HIV-1 splicing at the major splice donor site is restricted by RNA structure.

abstract：:The sequence of the 1491 nucleotides found at the 3' end of the genome of the highly aphid-transmissible (HAT) isolate of tobacco etch virus (TEV) has been determined. The nucleotide sequence of the capsid protein gene has been identified and compared with the corresponding region of the not-aphid-transmissible (NAT) ...

journal_title：Virology

authors： Allison RF,Dougherty WG,Parks TD,Willis L,Johnston RE,Kelly M,Armstrong FB

更新日期：1985-12-01 00:00:00

abstract：:IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression o...

journal_title：Virology

authors： Xie Y,Chen R,Zhang X,Chen P,Liu X,Xie Y,Yu Y,Yang Y,Zou Y,Ge J,Chen H

更新日期：2011-12-05 00:00:00

abstract：:Crystals of Cowpea mosaic virus displaying a high degree of order have been grown in two different forms. Hexagonal crystals, space group P6(1)22 or P6(5)22 with a = 450 A and c = 1038 A containing six virus particles per cell, have been grown in sodium citrate buffer at pH 4.9. Each particle has four nearest neighbor...

journal_title：Virology

authors： White JM,Johnson JE

更新日期：1980-02-01 00:00:00

abstract：:Oral transmission of human immunodeficiency virus (HIV) in adult populations is rare. However, HIV spread across fetal/neonatal oropharyngeal epithelia could be important in mother-to-child transmission. Analysis of HIV transmission across polarized adult and fetal oral epithelial cells revealed that HIV transmigrates...

journal_title：Virology

authors： Tugizov SM,Herrera R,Veluppillai P,Greenspan D,Soros V,Greene WC,Levy JA,Palefsky JM

更新日期：2011-01-20 00:00:00

abstract：:The second smallest subgenomic messenger RNA, mRNA5, of the coronavirus infectious bronchitis virus includes in its "5' unique region" two separate open reading frames (5a and 5b), whose coding function has not so far been established, and thus it may represent a dicistronic messenger RNA. We report here that two poly...

journal_title：Virology

authors： Liu DX,Inglis SC

更新日期：1992-01-01 00:00:00

abstract：:Successful HIV-1 infection requires a number of specific stages leading to integration of the provirus. We previously suggested that members of the VPAC neuroendocrine receptor family may play a role in HIV-1 infection. We now show that stimulation of the VPAC2 receptor with specific agonists provides strong resistanc...

journal_title：Virology

authors： Bokaei PB,Ma XZ,Sakac D,Branch DR

更新日期：2007-05-25 00:00:00

abstract：:While HPV 16 variant lineages have been well characterized, the knowledge about HPV 18 variants is limited. In this study, HPV 18 nucleotide variations in the E2 hinge region were characterized by sequence analysis in 47 control and 51 tumor specimens. Fifty of these specimens were randomly selected for sequencing of ...

journal_title：Virology

authors： Arias-Pulido H,Peyton CL,Torrez-Martínez N,Anderson DN,Wheeler CM

更新日期：2005-07-20 00:00:00

abstract：:The major capsid protein of HPV, L1, assembles into pentamers that form a T = 7 icosahedral particle, but the location of the co-assembled minor capsid protein, L2, remains controversial. Several researchers have developed useful monoclonal antibodies targeting L2, but most react with linear epitopes toward the N-term...

journal_title：Virology

authors： Bywaters SM,Brendle SA,Biryukov J,Wang JW,Walston J,Milici J,Roden RB,Meyers C,Christensen ND

更新日期：2018-11-01 00:00:00

abstract：:Measles virus V protein represses genome replication through a poorly understood mechanism, which led us to investigate whether V protein might be an RNA-binding modulatory factor. Recombinant V protein, expressed from transfected HEp-2 cells or E. coli, formed protein-RNA complexes with poly-guanosine (poly-G) or pol...

journal_title：Virology

authors： Parks CL,Witko SE,Kotash C,Lin SL,Sidhu MS,Udem SA

更新日期：2006-04-25 00:00:00

abstract：:To gain new insights regarding the role of Ku, the DNA-PK DNA-binding component, during lentiviral DNA integration, we have investigated the HIV-1 replication in Ku80-depleted human cells. CEM4fx cells underexpressing the Ku80 factor were selected after transduction by a retroviral vector expressing the Ku80 full-leng...

journal_title：Virology

authors： Jeanson L,Subra F,Vaganay S,Hervy M,Marangoni E,Bourhis J,Mouscadet JF

更新日期：2002-08-15 00:00:00

abstract：:To be incorporated into progeny virions, the viral genome must be transported to the inner leaflet of the plasma membrane (PM) and accumulate there. Some viruses utilize lipid components to assemble at the PM. For example, simian virus 40 (SV40) targets the ganglioside GM1 and human immunodeficiency virus type 1 (HIV-...

journal_title：Virology

authors： Kakisaka M,Yamada K,Yamaji-Hasegawa A,Kobayashi T,Aida Y

更新日期：2016-09-01 00:00:00

abstract：:The prevalence of hepatitis B virus vaccine escape mutants has increased as a consequence of the introduction of global vaccination programs. Furthermore and as a consequence of the organization of the genome of hepatitis B virus (HBV) into overlapping reading frames, the selection of polymerase mutants during long-te...

journal_title：Virology

authors： Torresi J,Earnest-Silveira L,Deliyannis G,Edgtton K,Zhuang H,Locarnini SA,Fyfe J,Sozzi T,Jackson DC

更新日期：2002-02-15 00:00:00

abstract：:At least four hantavirus species cause disease with prominent renal involvement-hemorrhagic fever with renal syndrome (HFRS); and several hantavirus strains cause disease with significant pulmonary involvement-hantavirus pulmonary syndrome (HPS). The most prevalent and lethal hantaviruses associated with HFRS and HPS ...

journal_title：Virology

authors： Hooper JW,Custer DM,Smith J,Wahl-Jensen V

更新日期：2006-03-30 00:00:00

abstract：:CD8(+) T-lymphocytes from HIV-1 infected individuals express unidentified factors that suppress viral replication by inhibiting HIV-1 gene expression. We examined the role of epigenetics in modulating the HIV-1 suppressive factors expressed by primary CD8(+) T cells from subjects naturally controlling virus replicatio...

journal_title：Virology

authors： Saunders KO,Freel SA,Overman RG,Cunningham CK,Tomaras GD

更新日期：2010-09-15 00:00:00

abstract：:To clarify the causal relationship between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), we analyzed 386 unfixed biopsy specimens by blot hybridization at Tm -40 degrees C, targeting 38 skin and 42 genital HPVs. By the recognition of PstI, BanI, and MspI cleavage patterns, single genital, bu...

journal_title：Virology

authors： Matsukura T,Sugase M

更新日期：2001-04-25 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) UL37 open reading frame encodes a 120-kDa late (gamma 1) phosphoprotein in infected cells. Analysis of isolated mature HSV virions and light particles revealed that the UL37 protein is a component of the virion. Detergent solubilization and protease digestion experiments suggest...

journal_title：Virology

authors： Schmitz JB,Albright AG,Kinchington PR,Jenkins FJ

更新日期：1995-02-01 00:00:00

abstract：:The International Human Papillomavirus (HPV) Reference Center supports quality and order in HPV research and diagnostics. Notably, the center assigns HPV type numbers to novel HPV types, maintains a reference clone repository, and issues international proficiency panels for HPV genotyping. The established HPV types, c...

journal_title：Virology

authors： Mühr LSA,Eklund C,Dillner J

更新日期：2018-06-01 00:00:00

abstract：:During the productive phase of chronic hepadnaviral infections, virion DNA synthesis occurs in the cytoplasm of the infected hepatocyte, but viral RNA is synthesized in the nucleus, apparently from a covalently closed, circular (CCC) viral DNA. J. Tuttleman, C. Pourcel, and J. Summers (1986a, Cell 47, 451-460) have sh...

journal_title：Virology

authors： Wu TT,Coates L,Aldrich CE,Summers J,Mason WS

更新日期：1990-03-01 00:00:00

abstract：:A cytopathic infectious agent was isolated from the kidneys of an apparently healthy tree shrew (Tupaia belangeri) that had been captured in the area around Bangkok. The infectivity was propagated in Tupaia fibroblast and kidney cell cultures. Paramyxovirus-like pleomorphic enveloped particles and helical nucleocapsid...

journal_title：Virology

authors： Tidona CA,Kurz HW,Gelderblom HR,Darai G

更新日期：1999-06-05 00:00:00

abstract：:Monoclonal antibodies to the matrix or E1 glycoprotein of mouse hepatitis virus (MHV) were tested for their ability to protect mice from a normally lethal challenge of MHV-4. Four antibodies were tested, and two of these, J.1.3 and J.3.9, were protective. Protection did not correlate with virus neutralization in vitro...

journal_title：Virology

authors： Fleming JO,Shubin RA,Sussman MA,Casteel N,Stohlman SA

更新日期：1989-01-01 00:00:00

abstract：:The function of rice dwarf virus segment 11 and the corresponding segments of other phytoreoviruses is not yet determined. The amino acid sequence of Pns11, encoded by segment 11, contains a putative zinc finger and five flanking basic regions at the C-terminus. The full-length Pns11 protein and three truncated deriva...

journal_title：Virology

authors： Xu H,Li Y,Mao Z,Li Y,Wu Z,Qu L,An C,Ming X,Schiemann J,Casper R,Chen Z

更新日期：1998-01-20 00:00:00

abstract：:Many viruses activate the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, thereby modulating diverse downstream signaling pathways associated with antiapoptosis, proliferation, cell cycling, protein synthesis and glucose metabolism, in order to augment their replication. To date, the role of the PI3K-Akt p...

journal_title：Virology

authors： Xiao W,Yang Y,Weng Q,Lin T,Yuan M,Yang K,Pang Y

更新日期：2009-08-15 00:00:00

abstract：:Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K242 and K244 are resp...

journal_title：Virology

authors： Tan CW,Sam IC,Lee VS,Wong HV,Chan YF

更新日期：2017-01-15 00:00:00

abstract：:The satellite RNA of Bamboo mosaic virus (satBaMV) contains on open reading frame for a 20-kDa protein that is flanked by a 5'-untranslated region (UTR) of 159 nucleotides (nt) and a 3'-UTR of 129 nt. A secondary structure was predicted for the 5'-UTR of satBaMV RNA, which folds into a large stem-loop (LSL) and a smal...

journal_title：Virology

authors： Annamalai P,Hsu YH,Liu YP,Tsai CH,Lin NS

更新日期：2003-06-20 00:00:00

abstract：:We report here the nonenzymatic self-ligation of transcripts corresponding to the peach latent mosaic viroid (PLMVd). This is the first description of this process with viroid sequences, although it has been reported to occur with human hepatitis delta virus RNA. Self-ligation occurs when the 5'-hydroxyl and the 2',3'...

journal_title：Virology

authors： Lafontaine D,Beaudry D,Marquis P,Perreault JP

更新日期：1995-10-01 00:00:00

abstract：:The HIV-2 viral accessory protein Vpx is related to, but distinct from the Vpr protein of HIV-1. Vpx is packaged into virions and as a component of the viral preintegration complex (PIC) is required for efficient virus replication in non-dividing cells. We have previously reported that the minimal transferable region ...

journal_title：Virology

authors： Belshan M,Mahnke LA,Ratner L

更新日期：2006-03-01 00:00:00

abstract：:The adenine DNA methyltransferase M.CviRI (TGCmA) gene from chlorella virus XZ-6E was cloned into the Autographa californica nuclear polyhedrosis virus (AcMNPV) genome and expressed in Spodoptera frugiperda insect cells under the control of two tandemly arranged viral promoters, the early ETL promoter and the late pol...

journal_title：Virology

authors： Xia Y,Van Etten JL,Dobos P,Ling YY,Krell PJ

更新日期：1993-10-01 00:00:00

abstract：:The epithelium of the cervix uteri has been reported to be frequently coinfected with both human papillomaviruses (HPV) and helper virus-dependent adenoassociated viruses (AAV). Seroepidemiological data suggest that AAV infection could inhibit cervical cancer that is caused by specific ("high-risk") types of papilloma...

journal_title：Virology

authors： Walz CM,Correa-Ochoa MM,Müller M,Schlehofer JR

更新日期：2002-02-01 00:00:00

abstract：:The biological significance of protective CD8 T-cell-mediated responses against non-traditional alternative reading frame epitopes remains relatively unknown. Cytolytic CD8 T cells (CTL) specific for a non-traditional cryptic MHC class I epitope, SYNTGRFPPL, are critically involved in the protection of mice during inf...

journal_title：Virology

authors： Rutkowski MR,Ho O,Green WR

更新日期：2009-08-01 00:00:00

abstract：:The single-cell ELISPOT assay was used to determine the frequency and isotype commitment of virus-specific antibody-forming cells (AFC) at different anatomical locations following intranasal Sendai virus infection of C57BL/6 and 129/Sv mice. AFC responses in the mediastinal and cervical lymph nodes showed sharp increa...

journal_title：Virology

authors： Sangster M,Hyland L,Sealy R,Coleclough C

更新日期：1995-02-20 00:00:00