Abstract:
:Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.
journal_name
Virologyjournal_title
Virologyauthors
Mahmoud NF,Jasirwan C,Kanemoto S,Wakata A,Wang B,Hata Y,Nagamata S,Kawabata A,Tang H,Mori Ydoi
10.1016/j.virol.2015.12.018subject
Has Abstractpub_date
2016-03-01 00:00:00pages
1-5eissn
0042-6822issn
1096-0341pii
S0042-6822(15)00539-5journal_volume
490pub_type
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