Abstract：
:Eight different human rotavirus strains were adapted to replicate in cell culture. In vitro, rotavirus genetic reassortment has been performed between two virus strains, one with a long pattern of segmented genomic RNAs and the other with a short pattern in the electrophoretic mobility of genomic RNAs. This genetic reassortment was detectable despite the lack of selective markers in the parental strains. Moreover, some of the reassorted virus exhibited mixed RNA patterns containing extra genomic RNAs resembling those found in clinical specimens. These viruses with mixed RNA band patterns could segregate their supplementary segments after successive passages in cell culture. Finally it has been shown that classification of genomic segments in long and short electropherotypes should not only be based on their relative size but also by their ability to reassort with the genetically equivalent segment.
journal_name
Virologyjournal_title
Virologyauthors
Garbarg-Chenon A,Bricout F,Nicolas JCdoi
10.1016/0042-6822(84)90381-7subject
Has Abstractpub_date
1984-12-01 00:00:00pages
358-65issue
2eissn
0042-6822issn
1096-0341journal_volume
139pub_type
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