Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus.

abstract：:Infectious bronchitis has remained one of the most difficult to control diseases in poultry since it was first described in 1931. Previous studies demonstrated that primary CD8(+) T lymphocytes collected at 10 days post-infection (p.i.) are important in controlling acute infection. To further investigate the role of m...

journal_title：Virology

authors： Pei J,Briles WE,Collisson EW

更新日期：2003-02-15 00:00:00

abstract：:Flaviviruses are single-stranded positive RNA viruses that replicate through double stranded RNA (dsRNA) intermediates. These dsRNA may be recognized as pathogen-associated molecular patterns by cellular receptors including membrane-bound Toll-like receptor 3 (TLR3) and cytosolic helicases RIG-I and MDA5. dsRNA stimul...

journal_title：Virology

authors： Baronti C,Sire J,de Lamballerie X,Quérat G

更新日期：2010-09-01 00:00:00

abstract：:The antigenic structure of the VP4 protein of human rotavirus (HRV) strains Wa and ST3 was studied by using a panel of Wa- and ST3-derived VP4-specific neutralizing monoclonal antibodies (NMAbs) and NMAb-resistant variants. The VP4-coding genes from three Wa and three ST3 variants were sequenced. For Wa VP4, one homot...

journal_title：Virology

authors： Padilla-Noriega L,Dunn SJ,López S,Greenberg HB,Arias CF

更新日期：1995-01-10 00:00:00

abstract：:Pseudorabies virus (PRV) China reference strain Ea is genetically closely related to newly emerged variants; however, there is limited information about PRV Ea. Here, we compared PRV Ea with new variant strains by growth kinetics, genome sequencing, and protein expression analysis. Growth analysis showed that strain E...

journal_title：Virology

authors： Wang X,Wu CX,Song XR,Chen HC,Liu ZF

更新日期：2017-06-01 00:00:00

abstract：:Chikungunya virus (CHIKV) represents a pandemic threat with no approved vaccine available. Recently, we described a novel vaccination strategy based on iDNA® infectious clone designed to launch a live-attenuated CHIKV vaccine from plasmid DNA in vitro or in vivo. As a proof of concept, we prepared iDNA plasmid pCHIKV-...

journal_title：Virology

authors： Hidajat R,Nickols B,Forrester N,Tretyakova I,Weaver S,Pushko P

更新日期：2016-03-01 00:00:00

abstract：:The nucleocapsids of many plant viruses are significantly more robust and protective of their RNA contents than those of enveloped animal viruses. In particular, the capsid protein (CP) of the plant virus Cowpea Chlorotic Mottle Virus (CCMV) is of special interest because it has been shown to spontaneously package, wi...

journal_title：Virology

authors： Azizgolshani O,Garmann RF,Cadena-Nava R,Knobler CM,Gelbart WM

更新日期：2013-06-20 00:00:00

abstract：:An open reading frame which encodes at least 90% of the adenovirus type 2 DNA polymerase gene was cloned behind the SP6 promoter and transcribed in vitro using the SP6 RNA polymerase. The resultant RNA was translated in a rabbit reticulocyte cell free system. In addition to the translation of a 120-kDa protein corresp...

journal_title：Virology

authors： Hassin D,Korn R,Horwitz MS

更新日期：1986-11-01 00:00:00

abstract：:Cauliflower mosaic virus (CaMV) strains CM1841 and W260 produced markedly different symptoms when inoculated onto turnips (Brassica campestris L. 'Just Right'). The CM1841 strain induced a mild degree of stunting of infected plants while strain W260 caused moderate to severe stunting. Although CM1841 was significantly...

journal_title：Virology

authors： Anderson EJ,Qui SG,Schoelz JE

更新日期：1991-04-01 00:00:00

abstract：:Extra MMTV proviruses in T-cell leukemias of GR and C57/BL10 mice contain alterations in their long terminal repeat (LTR) sequence. The four different leukemias studied contain different deletions, but common hallmarks were observed around the recombination sites. At the 5' end of the deletions we observed a common no...

journal_title：Virology

authors： Michalides R,Wagenaar E

更新日期：1986-10-15 00:00:00

abstract：:Coordinated expression of viral genes in primary infection is essential for successful infection of host cells. We examined the expression profiles of Kaposi's sarcoma-associated herpesvirus (KSHV) transcripts in productive primary infection of primary human umbilical vein endothelial cells by whole-genome reverse-tra...

journal_title：Virology

authors： Yoo SM,Zhou FC,Ye FC,Pan HY,Gao SJ

更新日期：2005-12-05 00:00:00

abstract：:Hepatitis C virus (HCV) core protein is a multifunctional protein interacting with cellular and viral proteins and promoters. A tetracycline-regulated system was used to generate a HepG2 Tet-Off cell line allowing regulated expression of a full-length (191 aa) and an N(c)-truncated core protein (160 aa). In this syste...

journal_title：Virology

authors： Erhardt A,Hassan M,Heintges T,Häussinger D

更新日期：2002-01-20 00:00:00

abstract：:MuSV349 is a TB-cell line which produces infectious MuSV with little or no MuLV detectable by the XC assay. The apparent restriction of MuLV replication in MuSV349 cells was investigated. A replication-competent helper virus, with protein composition nearly identical to that of Mo-MuLV was isolated from the viruses pr...

journal_title：Virology

authors： Yuen PH,Soong MM,Kissil MS,Wong PK

更新日期：1984-01-30 00:00:00

abstract：:The details of intracellular transport pathways for glycosylated proteins remain incompletely described. We previously described a mutant Rous sarcoma virus envelope glycoprotein (gp), mu 26, with an altered membrane-spanning domain that was targeted to lysosomes after traversing the trans-Golgi. This mutant protein w...

journal_title：Virology

authors： Johnston PB,Dong JY,Hunter E

更新日期：1995-01-10 00:00:00

abstract：:Adenovirus serotype 5 (Ad5) is a common cause of respiratory tract infection, and populations worldwide have high prevalence of anti-Ad5 antibodies, implying extensively prior infection. Ad5 infection potently activates the host innate defense and inflammation, but the molecular mechanisms are not completely clarified...

journal_title：Virology

authors： Li P,Feng F,Pan E,Fan X,Yang Q,Guan M,Chen L,Sun C

更新日期：2018-06-01 00:00:00

abstract：:Clones have been constructed containing full-length cDNA copies of PEBV RNA1 and RNA2, flanked by the CaMV 35 S RNA promoter and the nopaline synthase terminator. The clones are infectious when inoculated onto Nicotiana benthamiana plants. Both the viral RNAs and the virus particles were identified in infected plants....

journal_title：Virology

authors： MacFarlane SA,Gilmer D,Davies JW

更新日期：1992-04-01 00:00:00

abstract：:The 130-kDa bovine herpesvirus-1 (BHV-1) glycoprotein GVP 6 was found to cross-react immunologically with the herpes simplex glycoprotein gB. Antibodies in polyclonal serum against gB immunoprecipitated GVP 6 and its cleavage products from a lysate of BHV-1-infected cells. Conversely, polyclonal serum against GVP 6 pr...

journal_title：Virology

authors： Misra V,Nelson R,Smith M

更新日期：1988-10-01 00:00:00

abstract：:Epstein-Barr virus nuclear antigen 1 (EBNA 1) has been shown to be a sequence-specific DNA binding protein that is required for the replication of episomal elements carrying the viral origin of DNA replication, oriP, as well as for the activation of a specific transcriptional enhancer. We have constructed and analyzed...

journal_title：Virology

authors： Polvino-Bodnar M,Schaffer PA

更新日期：1992-04-01 00:00:00

abstract：:To be incorporated into progeny virions, the viral genome must be transported to the inner leaflet of the plasma membrane (PM) and accumulate there. Some viruses utilize lipid components to assemble at the PM. For example, simian virus 40 (SV40) targets the ganglioside GM1 and human immunodeficiency virus type 1 (HIV-...

journal_title：Virology

authors： Kakisaka M,Yamada K,Yamaji-Hasegawa A,Kobayashi T,Aida Y

更新日期：2016-09-01 00:00:00

abstract：:Powassan virus (POWV, Flaviviridae: Flavivirus) is the sole North American member of the tick-borne encephalitis complex and consists of two distinct lineages that are maintained in ecologically discrete enzootic transmission cycles. The underlying genetic mechanisms that lead to niche partitioning in arboviruses are ...

journal_title：Virology

authors： Brackney DE,Brown IK,Nofchissey RA,Fitzpatrick KA,Ebel GD

更新日期：2010-07-05 00:00:00

abstract：:The single-cell ELISPOT assay was used to determine the frequency and isotype commitment of virus-specific antibody-forming cells (AFC) at different anatomical locations following intranasal Sendai virus infection of C57BL/6 and 129/Sv mice. AFC responses in the mediastinal and cervical lymph nodes showed sharp increa...

journal_title：Virology

authors： Sangster M,Hyland L,Sealy R,Coleclough C

更新日期：1995-02-20 00:00:00

abstract：:Coinfection of tobacco plants with potato virus X (PVX) and any of several members of the potyvirus group causes a synergistic disease characterized by a dramatic increase in symptom severity correlated with a 3- to 10-fold increase in the accumulation of PVX in the first systemically infected leaves. We have recently...

journal_title：Virology

authors： Shi XM,Miller H,Verchot J,Carrington JC,Vance VB

更新日期：1997-04-28 00:00:00

abstract：:How the H7N9 avian influenza virus gained the distinct ability to infect humans is unclear. Pigs are an important host in influenza virus ecology because they are susceptible to infection with both avian and human influenza viruses and are often involved in interspecies transmission. Here, we passaged one avian isolat...

journal_title：Virology

authors： Xu L,Bao L,Deng W,Zhu H,Li F,Chen T,Lv Q,Yuan J,Xu Y,Li Y,Yao Y,Gu S,Yu P,Chen H,Qin C

更新日期：2014-03-01 00:00:00

abstract：:We previously showed that reduced infectivity of HIV with incompletely processed capsid-spacer protein 1 (CA-SP1) is rescued by cellular activation or increased expression of HSP90AB1, a member of the cytosolic heat shock protein 90 family. Here we show that HSP90AB1 is present in HIV virions and that HSP90AB1, but no...

journal_title：Virology

authors： Joshi P,Sloan B,Torbett BE,Stoddart CA

更新日期：2013-02-05 00:00:00

abstract：:Soluble RNA-dependent RNA polymerases from healthy and alfalfa mosaic virus (AMV)-infected leaves were purified more than 400-fold from the 100,000g supernatant of leaf homogenates, using ammonium sulfate precipitation, Sephadex G-100 filtration, and chromatography on DEAE Sephadex A25 and P11-phosphocellulose. The DE...

journal_title：Virology

authors： Chifflot S,Sommer P,Hartmann D,Stussi-Garaud C,Hirth L

更新日期：1980-01-15 00:00:00

abstract：:Herpes simplex virus mutant strains that fail to encode a functional ICP27 polypeptide show a reduction in their ability to replicate viral DNA compared to wild-type virus. To define the nature of this defect, we examined the formation of viral DNA replication structures in the nucleus of cells infected with these mut...

journal_title：Virology

authors： Curtin KD,Knipe DM

更新日期：1993-09-01 00:00:00

abstract：:Edible vaccines that can be made widely available and easily administered could bring great benefit to the worldwide battle against pandemic viral infections. They can be used not only for the vaccination of humans and domesticated animals, but also for wild herds and live stock which are otherwise difficult to vaccin...

journal_title：Virology

authors： Lei H,Xu Y,Chen J,Wei X,Lam DM

更新日期：2010-11-25 00:00:00

abstract：:A new set of lambdoid phages (mEp) classified into different immunity groups was previously described. Phages mEp213, mEp237, and mEp410 were unable to grow in mEp167 lysogenic cells, presumably due to an exclusion mechanism expressed constitutively by the mEp167 repressed prophage. In this work, to analyze the exclus...

journal_title：Virology

authors： Uc-Mass A,Loeza EJ,de la Garza M,Guarneros G,Hernández-Sánchez J,Kameyama L

更新日期：2004-11-24 00:00:00

abstract：:Adenoviruses with deletion of E1b have been used in clinical trials to treat cancers that are resistant to conventional therapies. The efficacy of viral replication within cancer cells determines the results of oncolytic therapy, which remains poorly understood and requires further improvement. In this report, we show...

journal_title：Virology

authors： Rodriguez-Rocha H,Gomez-Gutierrez JG,Garcia-Garcia A,Rao XM,Chen L,McMasters KM,Zhou HS

更新日期：2011-07-20 00:00:00

abstract：:A plasmid-based transfection system capable of generating infectious porcine circovirus type 2 (PCV2) was established. This system was then used in mutagenesis studies to investigate the involvement of a "conserved" nonanucleotide (which constitutes a portion of the loop sequence) located at the origin of DNA replicat...

journal_title：Virology

authors： Cheung AK

更新日期：2004-06-20 00:00:00

abstract：:This study attempts to isolate and characterize West Nile virus-binding molecules on the plasma membrane of Vero and murine neuroblastoma cells that is responsible for virus entry. Pretreatment of Vero cells with proteases, glycosidases (endoglycosidase H, alpha-mannosidase), and sodium periodate strongly inhibited We...

journal_title：Virology

authors： Chu JJ,Ng ML

更新日期：2003-08-01 00:00:00