Human Cytomegalovirus nuclear egress and secondary envelopment are negatively affected in the absence of cellular p53.

abstract：:Here, we evaluated the role of two host proteins, a Bromo domain containing RNA binding protein (BRP1) and Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), in the replication of Cucumber mosaic virus (CMV). LC-MS/MS analysis of host/viral proteins pull down against BRP1 from CMV-infected plants co-infiltrated with BR...

journal_title：Virology

authors： Chaturvedi S,Seo JK,Rao AL

更新日期：2016-07-01 00:00:00

abstract：:The Epstein-Barr virus open reading frame BLLF1 encodes the major envelope glycoproteins gp350 and gp220. Fragments of the gp350/220 gene were expressed in Escherichia coli in order to define regions of the polypeptide chain reacting with human sera. The C-terminal half of the protein was sufficient for recognition by...

journal_title：Virology

authors： Nuebling CM,Buck M,Boos H,von Deimling A,Mueller-Lantzsch N

更新日期：1992-11-01 00:00:00

abstract：:Groundnut bud necrosis virus induces necrotic symptoms in different hosts. Previous studies showed reactive oxygen species-mediated programmed cell death (PCD) resulted in necrotic symptoms. Transgenic expression of viral protein NSs mimics viral symptoms. Here, we showed a role for NSs in influencing oxidative burst ...

journal_title：Virology

authors： Singh A,Permar V,Jain RK,Goswami S,Kumar RR,Canto T,Palukaitis P,Praveen S

更新日期：2017-08-01 00:00:00

abstract：:Binding of simian virus 40 (SV40) large T antigen to human and calf thymus topoisomerase I (topo I) was readily detected by using modified enzyme-linked immunosorbent assays and immunoblots. In addition to WT T antigen, binding could also be readily demonstrated with T antigen fragments from the amino-terminal region ...

journal_title：Virology

authors： Simmons DT,Melendy T,Usher D,Stillman B

更新日期：1996-08-15 00:00:00

abstract：:PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis t...

journal_title：Virology

authors： Sommerfelt MA,Harkestad N,Hunter E

更新日期：2003-10-25 00:00:00

abstract：:Antibodies to the hepatitis C virus (HCV) core protein are present in the majority of patients with chronic HCV infection. To characterize the corresponding determinants, synthetic peptides and various deletion clones of the core gene expressed in Escherichia coli were used to test human anti-core positive sera or rab...

journal_title：Virology

authors： Goeser T,Müller HM,Ye J,Pfaff E,Theilmann L

更新日期：1994-12-01 00:00:00

abstract：:Wasting is a sign of various underlying disorders and is a common feature of cancer, sepsis, and AIDS. We have developed an in vivo model to study the various stages of wasting following infection of mice with lymphocytic choriomeningitis virus cl-13. Using this model we have identified four distinct stages of wasting...

journal_title：Virology

authors： Stamm A,Valentine L,Potts R,Premenko-Lanier M

更新日期：2012-04-10 00:00:00

abstract：:The red clover necrotic mosaic dianthovirus capsid protein is expressed in vivo from a subgenomic RNA (sgRNA) identical to the 3'-terminal 1.5 kb of RNA-1. The 5' leader sequence of the capsid protein sgRNA is 62 nucleotides, contains a 14-nucleotide putative promoter sequence homologous to the RNA-1 5' terminus, and ...

journal_title：Virology

authors： Zavriev SK,Hickey CM,Lommel SA

更新日期：1996-02-15 00:00:00

abstract：:Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular m...

journal_title：Virology

authors： Chua BA,Ngo JA,Situ K,Ramirez CM,Nakano H,Morizono K

更新日期：2018-02-01 00:00:00

abstract：:Resting peripheral blood mononuclear cells (PBMC) or purified T-cells can be induced to proliferate when cocultured in vitro with fixed HTLV-infected T-cells. This process of HTLV-dependent cellular activation and induction of proliferation has been considered distinctive because of an apparent independence from conve...

journal_title：Virology

authors： Martin TC,Southern PJ

更新日期：1996-07-15 00:00:00

abstract：:The cellular protein MDM2 can bind to the tumor suppressor gene product p53 and abrogate its transcriptional activity. In addition, p53 can regulate expression of the mdm2 gene. We and others have previously shown that p53 is present at high levels in adenovirus-transformed cells which express the larger E1B protein. ...

journal_title：Virology

authors： Grand RJ,Lecane PS,Owen D,Grant ML,Roberts S,Levine AJ,Gallimore PH

更新日期：1995-07-10 00:00:00

abstract：:The proteins encoded by open reading frame 3 (ORF3) of the umbraviruses pea enation mosaic virus-2 and tobacco mottle virus, like that of groundnut rosette virus, mediated the movement of viral RNA through the phloem of infected Nicotiana benthamiana or N. clevelandii plants when they were expressed from chimeric toba...

journal_title：Virology

authors： Ryabov EV,Robinson DJ,Taliansky M

更新日期：2001-09-30 00:00:00

abstract：:We cloned the complete complementary DNA of an isolate of the hepatitis C virus, HCV-S1, into a tetracycline-inducible expression vector and stably transfected it into two human hepatoma cell lines, Huh7 and HepG2. Twenty-six Huh7 and two HepG2-positive clones were obtained after preliminary screening. Two Huh7 (SH-7 ...

journal_title：Virology

authors： Lim SP,Soo HM,Tan YH,Brenner S,Horstmann H,MacKenzie JM,Ng ML,Lim SG,Hong Wj

更新日期：2002-11-10 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection can be inhibited by small molecules that target the CCR5 coreceptor. Here, we describe some properties of clonal viruses resistant to one such inhibitor, SCH-D, using both chimeric, infectious molecular clones and Env-pseudotypes. Studies using combinations of CCR5...

journal_title：Virology

authors： Pugach P,Marozsan AJ,Ketas TJ,Landes EL,Moore JP,Kuhmann SE

更新日期：2007-04-25 00:00:00

abstract：:Prostaglandin E₂ (PGE₂) is an arachidonic acid (AA)-derived signaling molecule that can influence host immune responses to infection or vaccination. In this study, we investigated PGE₂ production in vitro by cells infected with the poxvirus vaccine strain, modified vaccinia Ankara virus (MVA). Human THP-1 cells, murin...

journal_title：Virology

authors： Pollara JJ,Spesock AH,Pickup DJ,Laster SM,Petty IT

更新日期：2012-07-05 00:00:00

abstract：:Maturation of the arenavirus GP precursor (GPC) involves proteolytic processing by cellular signal peptidase and the proprotein convertase subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P), yielding a tripartite complex comprised of a stable signal peptide (SSP), the receptor-binding GP1, and the fusion-active ...

journal_title：Virology

authors： Burri DJ,Pasquato A,da Palma JR,Igonet S,Oldstone MB,Kunz S

更新日期：2013-02-05 00:00:00

abstract：:The 5' leader region of the HIV-1 RNA contains the major 5' splice site (ss) that is used in the production of all spliced viral RNAs. This splice-donor (SD) region can fold a stem-loop structure. We demonstrate that whereas stabilization of this SD hairpin reduces splicing efficiency, destabilization increases splici...

journal_title：Virology

authors： Mueller N,van Bel N,Berkhout B,Das AT

更新日期：2014-11-01 00:00:00

abstract：:Previous work (C.F. Spiropoulou and S.T. Nichol, 1993, J. Virol. 67, 3103-3110) has demonstrated the existence in cells infected with the New Jersey serotype of vesicular stomatitis virus (VSV) of two small carboxy-coterminal proteins encoded by the P mRNA. These proteins have been named C' and C. We are interested in...

journal_title：Virology

authors： Peluso RW,Richardson JC,Talon J,Lock M

更新日期：1996-04-15 00:00:00

abstract：:Cryphonectria parasitica, the causal agent of chestnut blight is controlled in Europe through natural spread of Cryphonectria hypovirus 1 (CHV1), a mycovirus able to induce hypovirulence to the host. In recent years C. parasitica was reported infecting Azerbaijani population of chestnut, but the presence of CHV1 still...

journal_title：Virology

authors： Forgia M,Isgandarli E,Aghayeva DN,Huseynova I,Turina M

更新日期：2021-01-15 00:00:00

abstract：:We have recently described the cloning of a portion of the hepatitis E virus (HEV) and confirmed its etiologic association with enterically transmitted (waterborne, epidemic) non-A, non-B hepatitis. The virus consists of a single-stranded, positive-sense RNA genome of approximately 7.5 kb, with a polyadenylated 3' end...

journal_title：Virology

authors： Tam AW,Smith MM,Guerra ME,Huang CC,Bradley DW,Fry KE,Reyes GR

更新日期：1991-11-01 00:00:00

abstract：:HeLa cell extracts containing wild-type copies of the minute virus of mice NS-1 polypeptide produced from a recombinant vaccinia virus vector could support the excision and replication of viral 5' telomeres from cloned concatemer junction fragments. Resolution did not occur if wild-type NS-1 was omitted from the extra...

journal_title：Virology

authors： Cotmore SF,Nuesch JP,Tattersall P

更新日期：1992-09-01 00:00:00

abstract：:Multiplication of frog virus 3 (FV 3) occurs in mammalian cells provided they are incubated at temperatures lower than 33 degrees. The expression of the viral genome at supraoptimal temperatures was followed by analyzing the polypeptides produced in CHO-infected cells and comparing with those obtained under restrictiv...

journal_title：Virology

authors： Cordier O,Tondre L,Aubertin AM,Kirn A

更新日期：1986-07-30 00:00:00

abstract：:The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the redu...

journal_title：Virology

authors： Alexandre KB,Mufhandu HT,London GM,Chakauya E,Khati M

更新日期：2016-10-01 00:00:00

abstract：:Rotavirus infection was studied in adult nude mice (BALB/c background), alpha beta or gamma delta and alpha beta/gamma delta T cell receptor (TCR) knockout (-/-) mice (C57BL/6 and C57BL/6 x 129 backgrounds), and SCID mice (C57BL/6 background). The gamma delta TCR -/- mice cleared infection just like control mice. All ...

journal_title：Virology

authors： Franco MA,Greenberg HB

更新日期：1997-11-24 00:00:00

abstract：:Nonspecific anti-inflammatory drugs have been purported to reduce the burden of severe influenza disease. We demonstrate that, unlike oseltamivir administration, simvastatin administration did not reduce morbidity, mortality, or viral load of mice infected with H1N1 or H5N1 viruses. No added benefit to the efficacy of...

journal_title：Virology

authors： Belser JA,Szretter KJ,Katz JM,Tumpey TM

更新日期：2013-04-25 00:00:00

abstract：:Attenuated mutants of Venezuelan equine encephalitis virus (VEE) were isolated by selection for rapid penetration of cultured cells (R. E. Johnston and J. F. Smith, 1988, Virology 162, 437-443). Sequence analysis of these mutants identified candidate attenuating mutations at four loci in the VEE E2 glycoprotein gene: ...

journal_title：Virology

authors： Davis NL,Powell N,Greenwald GF,Willis LV,Johnson BJ,Smith JF,Johnston RE

更新日期：1991-07-01 00:00:00

abstract：:Hepatitis delta virus (HDV) encodes only one protein, the hepatitis delta antigen (HDAg). Two forms of HDAg, a large (27 kDa) and a small (24 kDa) one, participate in the various steps of HDV replication. To further understand the properties of HDAg, we have constructed recombinant baculoviruses and expressed both for...

journal_title：Virology

authors： Hwang SB,Lee CZ,Lai MM

更新日期：1992-09-01 00:00:00

abstract：:Dendrolimus punctatus tetravirus (DpTV) belongs to the genus omegatetravirus of the Alphatetraviridae family. Sequence analysis predicts that DpTV replicase contains a putative helicase domain (Hel). However, the helicase activity in alphatetraviruses has never been formally determined. In this study, we determined th...

journal_title：Virology

authors： Wang Q,Han Y,Qiu Y,Zhang S,Tang F,Wang Y,Zhang J,Hu Y,Zhou X

更新日期：2012-11-25 00:00:00

abstract：:It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which ...

journal_title：Virology

authors： Davis CA,Parniak MA,Hughes SH

更新日期：2011-10-25 00:00:00

abstract：:Antigenic variation is a characteristic feature of lentiviral infection. The SIV/macaque model of AIDS provides an ideal system in which to investigate the molecular basis of antigenic variation. The purpose of this study was to genetically map the nucleotide changes in env that alter the neutralization phenotype of S...

journal_title：Virology

authors： Kinsey NE,Anderson MG,Unangst TJ,Joag SV,Narayan O,Zink MC,Clements JE

更新日期：1996-07-01 00:00:00