Immunoprotection against influenza H5N1 virus by oral administration of enteric-coated recombinant Lactococcus lactis mini-capsules.

abstract：:When electrophoresed in 0.7% agarose gels, populations of reovirus particles can be resolved into 13 well-defined bands that possess from 0 to 12 projection/spike-associated trimers of protein sigma 1. This state of affairs is not an artifact of purification, of the techniques used to demonstrate it, of aggregation, o...

journal_title：Virology

authors： Larson SM,Antczak JB,Joklik WK

更新日期：1994-06-01 00:00:00

abstract：:To accomplish their viral life cycle, lentiviruses such as HIV highjack host proteins, the so-called cellular co-factors of replication. Lens Epithelium-derived Growth factor (LEDGF/p75), a transcriptional co-activator, is a co-factor of HIV-integrase (IN) and is required for the tethering and correct integration of t...

journal_title：Virology

authors： Christ F,Debyser Z

更新日期：2013-01-05 00:00:00

abstract：:Cardioviruses cause diseases in many animals including, in rare cases, humans. Although they share common features with all picornaviruses, cardioviruses have unique properties that distinguish them from other family members, including enteroviruses. One feature shared by all picornaviruses is the covalent attachment ...

journal_title：Virology

authors： Maciejewski S,Ullmer W,Semler BL

更新日期：2018-03-01 00:00:00

abstract：:Gene transfer into human hematopoietic stem cells using Ad5 is inefficient due to lack of the primary receptor CAR and the secondary receptors alphavbeta3 integrin and alphavbeta5 integrin, and due to the high seroprevalence of Ad5 antibodies in most adults, resulting in diminished gene transduction. In the present st...

journal_title：Virology

authors： Mei YF,Segerman A,Lindman K,Hörnsten P,Wahlin A,Wadell G

更新日期：2004-10-25 00:00:00

abstract：:Although it is known that Ad5-specific neutralizing antibodies (NAbs) against three major viral capsid components (hexon, penton and fiber) are generated, differences in the frequency and nature of these pre-existing NAbs remain unclear. The results emphasized the contribution of anti-fiber antibodies to Ad5 neutraliz...

journal_title：Virology

authors： Yu B,Dong J,Wang C,Zhan Y,Zhang H,Wu J,Kong W,Yu X

更新日期：2013-03-15 00:00:00

abstract：:Mouse hepatitis virus strain A59 (MHV-A59) encodes within the 22-kb gene 1 a large polyprotein containing three proteinase domains with proven or predicted cysteine catalytic residues. E64d, a specific, irreversible inhibitor of cysteine (thiol) proteinases, inhibits the processing of the gene 1 polyprotein. Specifica...

journal_title：Virology

authors： Kim JC,Spence RA,Currier PF,Lu X,Denison MR

更新日期：1995-04-01 00:00:00

abstract：:The complete nucleotide sequence of apple stem grooving virus (ASGV) genome has been determined. The genome is 6496 nucleotides in length excluding a 3'-terminal poly(A) tail and contains two overlapping open reading frames (ORFs). ORF1 begins at nucleotide position 37 and is terminated at position 6341, encoding a pr...

journal_title：Virology

authors： Yoshikawa N,Sasaki E,Kato M,Takahashi T

更新日期：1992-11-01 00:00:00

abstract：:Primary strains of human immunodeficiency virus type 1 (HIV-1) are known to adapt to replication in cell lines in vitro by becoming sensitive to soluble CD4 (sCD4) and neutralizing antibodies (NAb). T-cell lines favor isolation of variants that use CXCR4 as a co-receptor, while primary isolates predominantly use CCR5....

journal_title：Virology

authors： Pugach P,Kuhmann SE,Taylor J,Marozsan AJ,Snyder A,Ketas T,Wolinsky SM,Korber BT,Moore JP

更新日期：2004-03-30 00:00:00

abstract：:Ten mutations were introduced into the JC virus (JCV) T antigen within a region corresponding to the SV40 T-antigen DNA binding domain (SV40 amino acids 131 to 220); nine of these increased homology between the two proteins in sequences critical for SV40 T antigen DNA binding. All mutant JCV T antigens bound to JCV an...

journal_title：Virology

authors： Tavis JE,Frisque RJ

更新日期：1991-07-01 00:00:00

abstract：:Nucleotide sequence analysis has shown previously that the genomic-length mRNA (mRNA1) of the coronavirus infectious bronchitis virus (IBV) contains two large open reading frames (ORFs), 1a and 1b, with the potential to encode polyproteins of approximately 441 and 300 kDa, respectively. We have characterized the speci...

journal_title：Virology

authors： Liu DX,Tibbles KW,Cavanagh D,Brown TD,Brierley I

更新日期：1995-04-01 00:00:00

abstract：:The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein Vif that induces APOBEC3 degradation. Here we compared two common po...

journal_title：Virology

authors： Mohammadzadeh N,Follack TB,Love RP,Stewart K,Sanche S,Chelico L

更新日期：2019-01-15 00:00:00

abstract：:CD8+ T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8+ T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and examined surface proteins, cytoki...

journal_title：Virology

authors： Liu M,Barton ES,Jennings RN,Oldenburg DG,Whirry JM,White DW,Grayson JM

更新日期：2017-09-01 00:00:00

abstract：:Sera from 215 non-drug-injecting Toba and Mataco-Mataguayo pure Indians belonging to four communities in northern Argentina were examined using assays that allow differentiation between reactivities due to type-specific antigens of the human T-cell leukemia/lymphoma virus (HTLV). Three of these populations have very l...

journal_title：Virology

authors： Ferrer JF,Del Pino N,Esteban E,Sherman MP,Dube S,Dube DK,Basombrio MA,Pimentel E,Segovia A,Quirulas S

更新日期：1993-12-01 00:00:00

abstract：:Economic loss due to viral endothelial cell necrosis of eel (VECNE) of Anguilla japonica is a serious problem for the cultured Japanese eel market. However, the viral genome responsible for VECNE is unknown. We recently developed a rapid determination system for viral nucleic acid sequences (RDV) to determine viral ge...

journal_title：Virology

authors： Mizutani T,Sayama Y,Nakanishi A,Ochiai H,Sakai K,Wakabayashi K,Tanaka N,Miura E,Oba M,Kurane I,Saijo M,Morikawa S,Ono S

更新日期：2011-03-30 00:00:00

abstract：:We previously analyzed hybrids of Cucumber mosaic virus (CMV) and Tomato aspermy virus (TAV) that contained CMV RNA2 with the 3'-terminal sequence from TAV RNA2. In this article, we scrutinized the RNA3 molecules in these hybrid viruses by Northern hybridization and RT-PCR and found some recombinant CMV RNA3 molecules...

journal_title：Virology

authors： Suzuki M,Hibi T,Masuta C

更新日期：2003-02-01 00:00:00

abstract：:Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation. Here, we provide evidence that an arginine/lysine cluster located at the transmembrane-cytoplasm interface of gD critically c...

journal_title：Virology

authors： Carmichael JC,Starkey J,Zhang D,Sarfo A,Chadha P,Wills JW,Han J

更新日期：2019-01-15 00:00:00

abstract：:Bipartite geminiviruses are small, plant-infecting viruses with genomes composed of circular, single-stranded DNA molecules, designated A and B. Although they are closely related genetically, individual bipartite geminiviruses frequently exhibit host-specific adaptation. Two such viruses are bean golden mosaic virus (...

journal_title：Virology

authors： Petty IT,Carter SC,Morra MR,Jeffrey JL,Olivey HE

更新日期：2000-11-25 00:00:00

abstract：:Mouse LTK- cells (H-2k) were transfected with a series of recombinant plasmids consisting of the herpes simplex virus type 1 thymidine kinase (TK) gene linked to fragments of SV40 DNA coding for portions of SV40 T antigen in pBR322, and TK+ transformants (LTK+) were selected in HAT medium. The TK+ transformants were a...

journal_title：Virology

authors： Tevethia SS,Tevethia MJ,Lewis AJ,Reddy VB,Weissman SM

更新日期：1983-07-30 00:00:00

abstract：:The assembly of the tegument of herpes simplex virus type 1 (HSV-1) is a complex process that involves a number of events at various sites within virus-infected cells. Our studies focused on determining whether tegument proteins, VP1/2 and UL37, are added to capsids located within the nucleus. Capsids were isolated fr...

journal_title：Virology

authors： Bucks MA,O'Regan KJ,Murphy MA,Wills JW,Courtney RJ

更新日期：2007-05-10 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection can be inhibited by small molecules that target the CCR5 coreceptor. Here, we describe some properties of clonal viruses resistant to one such inhibitor, SCH-D, using both chimeric, infectious molecular clones and Env-pseudotypes. Studies using combinations of CCR5...

journal_title：Virology

authors： Pugach P,Marozsan AJ,Ketas TJ,Landes EL,Moore JP,Kuhmann SE

更新日期：2007-04-25 00:00:00

abstract：:At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for...

journal_title：Virology

authors： Rasmussen L,Mullenax J,Nelson M,Merigan TC

更新日期：1985-08-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is nonenveloped and has a single-stranded positive-sense RNA genome. CVB3 induces myocarditis and ultimately dilated cardiomyopathy. Although there are mounting evidences of an interaction between CVB3 particles and the cellular receptors, coxsackievirus and adenovirus receptor (CAR) and decay...

journal_title：Virology

authors： Chung SK,Kim JY,Kim IB,Park SI,Paek KH,Nam JH

更新日期：2005-03-01 00:00:00

abstract：:Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cell...

journal_title：Virology

authors： Desport M,Tenaya IW,McLachlan A,McNab TJ,Rachmat J,Hartaningsih N,Wilcox GE

更新日期：2009-10-25 00:00:00

abstract：:HCV genotype is a major determinant of clinical outcome, and GT1b HCV infection is the most difficult to treat and also the predominant genotype in East Asia and Europe. We developed 1b/JFH-1 inter-genotypic recombinants containing the structural genes (Core, E1, E2), p7 and the 1stTMD of NS2 directly from GT1b clinic...

journal_title：Virology

authors： Lu J,Tao W,Li R,Xiang Y,Zhang N,Xiang X,Xie Q,Zhong J

更新日期：2013-08-15 00:00:00

abstract：:Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein characterized by its ability to depurinate the sarcin/ricin (S/R) loop of the large rRNA of prokaryotic and eukaryotic ribosomes. Here, a series of PAP mutants were used to examine the relationship between depurination of the S/R loop and inhibition o...

journal_title：Virology

authors： Hudak KA,Hammell AB,Yasenchak J,Tumer NE,Dinman JD

更新日期：2001-01-05 00:00:00

abstract：:To elucidate the virulence factors of equine herpesvirus-1 (EHV-1), we compared the genomic architecture of the HH1 strain, a Japanese isolate of EHV-1, with that of its four descendant strains obtained by serial passage in bovine kidney (BK) cells, i.e. BK77, BK161, BK271, and BK343. In preliminary studies high-passa...

journal_title：Virology

authors： Kirisawa R,Ui S,Takahashi A,Kawakami Y,Iwai H

更新日期：1994-05-01 00:00:00

abstract：:Sequence variants of the Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) have been reported in association with EBV-linked malignancies but little is known about their effects on signalling pathways and phenotype. We have examined the ability of the nasopharyngeal carcinoma (NPC)-derived variant, CAO...

journal_title：Virology

authors： Blake SM,Eliopoulos AG,Dawson CW,Young LS

更新日期：2001-04-10 00:00:00

abstract：:Lipid binding properties which are dependent on exposure to acid pH are an important mechanism for the cellular entry pathway for some enveloped viruses and for other macromolecules. Cell-to-cell fusion can be used to demonstrate this function. La Crosse virus, a member of the family Bunyaviridae, fused BHK-21 cells f...

journal_title：Virology

authors： Gonzalez-Scarano F,Pobjecky N,Nathanson N

更新日期：1984-01-15 00:00:00

abstract：:The interferon sensitivity of the expression of an influenza-virus hemagglutinin (HA) gene cloned into the thymidine kinase (TK) gene of vaccinia virus was studied in chick embryo fibroblasts (CEF) and Madin-Darby bovine kidney (MDBK) cells. In CEF, the expression of the HA gene is inhibited by pretreatment of cells w...

journal_title：Virology

authors： Degen HJ,Blum D,Grün J,Jungwirth C

更新日期：1992-05-01 00:00:00

abstract：:We have shown that the binding of simian immunodeficiency virus (SIV) to Jurkat T cells expressing CD4 receptor strongly induces mitogen-activated protein (MAP) kinase kinase (MEK) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) and only weakly induces p38 MAP kinase and c-Jun N-terminal kinase (JNK). Simi...

journal_title：Virology

authors： Popik W,Pitha PM

更新日期：1998-12-05 00:00:00