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Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas.

Abstract：

:The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these "virulent" genotypes.

journal_name

Virology

journal_title

Virology

authors

Rico-Hesse R,Harrison LM,Salas RA,Tovar D,Nisalak A,Ramos C,Boshell J,de Mesa MT,Nogueira RM,da Rosa AT

doi

10.1006/viro.1997.8504

subject

Has Abstract

pub_date

1997-04-14 00:00:00

pages

244-51

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042682297985044

journal_volume

230

pub_type

杂志文章

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