Abstract:
:N-tropic murine leukemia viruses have been observed in connection with radiation-induced osteosarcomagenesis in BALB/c mice. We have investigated the bone disease-inducing potential of molecularly cloned, BALB/c-derived N-tropic viruses in the random-bred NMRI mouse strain. The germ-line virus and an exogenous virus isolate were found to induce high incidences of osteopetrosis and lymphomas and a lower incidence of osteomas. Two viruses derived from somatically acquired proviruses of independent radiation-induced osteosarcomas induced lower incidence of osteopetrosis and lymphomas. Nucleotide sequence analysis of the long terminal repeat regions and RNase T1 fingerprint analysis revealed only few differences between the isolates. The possible involvement of N-tropic murine leukemia viruses in radiation-induced osteosarcomagenesis in the BALB/c mouse strain is discussed.
journal_name
Virologyjournal_title
Virologyauthors
Pedersen L,Strauss PG,Schmidt J,Luz A,Erfle V,Jørgensen P,Kjeldgaard NO,Pedersen FSdoi
10.1016/0042-6822(90)90171-msubject
Has Abstractpub_date
1990-12-01 00:00:00pages
931-5issue
2eissn
0042-6822issn
1096-0341journal_volume
179pub_type
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