当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor.

HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor.

Abstract：

:Successful HIV-1 infection requires a number of specific stages leading to integration of the provirus. We previously suggested that members of the VPAC neuroendocrine receptor family may play a role in HIV-1 infection. We now show that stimulation of the VPAC2 receptor with specific agonists provides strong resistance to HIV-1 infection. Daily stimulation of VPAC2, but not VPAC1 or PAC1, resulted in up to 90% inhibition of X4 or R5 productive infections in either cell lines or PBMCs. VPAC2 agonist stimulation had no effect on cell surface co-receptors, the rate of apoptotic cells, or HIV-1 entry or reverse transcription of viral RNA. However, we provide evidence that VPAC2-specific agonists inhibit HIV-1 infection through an inhibitory effect on the ability of the HIV-1 cDNA to integrate into the host DNA. These data reveal that VPAC2 agonists are appropriate candidates for further study as possible treatments aimed at the amelioration of HIV/AIDS.

journal_name

Virology

journal_title

Virology

authors

Bokaei PB,Ma XZ,Sakac D,Branch DR

doi

10.1016/j.virol.2006.12.012

subject

Has Abstract

pub_date

2007-05-25 00:00:00

pages

38-49

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(06)00900-7

journal_volume

362

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41.

    abstract：:Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding to the leucine zipper motif in the HR1 alpha-helix and to another motif within HR2 region, hosting 2F5 and 4E10 epitope. This study aimed at reproducing such protective responses through VLP vaccination...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.05.005

    authors： Pastori C,Tudor D,Diomede L,Drillet AS,Jegerlehner A,Röhn TA,Bomsel M,Lopalco L

    更新日期：2012-09-15 00:00:00

  • Human recombinant neutralizing antibodies against hantaan virus G2 protein.

    abstract：:Old world hantaviruses, causing hemorrhagic fever with renal syndrome (HFRS), still present a public health problem in Asia and Eastern Europe. The majority of cases has been recorded in China. The aim of our study was to generate human recombinant neutralizing antibodies to a hantavirus by phage display technology. T...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(02)00094-6

    authors： Koch J,Liang M,Queitsch I,Kraus AA,Bautz EK

    更新日期：2003-03-30 00:00:00

  • Deletion and substitution analysis defines regions and residues within the phosphoprotein of bovine respiratory syncytial virus that affect transcription, RNA replication, and interaction with the nucleoprotein.

    abstract：:The phosphoprotein (P) of bovine respiratory syncytial virus (BRSV) is a multifunctional protein that plays a central role in transcription and replication of the viral genomic RNA. To investigate the domains and specific residues involved in different activities of the P protein, we generated a total of 22 deletion a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.0960

    authors： Khattar SK,Yunus AS,Collins PL,Samal SK

    更新日期：2001-07-05 00:00:00

  • Chimeric papillomavirus-like particles.

    abstract：:We have constructed chimeric papillomavirus-like particles (CVLPs) by replacing the 34-carboxy-terminal amino acids of the HPV 16 L1 protein with various parts of the HPV 16 E7 protein. Chimeric proteins were expressed by recombinant baculoviruses and analyzed by electron microscopy for their ability to assemble into ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8591

    authors： Müller M,Zhou J,Reed TD,Rittmüller C,Burger A,Gabelsberger J,Braspenning J,Gissmann L

    更新日期：1997-07-21 00:00:00

  • The effect of overproduction of nonstructural proteins on alphavirus plus-strand and minus-strand RNA synthesis.

    abstract：:We determined the effect of the overproduction of viral nonstructural proteins on alphavirus plus-strand and minus-strand RNA synthesis. Because alphavirus minus-strand synthesis ceases normally at 3 to 4 hr postinfection and requires continuous protein synthesis [D. L. Sawicki and S. G. Sawicki, J. Virol. 34, 108-118...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90157-1

    authors： Sawicki SG,Sawicki DL

    更新日期：1986-07-30 00:00:00

  • Subviral agents associated with plant single-stranded DNA viruses.

    abstract：:Begomoviruses (family Geminiviridae) are responsible for many economically important crop diseases worldwide. The majority of these diseases are caused by bipartite begomovirus infections, although a rapidly growing number of diseases of the Old World are associated with monopartite begomoviruses. With the exception o...

    journal_title：Virology

    pub_type： 杂志文章,随机对照试验,评审

    doi：10.1016/j.virol.2005.09.042

    authors： Briddon RW,Stanley J

    更新日期：2006-01-05 00:00:00

  • Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo.

    abstract：:The M128L myxoma virus gene expresses a five-membrane spanning cell surface protein with significant amino acid homology to the cellular CD47 proteins. CD47, also called integrin-associated protein (IAP), is associated with the modulation of leukocyte adhesion, motility, activation, and phagocytosis. Creation of an M1...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.03.037

    authors： Cameron CM,Barrett JW,Mann M,Lucas A,McFadden G

    更新日期：2005-06-20 00:00:00

  • Selective inhibition of formation of suppressor glutamine tRNA in Moloney murine leukemia virus-infected NIH-3T3 cells by Avarol.

    abstract：:Avarol is a sesquiterpenoid hydroquinone, which displays no inhibitory potencies on mammalian DNA polymerases alpha, beta, and gamma, on mammalian RNA polymerases I, II, and III, or on reverse transcriptases from Moloney murine leukemia virus (Mo-MuLV) and from HIV. For a further elucidation of the antiviral effect of...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90596-x

    authors： Kuchino Y,Nishimura S,Schröder HC,Rottmann M,Müller WE

    更新日期：1988-08-01 00:00:00

  • Analysis of the function of cytoplasmic fibers formed by the rubella virus nonstructural replicase proteins.

    abstract：:The P150 and P90 replicase proteins of rubella virus (RUBV), a plus-strand RNA Togavirus, produce a unique cytoplasmic fiber network resembling microtubules. Pharmacological and mutagenic approaches were used to determine if these fibers functioned in virus replication. The pharmacological approach revealed that micro...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.025

    authors： Matthews JD,Tzeng WP,Frey TK

    更新日期：2010-10-25 00:00:00

  • 3'-terminal nucleotide sequences important for the accumulation of cowpea mosaic virus M-RNA.

    abstract：:The location of nucleotide sequences important in determining the extent of cowpea mosaic virus M-RNA accumulation in cowpea protoplasts has been analyzed by deletion mutagenesis of full-length cDNA clones from which infectious transcripts can be produced in vitro. The results suggest that cis-acting sequences which d...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1175

    authors： Rohll JB,Holness CL,Lomonossoff GP,Maule AJ

    更新日期：1993-04-01 00:00:00

  • Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.

    abstract：:The host innate response to viral infection includes the production of interferons, which is dependent on the coordinated activity of multiple transcription factors. Herpes simplex virus 1 (HSV-1) has been shown to block efficient interferon expression by multiple mechanisms. We and others have demonstrated that HSV-1...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.10.028

    authors： Melroe GT,Silva L,Schaffer PA,Knipe DM

    更新日期：2007-04-10 00:00:00

  • Genetic variation among dengue 2 viruses of different geographic origin.

    abstract：:Genetic variation in dengue 2 isolates from various geographic areas was examined by oligonucleotide fingerprinting of the 40 S genome RNA. Oligonucleotide maps of geographically isolated and epidemiologically unrelated viruses were very distinct. Direct comparison of the oligonucleotide map of the dengue 2 prototype ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90255-6

    authors： Trent DW,Grant JA,Rosen L,Monath TP

    更新日期：1983-07-30 00:00:00

  • Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers.

    abstract：:The co-existence of hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (HBsAb) in serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with HBsAg-amino acid (aa) substitutions. However, the aa pattern of HBV-reverse transcriptase (RT) and the clinical settings associated with this ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.05.012

    authors： Colson P,Borentain P,Motte A,Henry M,Moal V,Botta-Fridlund D,Tamalet C,Gérolami R

    更新日期：2007-10-10 00:00:00

  • Abolition of hCAR-dependent cell tropism using fiber knobs of Atadenovirus serotypes.

    abstract：:Most adenoviral vectors use in gene therapy protocols derive from species C. However, expression of the primary receptor (human Coxsackievirus and Adenovirus receptor, hCAR) for these AdV is variable on cancer cells. In vivo targeting of a therapeutic gene to specific cells has then become a major issue in gene therap...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.12.023

    authors： Renaut L,Colin M,Leite JP,Benko M,D'Halluin JC

    更新日期：2004-04-10 00:00:00

  • Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities.

    abstract：:A collection of TK+, ACV-resistant mutants of herpes simplex virus type 1 (HSV-1) has been derived using a selection system based on biochemically transformed cells. Evidence is presented suggesting that most of these mutants induce resistant DNA polymerase activities and are thus likely to express variant DNA polymer...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90009-1

    authors： Larder BA,Darby G

    更新日期：1985-10-30 00:00:00

  • The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine.

    abstract：:Segment 7 (M) of the cold-adapted live influenza A virus vaccine plays a primary role in the ability of this virus to interfere with the replication of wild-type influenza A viruses. This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influenza A/Ann Arbor/6/60 (H...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90011-y

    authors： Whitaker-Dowling P,Zvolenski R,Youngner JS

    更新日期：1991-01-01 00:00:00

  • The genes encoding the DNA binding protein and the 23K protease of adenovirus types 40 and 41.

    abstract：:The adenovirus (Ad) single-stranded DNA binding protein (DBP) is a multifunctional protein. It is thought to consist of two domains, the amino-terminal domain involved in host-range determination and the carboxyl-terminal domain functioning in DNA replication and DNA binding. We have determined the nucleotide sequence...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90227-9

    authors： Vos HL,van der Lee FM,Reemst AM,van Loon AE,Sussenbach JS

    更新日期：1988-03-01 00:00:00

  • Multiple origins of the complementary defective genomes of RF and origin proximal sequences of GS, two human papovavirus isolates.

    abstract：:It has previously been shown that the genome of RF virus, a variant of the human papovavirus, BK, consists of two DNA species, one (R1a) with a deletion corresponding to the early and the other (R2) with a deletion corresponding to the late region of BKV (A. Pater, M.M. Pater, and G. di Mayorca (1980). J. Virol. 36, 4...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90509-3

    authors： Pater A,Pater MM,Chang LS,Slawin K,Di Mayorca G

    更新日期：1983-12-01 00:00:00

  • Physical characterization of the genome of feline herpesvirus-1.

    abstract：:The physical structure of the genome of feline herpesvirus-1, a major upper respiratory tract pathogen of cats, was studied. Purified FHV-1 DNA was analyzed by restriction endonuclease and gamma 5' exonuclease digestion, blot hybridization, and electron microscopy. To facilitate further studies, nine bacteriophage clo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90439-3

    authors： Rota PA,Maes RK,Ruyechan WT

    更新日期：1986-10-15 00:00:00

  • Identification of a set of proteins (C' and C) encoded by the bicistronic P gene of the Indiana serotype of vesicular stomatitis virus and analysis of their effect on transcription by the viral RNA polymerase.

    abstract：:Previous work (C.F. Spiropoulou and S.T. Nichol, 1993, J. Virol. 67, 3103-3110) has demonstrated the existence in cells infected with the New Jersey serotype of vesicular stomatitis virus (VSV) of two small carboxy-coterminal proteins encoded by the P mRNA. These proteins have been named C' and C. We are interested in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0202

    authors： Peluso RW,Richardson JC,Talon J,Lock M

    更新日期：1996-04-15 00:00:00

  • Functional and molecular characterization of African swine fever virus mutants resistant to phosphonoacetic acid.

    abstract：:African swine fever virus (ASFV) growth and plaque formation were inhibited by phosphonoacetic acid (PAA) concentrations of 200 micrograms/ml or more. One spontaneous mutant and two mutants isolated from mutagenized virus were resistant to PAA inhibition and showed practically normal viral DNA synthesis in the presenc...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.9953

    authors： Marques MI,Costa JV

    更新日期：1995-12-01 00:00:00

  • Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120.

    abstract：:Neutralizing antibodies (Nabs) are thought to play an important role in prevention and control of HIV-1 infection and should be targeted by an AIDS vaccine. It is critical to understand how HIV-1 induces Nabs by analyzing viral sequences in both tested viruses and sera. Neutralization susceptibility to antibodies in a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.09.031

    authors： Kirchherr JL,Hamilton J,Lu X,Gnanakaran S,Muldoon M,Daniels M,Kasongo W,Chalwe V,Mulenga C,Mwananyanda L,Musonda RM,Yuan X,Montefiori DC,Korber BT,Haynes BF,Gao F

    更新日期：2011-01-20 00:00:00

  • Lineage structures in the genome sequences of three Epstein-Barr virus strains.

    abstract：:Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were ident...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.10.009

    authors： McGeoch DJ,Gatherer D

    更新日期：2007-03-01 00:00:00

  • Rapid establishment of stable retroviral packaging cells and recombinant susceptible target cell lines employing novel transposon vectors derived from Sleeping Beauty.

    abstract：:Viral vector particles derived from murine leukemia virus (MLV) mediate highly efficient stable gene transfer used in gene therapeutic approaches and in the generation of transgenic cell lines. However, the establishment of stable viral packaging cells (VPCs) is a time-consuming challenge. To overcome this limitation,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.02.014

    authors： Berg K,Schäfer VN,Bartnicki N,Eggenschwiler R,Cantz T,Stitz J

    更新日期：2019-05-01 00:00:00

  • Equine herpesvirus 1 (EHV-1) glycoprotein M: effect of deletions of transmembrane domains.

    abstract：:Equine herpesvirus 1 (EHV-1) recombinants that carry either a deletion of glycoprotein M (gM) or express mutant forms of gM were constructed. The recombinants were derived from strain Kentucky A (KyA), which also lacks genes encoding gE and gI. Plaques on RK13 cells induced by the gM-negative KyA were reduced in size ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0664

    authors： Seyboldt C,Granzow H,Osterrieder N

    更新日期：2000-12-20 00:00:00

  • Study of genetic reassortment between two human rotaviruses.

    abstract：:Eight different human rotavirus strains were adapted to replicate in cell culture. In vitro, rotavirus genetic reassortment has been performed between two virus strains, one with a long pattern of segmented genomic RNAs and the other with a short pattern in the electrophoretic mobility of genomic RNAs. This genetic re...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90381-7

    authors： Garbarg-Chenon A,Bricout F,Nicolas JC

    更新日期：1984-12-01 00:00:00

  • Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation.

    abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB) promotes virion entry into cells by fusing the virion envelope with the cellular membrane. We recently reported that UB cells (U373 glioblastoma cells constructed to produce HCMV gB constitutively) form multinucleate syncytia that are dependent on the density of gB in t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1290

    authors： Tugizov S,Wang Y,Qadri I,Navarro D,Maidji E,Pereira L

    更新日期：1995-06-01 00:00:00

  • Glycoprotein E (gE) specified by bovine herpesvirus type 5 (BHV-5) enables trans-neuronal virus spread and neurovirulence without being a structural component of enveloped virions.

    abstract：:Bovine herpesvirus 5 (BHV-5) is a neurovirulent alpha-herpesvirus that causes fatal encephalitis in calves. We previously demonstrated that deletion of a glycine-rich epitope in the gE ectodomain dramatically reduced BHV-5 neurovirulence. To investigate the role of gE cytoplasmic tail sequences in the neuropathogenesi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.03.040

    authors： Al-Mubarak A,Simon J,Coats C,Okemba JD,Burton MD,Chowdhury SI

    更新日期：2007-09-01 00:00:00

  • Quasispecies, error catastrophe, and the antiviral activity of ribavirin.

    abstract：:Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30 year history, the mechanism of action of this compound remains unclear and somewhat controversial. Recent data suggest the possibility that the activity of ribavirin against RNA viruses is a reflection of incorporation of r...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1006/viro.2002.1487

    authors： Graci JD,Cameron CE

    更新日期：2002-07-05 00:00:00

  • Clinical isolates of dengue virus with distinctive susceptibility to nitric oxide radical induce differential gene responses in THP-1 cells.

    abstract：:In the present study, 10 clinical isolates of dengue virus were selected according to their susceptibility to the inhibitory effect of nitric oxide radical, NO. Five of them are nitric oxide-susceptible viruses while the other five are nitric oxide-resistant viruses. These isolates were investigated to identify geneti...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.03.030

    authors： Ubol S,Chareonsirisuthigul T,Kasisith J,Klungthong C

    更新日期：2008-07-05 00:00:00