:00
abstract::Tetherin (ST2/CD317) is a cellular protein that restricts the release from cells of some enveloped viruses including HIV-1. To examine if influenza virus is affected by tetherin, MDCK cells constitutively expressing human tetherin and control MDCK cells were infected with influenza virus. No difference was observed in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.05.006
更新日期:2011-08-15 00:00:00
abstract::Rice dwarf virus (RDV) spreads, along actin-based filopodia, as one of the ways of its transport, from infected to non-infected cells of its vector insect via tubules that are composed of the viral nonstructural protein Pns10 and contain viral particles. An inhibitor that perturbs the endomembrane system, namely, bref...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.10.034
更新日期:2008-03-15 00:00:00
abstract::Viruses in certain genera in family Caulimoviridae were shown to integrate their genomic sequences into their host genomes and exist as endogenous pararetroviral sequences (EPRV). However, members of the genus Caulimovirus remained to be the exception and are known to exist only as episomal elements in the infected ce...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.03.003
更新日期:2008-07-05 00:00:00
abstract::Viral vectors were constructed from infectious cDNA clones of each of the three tobraviruses, tobacco rattle virus (TRV), pea early-browning virus (PEBV), and pepper ringspot virus (PepRSV). RNA2 of each of the three viruses was modified to carry an additional coat protein subgenomic promoter and was used to express g...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0098
更新日期:2000-02-01 00:00:00
abstract::The SARS-coronavirus (SARS-CoV) is the etiological agent of severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. To delineate functional domains of the SARS-CoV S glycoprotein, single point mutations, clu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.06.046
更新日期:2005-10-25 00:00:00
abstract::During Herpes simplex virus envelopment, capsids, tegument polypeptides, and membrane proteins assemble at the site of budding and a cellular lipid bilayer becomes refashioned into a spherical envelope. Though the molecular interactions driving these events are poorly understood, several lines of evidence suggest that...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.08.023
更新日期:2003-12-05 00:00:00
abstract::The HCMV IE2 protein promiscuously activates transcription of many viral and cellular genes. IE2 also negatively autoregulates its own expression by binding to a strategically positioned IE2 binding site, called CRS, located immediately downstream of the TATA box of the HCMV major IE promoter. Here we show that IE2 is...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8855
更新日期:1997-11-24 00:00:00
abstract::High Plains wheat mosaic virus (HPWMoV, genus Emaravirus; family Fimoviridae), transmitted by the wheat curl mite (Aceria tosichella Keifer), harbors a monocistronic octapartite single-stranded negative-sense RNA genome. In this study, putative proteins encoded by HPWMoV genomic RNAs 2-8 were screened for potential RN...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.02.013
更新日期:2018-05-01 00:00:00
abstract::The 20,349-bp sequence of the human cytomegalovirus (HCMV) HindIII F fragment has revealed eight open reading frames with homology to herpes simplex virus (HSV) and/or Epstein-Barr virus (EBV). With respect to EBV, these homologous genes can be divided into two blocks: one block contains three genes, including the DNA...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90282-0
更新日期:1987-04-01 00:00:00
abstract::We have cloned an infectious genome of the Junonia coenia densonucleosis virus (JcDNV) into the bacterial plasmid pBR322. The viral genome could be rescued from the recombinant plasmid pBRJ by transfection of pBRJ DNA to sensitive Spodoptera littoralis larvae. pBRJ DNA produced a typical viral infection and a comparab...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90308-e
更新日期:1990-11-01 00:00:00