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Progress and Perspectives on HIV-1 microbicide development.

Abstract：

:The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the reduction of infection rates in some countries, there is still need for effective prevention methods against the virus. One of these methods for preventing sexual transmission in women is the use of microbicides. In this review we provide a summary of the progress made toward the discovery of affordable and effective HIV-1 microbicides and suggest future directions. We show that there is a wide range of compounds that have been proposed as potential microbicides. Although most of them have so far failed to show protection in humans, there are many promising ones currently in pre-clinical studies and in clinical trials.

journal_name

Virology

journal_title

Virology

authors

Alexandre KB,Mufhandu HT,London GM,Chakauya E,Khati M

doi

10.1016/j.virol.2016.07.004

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

69-80

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(16)30171-4

journal_volume

497

pub_type

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