当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > The two nonstructural proteins from wheat dwarf virus involved in viral gene expression and replication are retinoblastoma-binding proteins.

The two nonstructural proteins from wheat dwarf virus involved in viral gene expression and replication are retinoblastoma-binding proteins.

Abstract：

:Tumor-inducing viruses like simian virus 40 or the human adenovirus produce oncoproteins which interfere with the cellular retinoblastoma (Rb) tumor-suppressor protein to create an appropriate molecular environment in the nucleus for viral transcription and replication. Such a strategy has been considered to be restricted to animal viruses. Here we demonstrate that plant viruses may use similar mechanisms for recruiting host factors. Wheat dwarf virus (WDV) encodes two potential nonstructural proteins, C1 and C1:C2, both containing the consensus Rb-binding motif LeuXCysXGlu that allows the oncoproteins from animal viruses to inactivate Rb. C1:C2 is a key determinant of viral replication and V(virion)-sense expression. Using a yeast two-hybrid protein assay, we demonstrate for the first time that the C1:C2 protein from WDV interacts with a retinoblastoma protein, providing an explanation for the previously observed dependence of viral replication on an intact Rb-binding motif. We also show that C1, for which no function had been demonstrated, is required for V-sense gene expression. This suggests that V-sense expression might be dependent on the interaction of C1 with Rb. Our findings provide further evidence for the presence of transforming-like proteins in a plant virus and will help to explain the production of symptoms in a plant viral infection through a mechanism mediated by a key regulator of cell cycle and differentiation.

journal_name

Virology

journal_title

Virology

authors

Collin S,Fernández-Lobato M,Gooding PS,Mullineaux PM,Fenoll C

doi

10.1006/viro.1996.0256

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

324-9

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(96)90256-1

journal_volume

219

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Human cytomegalovirus polypeptides stimulate neutralizing antibody in vivo.

    abstract：:At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90215-6

    authors： Rasmussen L,Mullenax J,Nelson M,Merigan TC

    更新日期：1985-08-01 00:00:00

  • Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation.

    abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB) promotes virion entry into cells by fusing the virion envelope with the cellular membrane. We recently reported that UB cells (U373 glioblastoma cells constructed to produce HCMV gB constitutively) form multinucleate syncytia that are dependent on the density of gB in t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1290

    authors： Tugizov S,Wang Y,Qadri I,Navarro D,Maidji E,Pereira L

    更新日期：1995-06-01 00:00:00

  • Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus.

    abstract：:Piglets infected in utero with porcine reproductive and respiratory syndrome virus (PRRSV) are born severely immunocompromised. In this article we more closely examine the effects of in utero PRRSV infection on circulating and thymic T cell populations. Numbers of CD4+, CD8+, and dual-positive lymphocytes were quantit...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1650

    authors： Feng WH,Tompkins MB,Xu JS,Brown TT,Laster SM,Zhang HX,McCaw MB

    更新日期：2002-10-25 00:00:00

  • GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine.

    abstract：:Single intradermal or intramuscular inoculations of GM-CSF DNA with the DNA prime for a simian-human immunodeficiency virus (SHIV)-89.6 vaccine, which consists of DNA priming followed by modified vaccinia Ankara (MVA) boosting, increased protection of both the blood and intestines against the acute phase of an intrare...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.07.017

    authors： Lai L,Vödrös D,Kozlowski PA,Montefiori DC,Wilson RL,Akerstrom VL,Chennareddi L,Yu T,Kannanganat S,Ofielu L,Villinger F,Wyatt LS,Moss B,Amara RR,Robinson HL

    更新日期：2007-12-05 00:00:00

  • In vivo infection of ramified microglia from adult cat central nervous system by feline immunodeficiency virus.

    abstract：:Infection of microglial cells by the human immunodeficiency virus (HIV) is supposed to play an important role in the pathogenesis of AIDS-related central nervous system (CNS) complications. So far, however, experimental data about interactions between HIV and ramified microglia from the adult CNS were only occasionall...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0152

    authors： Hein A,Martin JP,Koehren F,Bingen A,Dörries R

    更新日期：2000-03-15 00:00:00

  • The endogenous langur type D retrovirus PO-1-Lu and its exogenous counterparts in macaque and langur monkeys.

    abstract：:PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(03)00548-8

    authors： Sommerfelt MA,Harkestad N,Hunter E

    更新日期：2003-10-25 00:00:00

  • Bovine aortic endothelial cells are susceptible to hantavirus infection; a new aspect in hantavirus ecology.

    abstract：:Hantaviruses are enveloped RNA viruses that belong to the family Bunyaviridae. They are the causative agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Hantaviruses show a worldwide distribution with specific rodent species as natural hosts. It is known that rodents can tr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.09.006

    authors： Muranyi W,Kehm R,Bahr U,Müller S,Handermann M,Darai G,Zeier M

    更新日期：2004-01-05 00:00:00

  • Bovine papillomavirus type 1 (BPV1) and BPV2 are closely related serotypes.

    abstract：:Infection with bovine papillomavirus type 1 (BPV1) or BPV2 induces fibropapillomas in cows and skin sarcoids in horses. Prophylactic vaccination targeting BPV1 and BPV2 may reduce the incidence of these economically important diseases. The L1 major capsid proteins of BPV1 and BPV2 were expressed in Sf-9 insect cells a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.07.036

    authors： Shafti-Keramat S,Schellenbacher C,Handisurya A,Christensen N,Reininger B,Brandt S,Kirnbauer R

    更新日期：2009-10-10 00:00:00

  • Detection of visna virus antigens and RNA in glial cells in foci of demyelination.

    abstract：:Visna is a slow virus infection of sheep in which the characteristic pathological change is demyelination in foci of inflammation. The latter is thought to be the result of an immunopathological process directed against cellular and antigenic targets that have been difficult to define because of restricted viral gene ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90264-8

    authors： Stowring L,Haase AT,Petursson G,Georgsson G,Palsson P,Lutley R,Roos R,Szuchet S

    更新日期：1985-03-01 00:00:00

  • Pathogenesis of the slow disease of the central nervous system associated with wild mouse virus. III. Role of input virus and MCF recombinants in disease.

    abstract：:Inbred mice bearing the FV-1n marker when inoculated at birth with an ecotropic murine leukemia virus (WM 1504-E) obtained from wild mice develop a progressive central nervous system (CNS) disease manifested by hindlimb paralysis and incoordination that begins by 6 to 7 weeks of age. Studies of infected SWR/J mice at ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90326-4

    authors： Oldstone MB,Jensen F,Elder J,Dixon FJ,Lampert PW

    更新日期：1983-07-15 00:00:00

  • ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships.

    abstract：:A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous chimpanzee provirus, CH2. DNA sequencing within the clone and comparisons with other retro...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90347-7

    authors： O'Connell C,O'Brien S,Nash WG,Cohen M

    更新日期：1984-10-30 00:00:00

  • Mitigation of variation observed in a peripheral blood mononuclear cell (PBMC) based HIV-1 neutralization assay by donor cell pooling.

    abstract：:Cultured primary peripheral blood mononuclear cells (PBMC) represent a potentially physiologic in vitro model of HIV-1 infection, but assessment of antibody-mediated HIV-1 neutralization using PBMC has been hindered by donor variability and lack of a sustainable individual PBMC source. To advance this model for HIV va...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.09.014

    authors： Wieczorek L,Brown BK,Delsarto Macedo C,Wesberry-Schmierer M,Ngauy V,Rosa Borges A,Michael NL,Marovich MA,Montefiori DC,Polonis VR

    更新日期：2013-12-01 00:00:00

  • Differential growth of human enteric adenovirus 41 (TAK) in continuous cell lines.

    abstract：:Differing reports exist about the replication of human enteric adenoviruses (EnAds) in various cell lines. There was a suggestion that EnAds are defective, do not grow on primary human diploid cells, and behave like Ad host-range mutants, i.e., they require early gene products from other Ad types for efficient growth....

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90072-y

    authors： Pieniazek D,Pieniazek NJ,Macejak D,Coward J,Rayfield M,Luftig RB

    更新日期：1990-01-01 00:00:00

  • The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.

    abstract：:We have previously showed that equine arteritis virus (EAV), an arterivirus, induces apoptosis in vitro. To determine the caspase activation pathways involved in EAV-induced apoptosis, target cells were treated with peptide inhibitors of apoptosis Z-VAD-FMK (pan-caspase inhibitor), Z-IETD-FMK (caspase-8-specific inhib...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.05.023

    authors： St-Louis MC,Archambault D

    更新日期：2007-10-10 00:00:00

  • Functional dissection of the ie2 gene product of the baculovirus Autographa californica nuclear polyhedrosis virus.

    abstract：:The PstI-N genomic fragment of Autographa californica nuclear polyhedrosis virus (AcNPV) encodes an immediate-early protein, IE2, that functions as a promiscuous transactivator of other early viral promoters and heterologous promoters both in vivo and in vitro. IE2 contains several sequence motifs that are common to t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1332

    authors： Yoo S,Guarino LA

    更新日期：1994-07-01 00:00:00

  • Activation of human immunodeficiency virus type 1 provirus in T-cells and macrophages is associated with induction of inducer-specific NF-kappa B binding proteins.

    abstract：:We have analyzed the limiting factors involved in the induction of human immunodeficiency virus type 1 (HIV-1) provirus expression by tumor necrosis factor-alpha (TNF-alpha), phorbol-12-myristate-13-acetate (PMA), and bryostatin-1 in T-cells (ACH-2) and monocytes (U1). We have demonstrated that, while there is a corre...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90295-z

    authors： Vlach J,Pitha PM

    更新日期：1992-03-01 00:00:00

  • Analysis of TYA protein regions necessary for formation of the Ty1 virus-like particle structure.

    abstract：:The yeast retrotransposon, Ty1, produces a macromolecular structure known as a virus-like particle (VLP) as an essential part of its replication cycle. The Ty1 Gag-like structural protein TYA, p1-440, alone is capable of directing assembly of the VLP. In order to determine the TYA sequences required for assembly, we h...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1454

    authors： Brookman JL,Stott AJ,Cheeseman PJ,Adamson CS,Holmes D,Cole J,Burns NR

    更新日期：1995-09-10 00:00:00

  • Differential dependence of the infectivity of HIV-1 group O isolates on the cellular protein cyclophilin A.

    abstract：:The cellular protein Cyclophilin A (Cyp A) is packaged into human immunodeficiency virus type 1 (HIV-1) particles through a specific interaction with the capsid domain of the Gag polyprotein. Inhibition of Cyp A incorporation by mutagenesis or cyclosporin treatment severely affects infectivity of all HIV-1 M subtypes ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1347

    authors： Wiegers K,Kräusslich HG

    更新日期：2002-03-15 00:00:00

  • Hexagonal organization of Moloney murine leukemia virus capsid proteins.

    abstract：:To help elucidate the mechanisms by which retrovirus structural proteins associate to form virus particles, we have examined membrane-bound assemblies of Moloney murine leukemia virus (M-MuLV) capsid (CA) proteins. Electron microscopy and image reconstruction techniques showed that CA dimers appear to function as orga...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1452

    authors： Mayo K,McDermott J,Barklis E

    更新日期：2002-06-20 00:00:00

  • The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine.

    abstract：:Segment 7 (M) of the cold-adapted live influenza A virus vaccine plays a primary role in the ability of this virus to interfere with the replication of wild-type influenza A viruses. This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influenza A/Ann Arbor/6/60 (H...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90011-y

    authors： Whitaker-Dowling P,Zvolenski R,Youngner JS

    更新日期：1991-01-01 00:00:00

  • In vivo analysis of the cell cycle dependent association of the bovine papillomavirus E2 protein and ChlR1.

    abstract：:It has been shown that the genomes of episomally maintained DNA viruses are tethered to host cell chromosomes during cell division, facilitating maintenance in dividing cells. The papillomavirus E2 protein serves this mechanism of viral genome persistence by simultaneously associating with chromatin and the viral geno...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.03.015

    authors： Feeney KM,Saade A,Okrasa K,Parish JL

    更新日期：2011-05-25 00:00:00

  • The host Pex19p plays a role in peroxisomal localization of tombusvirus replication proteins.

    abstract：:Replication of Tomato bushy stunt virus (TBSV) RNA takes place on the cytosolic membrane surface of peroxisomes in plants and in yeast, a model host. To identify the host proteins involved in assisting the peroxisomal localization of the tombusvirus p33 replication protein, we tested if p33 could bind directly to yeas...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.06.044

    authors： Pathak KB,Sasvari Z,Nagy PD

    更新日期：2008-09-30 00:00:00

  • The p33 auxiliary replicase protein of Cucumber necrosis virus targets peroxisomes and infection induces de novo peroxisome formation from the endoplasmic reticulum.

    abstract：:Tombusviruses replicate on pre-existing organelles such as peroxisomes or mitochondria, the membranes of which become extensively reorganized into multivesicular bodies (MVBs) during the infection process. Cucumber necrosis virus (CNV) has previously been shown to replicate in association with peroxisomes in yeast. We...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.12.035

    authors： Rochon D,Singh B,Reade R,Theilmann J,Ghoshal K,Alam SB,Maghodia A

    更新日期：2014-03-01 00:00:00

  • BST-2 mediated restriction of simian-human immunodeficiency virus.

    abstract：:Pathogenic simian-human immunodeficiency viruses (SHIV) contain HIV-1 Vpu and SIV Nef, both shown to counteract BST-2 (HM1.24; CD317; tetherin) inhibition of virus release in a species-specific manner. We show that human and pig-tailed BST-2 (ptBST-2) restrict SHIV. We found that sequential "humanization" of the trans...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.021

    authors： Ruiz A,Lau D,Mitchell RS,Hill MS,Schmitt K,Guatelli JC,Stephens EB

    更新日期：2010-10-25 00:00:00

  • Sequence analysis of the phosphoprotein (P) genes of human parainfluenza type 4A and 4B viruses and RNA editing at transcript of the P genes: the number of G residues added is imprecise.

    abstract：:We cloned and sequenced the cDNAs against genomic RNAs and mRNAs for phosphoproteins (Ps) of human parainfluenza virus types 4A (PIV-4A) and 4B (PIV-4B). The PIV-4A and -4B P genes were 1535 nucleotides including poly(A) tract and were found to have two small open reading frames, neither of which was apparently large ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90413-l

    authors： Kondo K,Bando H,Tsurudome M,Kawano M,Nishio M,Ito Y

    更新日期：1990-09-01 00:00:00

  • Alphavirus production is inhibited in neurofibromin 1-deficient cells through activated RAS signalling.

    abstract：:Virus-host interactions essential for alphavirus pathogenesis are poorly understood. To address this shortcoming, we coupled retrovirus insertional mutagenesis and a cell survival selection strategy to generate clonal cell lines broadly resistant to Sindbis virus (SINV) and other alphaviruses. Resistant cells had sign...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.03.025

    authors： Kolokoltsova OA,Domina AM,Kolokoltsov AA,Davey RA,Weaver SC,Watowich SJ

    更新日期：2008-07-20 00:00:00

  • Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus.

    abstract：:The N-terminal domains of the NS1 protein of influenza B virus (NS1B protein) and the NS1 protein of influenza A virus (NS1A protein) share one function: binding double-stranded RNA (dsRNA). Here we show that the N-terminal domain of the NS1B protein possesses an additional function that is not shared by its NS1A coun...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1663

    authors： Yuan W,Aramini JM,Montelione GT,Krug RM

    更新日期：2002-12-20 00:00:00

  • Isolation and genetic characterization of temperature-sensitive mutants that define five additional recombination groups in simian rotavirus SA11.

    abstract：:Nineteen independent temperature-sensitive (ts) mutants were isolated from SA11 following mutagenesis with proflavin or 5-azacytidine. Fourteen of the ts mutants fell into one or another of five mutant groups previously defined by recombination. Five of the ts mutants defined five recombination groups (F, G, H, I, and...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90100-9

    authors： Ramig RF

    更新日期：1983-10-30 00:00:00

  • Rice tungro bacilliform virus open reading frame 3 encodes a single 37-kDa coat protein.

    abstract：:Rice tungro bacilliform virus (RTBV) is a plant pararetrovirus and a member of the Caulimoviridae family and closely related to viruses in the Badnavirus genus. The coat protein of RTBV is part of the large polyprotein encoded by open reading frame 3 (ORF3). ORF3 of an RTBV isolate from Malaysia was sequenced (accessi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9519

    authors： Marmey P,Bothner B,Jacquot E,de Kochko A,Ong CA,Yot P,Siuzdak G,Beachy RN,Fauquet CM

    更新日期：1999-01-20 00:00:00

  • Pathogenic prion protein fragment (PrP106-126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages.

    abstract：:Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prp(sc), thought to be the causative agent of variant a Creutzfeldt-Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen in HIV-1 infection. In the pre...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.11.032

    authors： Bacot SM,Feldman GM,Yamada KM,Dhawan S

    更新日期：2015-02-01 00:00:00