Analysis of Hantaan virus RNA: evidence for a new genus of bunyaviridae.

abstract：:We used serial protein misfolding cyclic amplification (sPMCA) to amplify the D10 strain of CWD prions in a linear relationship over two logs of D10 dilutions. The resultant PMCA-amplified D10 induced terminal TSE disease in CWD-susceptible Tg(cerPrP)1536 mice with a survival time approximately 80 days shorter than th...

journal_title：Virology

authors： Meyerett C,Michel B,Pulford B,Spraker TR,Nichols TA,Johnson T,Kurt T,Hoover EA,Telling GC,Zabel MD

更新日期：2008-12-20 00:00:00

abstract：:The prevalence of hepatitis B virus vaccine escape mutants has increased as a consequence of the introduction of global vaccination programs. Furthermore and as a consequence of the organization of the genome of hepatitis B virus (HBV) into overlapping reading frames, the selection of polymerase mutants during long-te...

journal_title：Virology

authors： Torresi J,Earnest-Silveira L,Deliyannis G,Edgtton K,Zhuang H,Locarnini SA,Fyfe J,Sozzi T,Jackson DC

更新日期：2002-02-15 00:00:00

abstract：:The papillomavirus (PV) E2 protein activates transcription and replication by recruiting cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We recently demonstrated that phosphorylation of tyrosine 102 in the bovine papillomavirus (BPV-1) E2 protein restricts these activities and tha...

journal_title：Virology

authors： DeSmet M,Kanginakudru S,Jose L,Xie F,Gilson T,Androphy EJ

更新日期：2018-08-01 00:00:00

abstract：:Two forms of JC virus (JCV) have been isolated from its human host, an archetype found in kidney tissue and urine of nonimmunocompromised individuals and a rearranged type detected in lymphocytes and brain tissue of patients with and without progressive multifocal leukoencephalopathy. To investigate the hypothesis tha...

journal_title：Virology

authors： Daniel AM,Swenson JJ,Mayreddy RP,Khalili K,Frisque RJ

更新日期：1996-02-01 00:00:00

abstract：:Ten human genital invasive squamous cell carcinomas and five human premalignant tissues were analyzed for the presence of selected sets of herpes simplex virus 2 (HSV-2) DNA sequences. Two vulvar tumors and one vulvar dysplastic tissue were found to contain DNA sequences homologous to the BglII O fragment (coordinates...

journal_title：Virology

authors： Manservigi R,Cassai E,Deiss LP,Di Luca D,Segala V,Frenkel N

更新日期：1986-11-01 00:00:00

abstract：:Two sets of primers derived from the 5'-terminal region and the NS5 region of the hepatitis G virus (HGV) genome were used to amplify PCR fragments from serum specimens obtained from different parts of the world. All PCR fragments from the 5'-terminal region (5'-PCR, n = 56) and from the NS5 region (NS5-PCR, n = 85) w...

journal_title：Virology

authors： Cong M,Fried MW,Lambert S,Lopareva EN,Zhan M,Pujol FH,Thyagarajan SP,Byun KS,Fields HA,Khudyakov YE

更新日期：1999-03-15 00:00:00

abstract：:The SV40 large T-antigen (TAg) has proven useful in studying pathways involved with cell division and tissue homeostasis. TAg disrupts the normal action of tumor suppressors pRb and p53. It is unclear whether T-antigen inhibition of p53 and pRb is sufficient for oncogenic transformation or if additional T-antigen acti...

journal_title：Virology

authors： Sachsenmeier KF,Pipas JM

更新日期：2001-04-25 00:00:00

abstract：:Antigenic sites on the G1 glycoprotein of La Crosse bunyavirus were defined by constructing a panel of neutralizing and nonneutralizing monoclonal antibodies (F. Gonzalez-Scarano, R. E. Shope, C. H. Calisher, and N. Nathanson (1982), Virology 120, 42-53). To analyze the relationship between the individual epitopes del...

journal_title：Virology

authors： Najjar JA,Gentsch JR,Nathanson N,Gonzalez-Scarano F

更新日期：1985-07-30 00:00:00

abstract：:In 2006, an exotic reassortant orbivirus, epizootic hemorrhagic disease virus serotype 6 (EHDV-6) [strain (Indiana)], was first detected in the United States. To characterize the reassortment configuration of this virus and to conclusively determine the parental virus of each RNA segment, the complete genome of EHDV-6...

journal_title：Virology

authors： Allison AB,Holmes EC,Potgieter AC,Wright IM,Sailleau C,Breard E,Ruder MG,Stallknecht DE

更新日期：2012-03-01 00:00:00

abstract：:Human schlafen11 is a novel restriction factor for HIV-1 based on bias regarding relative synonymous codon usage (RSCU). Here, we report the cloning of equine schlafen11 (eSLFN11) and the characteristics of its role in restricting the production of equine infectious anemia virus (EIAV), a retrovirus similar to HIV-1. ...

journal_title：Virology

authors： Lin YZ,Sun LK,Zhu DT,Hu Z,Wang XF,Du C,Wang YH,Wang XJ,Zhou JH

更新日期：2016-08-01 00:00:00

abstract：:The guinea pig cytomegalovirus (GPCMV) co-linear gene and potential functional homolog of HCMV UL84 (GP84) was investigated. The GP84 gene had delayed early transcription kinetics and transient expression studies of GP84 protein (pGP84) demonstrated that it targeted the nucleus and co-localized with the viral DNA poly...

journal_title：Virology

authors： McGregor A,Choi KY,Schleiss MR

更新日期：2011-02-05 00:00:00

abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) vFLIP, a latent gene of KSHV, was first identified as a FLICE-inhibitory protein (FLIP) protecting cells from apoptosis. The vFLIP protein has been shown to activate the NF-κB signaling involved in spindle morphology formation both in HUVECs infected with KSHV and Ka...

journal_title：Virology

authors： Yang Z,Honda T,Ueda K

更新日期：2018-09-01 00:00:00

abstract：:NS35, a basic protein encoded by gene 8 of SA11 rotavirus, possesses RNA-binding activity and is essential for genome replication. To identify conserved regions in the NS35 gene and its protein product, we determined the nucleotide sequences of the NS35 gene for the mammalian and avian rotaviruses Wa, DS1, SA11 (Patto...

journal_title：Virology

authors： Patton JT,Salter-Cid L,Kalbach A,Mansell EA,Kattoura M

更新日期：1993-02-01 00:00:00

abstract：:HK97 is a temperate dsDNA bacteriophage of Escherichia coli that is structurally similar to phage lambda, with an icosahedral head of triangulation (7) number 7. Although the capsids of several large dsDNA phages have been studied extensively using a variety of biophysical approaches, no high-resolution structure is a...

journal_title：Virology

authors： Wikoff WR,Duda RL,Hendrix RW,Johnson JE

更新日期：1998-03-30 00:00:00

abstract：:Human Cytomegalovirus (HCMV) infection is compromised in cells lacking p53, a transcription factor that mediates cellular stress responses. In this study we have investigated compromised functional virion production in cells with p53 knocked out (p53KOs). Infectious center assays found most p53KOs released functional ...

journal_title：Virology

authors： Kuan MI,O'Dowd JM,Chughtai K,Hayman I,Brown CJ,Fortunato EA

更新日期：2016-10-01 00:00:00

abstract：:Mouse hepatitis virus (MHV) JHMV and its soluble receptor-resistant (srr) mutants, srr7, srr11, and srr18, grew and induced syncytia equally well in BHK-R1 cells expressing the MHVR1 receptor derived from MHV-susceptible BALB/c mice. In contrast, srr growth and syncytia formations were drastically reduced relative to ...

journal_title：Virology

authors： Matsuyama S,Taguchi F

更新日期：2000-07-20 00:00:00

abstract：:The temperate Streptococcus thermophilus bacteriophage TP-J34 was identified in the lysogenic host strain J34. The majority of phage particles produced upon induction was defective and noninfectious, consisting of DNA-filled heads lacking tails. A physical map (45.6 kb) was established. Analysis of minor restriction b...

journal_title：Virology

authors： Neve H,Freudenberg W,Diestel-Feddersen F,Ehlert R,Heller KJ

更新日期：2003-10-10 00:00:00

abstract：:The envelope protein of yellow fever virus 17D (YFV-17D) contains a solvent-exposed RGD motif, which has led to the suggestion that integrins may function as cellular receptors for YFV-17D. We found that mutating the RGD motif to RGE had no effect on viral titers, whereas changing RGD to TGD, TGE, TAD, TAE, or RGS led...

journal_title：Virology

authors： van der Most RG,Corver J,Strauss JH

更新日期：1999-12-05 00:00:00

abstract：:The alphaherpesviruses establish latent infections in sensory neuronal cells, during which a number of latency-associated RNA transcripts (LATs) are produced. The reasons for the production of the LATs, however, and the mechanism by which the LAT region of the genome remains active during latency are unknown. Here we ...

journal_title：Virology

authors： Coffin RS,Howard MK,Latchman DS

更新日期：1995-06-01 00:00:00

abstract：:Virulence markers to distinguish high from low virulence bovine viral diarrhea virus genotype 2 isolates have not been previously reported. The objective of this study was to identify virulence markers by evaluating the primary and secondary structures of the 5'-untranslated region of low and high virulence bovine vir...

journal_title：Virology

authors： Topliff CL,Kelling CL

更新日期：1998-10-10 00:00:00

abstract：:While trying to generate a site-directed deletion in the ORF63 latency-associated gene of varicella-zoster virus (VZV) Oka, we constructed a virus with an unexpected rearrangement. The virus has a small deletion in both copies of ORF63 and two copies of a cassette inserted between ORFs 64/65 and 68/69 containing (a) t...

journal_title：Virology

authors： Ambagala AP,Krogmann T,Qin J,Pesnicak L,Cohen JI

更新日期：2010-04-10 00:00:00

abstract：:We have constructed chimeric papillomavirus-like particles (CVLPs) by replacing the 34-carboxy-terminal amino acids of the HPV 16 L1 protein with various parts of the HPV 16 E7 protein. Chimeric proteins were expressed by recombinant baculoviruses and analyzed by electron microscopy for their ability to assemble into ...

journal_title：Virology

authors： Müller M,Zhou J,Reed TD,Rittmüller C,Burger A,Gabelsberger J,Braspenning J,Gissmann L

更新日期：1997-07-21 00:00:00

abstract：:The PstI-N genomic fragment of Autographa californica nuclear polyhedrosis virus (AcNPV) encodes an immediate-early protein, IE2, that functions as a promiscuous transactivator of other early viral promoters and heterologous promoters both in vivo and in vitro. IE2 contains several sequence motifs that are common to t...

journal_title：Virology

authors： Yoo S,Guarino LA

更新日期：1994-07-01 00:00:00

abstract：:We have examined the expression of duck hepatitis B virus (DHBV)-associated proteins in experimentally infected ducks by an immunoblot (Western) method. The DHBV-related core protein, C protein, was identified at the position of 35,000 Da (P35). Pre-S proteins were recognized as two major bands (P37 and P28), the form...

journal_title：Virology

authors： Yokosuka O,Omata M,Ito Y

更新日期：1988-11-01 00:00:00

abstract：:We previously provided evidence for a model of herpes simplex virus type 1 (HSV-1) entry by a cascade of interactions between components of the virion envelope and cellular plasma membrane (Fuller and Lee, 1992, J. Virol. 66, 5002-5012). In this report we have determined entry kinetics of wild-type HSV-1 into two high...

journal_title：Virology

authors： McClain DS,Fuller AO

更新日期：1994-02-01 00:00:00

abstract：:The splice acceptor site of pX gene of HTLV-I has been determined to be at base position 7301 using S1 nuclease protection analysis. This splice acceptor site is used in all HTLV-I immortalized T-cell clones studied despite variation in the abundance levels of pX mRNA. Our results confirmed the proposal by Haseltine e...

journal_title：Virology

authors： Okamoto T,Josephs SF,Kawanishi M,Wong-Staal F

更新日期：1985-06-01 00:00:00

abstract：:The lung-derived dendritic cell (LDC) recruitment following intranasal (i.n.) vaccination of different poxviral vector-based vaccines/adjuvants were evaluated to decipher how these factors influenced CD8(+) T cell avidity. Compared to the standard i.n. recombinant fowlpox virus (FPV)-HIV vaccination, the FPV-HIV IL-13...

journal_title：Virology

authors： Trivedi S,Jackson RJ,Ranasinghe C

更新日期：2014-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) encodes a polyprotein that is processed to produce the structural and nonstructural proteins of the virus. Nonstructural protein 3 (NS3) is a serine proteinase that cleaves the polyprotein to release the NS4A, NS4B, NS5A, and NS5B proteins. To characterize the substrate specificity of NS3, we s...

journal_title：Virology

authors： Leinbach SS,Bhat RA,Xia SM,Hum WT,Stauffer B,Davis AR,Hung PP,Mizutani S

更新日期：1994-10-01 00:00:00

abstract：:It has been demonstrated in a number of systems that CD8+ T cells (T CD8+) can be induced by peptides encoded in alternative reading frames (ARFs) that do not appear to code for bona fide proteins. The biological relevance of ARF peptides remains to be firmly established, however. With this as a goal, we systematicall...

journal_title：Virology

authors： Chen W,Bennink JR,Yewdell JW

更新日期：2003-01-05 00:00:00

abstract：:The P1a protein of the ipomovirus Cucumber vein yellowing virus is one of the self-cleavage serine proteases present in Potyviridae family members. P1a is located at the N-terminal end of the viral polyprotein, and is closely related to potyviral P1 protease. For its proteolytic activity, P1a requires a still unknown ...

journal_title：Virology

authors： Shan H,Pasin F,Valli A,Castillo C,Rajulu C,Carbonell A,Simón-Mateo C,García JA,Rodamilans B

更新日期：2015-02-01 00:00:00