Adenoviruses induce autophagy to promote virus replication and oncolysis.

abstract：:Equine influenza is caused by two serotypes of type A influenza virus, EIV-A1 and EIV-A2. The complete nucleotide sequence of the neuraminidase (NA) genes of both the A1 (N7 subtype) and A2 (N8 subtype) serotype has been determined following cloning of full-length viral NA cDNAs into pBR322. Analysis of the deduced am...

journal_title：Virology

authors： Dale B,Brown R,Miller J,White RT,Air GM,Cordell B

更新日期：1986-12-01 00:00:00

abstract：:This paper reports the molecular cloning of a rearranged c-myc region from the FT-1 cell line, which was derived from a spontaneous feline T-cell leukemia carrying the feline leukemia virus (FeLV). An abnormal c-myc EcoRI fragment of about 18 kilobases, detected by Southern blotting, was molecularly cloned from the DN...

journal_title：Virology

authors： Miura T,Shibuya M,Tsujimoto H,Fukasawa M,Hayami M

更新日期：1989-04-01 00:00:00

abstract：:We investigated whether culture conditions could affect the RANTES antiviral effect on human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages. Monocyte-derived macrophages (MDM) were obtained either as (1) the adherent cells of 5-day cultures of blood mononuclear cells (PBMC), followed by 2 days ...

journal_title：Virology

authors： Amzazi S,Ylisastigui L,Bakri Y,Rabehi L,Gattegno L,Parmentier M,Gluckman JC,Benjouad A

更新日期：1998-12-05 00:00:00

abstract：:Of five globally important VP7 (G) serotypes (G1-4 and 9) of group A rotaviruses (the single most important etiologic agents of infantile diarrhea worldwide), G9 continues to attract considerable attention because of its unique natural history. Serotype G9 rotavirus was isolated from a child with diarrhea first in the...

journal_title：Virology

authors： Hoshino Y,Honma S,Jones RW,Ross J,Santos N,Gentsch JR,Kapikian AZ,Hesse RA

更新日期：2005-02-05 00:00:00

abstract：:In an attempt to develop an in vitro human cytomegalovirus (HCMV) latency model system, the growth characteristics of HCMV in a human thyroid papillary carcinoma cell line (TPC-1) were examined. When TPC-1 cultures preheated at 40.5 degrees for 48 hr were infected with HCMV and incubated at a supraoptimal temperature ...

journal_title：Virology

authors： Tanaka J,Ogura T,Sato H,Hatano M

更新日期：1987-11-01 00:00:00

abstract：:We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV resistance, compared to either single mutant. Unexpectedly, K101E+G190S also repli...

journal_title：Virology

authors： Wang J,Liang H,Bacheler L,Wu H,Deriziotis K,Demeter LM,Dykes C

更新日期：2010-07-05 00:00:00

abstract：:Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus that, following primary infection (varicella), establishes latency in sensory, autonomic, sympathetic and parasympathetic neurons, where it remains until reactivation (zoster). VZV-specific cell-mediated immune responses maintain VZV latency; thus, immunos...

journal_title：Virology

authors： Como CN,Pearce CM,Cohrs RJ,Baird NL

更新日期：2018-09-01 00:00:00

abstract：:This report describes induction of HIV-1 resistance and synthesis of resistance factors in immortal CD4-positive T lymphocytes. SupT1 cells were infected by NL4-3 attenuated by a defect in the vif gene through coculture with infected primary lymphocytes. Cell lines from this infection, termed R1, expressed CD4 and CXC...

journal_title：Virology

authors： Simm M,Miller LS,Durkin HG,Allen M,Chao W,Lesner A,Potash MJ,Volsky DJ

更新日期：2002-03-01 00:00:00

abstract：:To further our understanding of structure-function relationships within the multifunctional adenovirus DNA binding protein (DBP) a more diverse collection of mutants is necessary. DBP-expressing cell lines (gmDBP) were previously constructed that complemented DBP-negative mutants for viral growth. However, they did no...

journal_title：Virology

authors： Brough DE,Cleghon V,Klessig DF

更新日期：1992-10-01 00:00:00

abstract：:Equine herpesvirus 1 (EHV-1) recombinants that carry either a deletion of glycoprotein M (gM) or express mutant forms of gM were constructed. The recombinants were derived from strain Kentucky A (KyA), which also lacks genes encoding gE and gI. Plaques on RK13 cells induced by the gM-negative KyA were reduced in size ...

journal_title：Virology

authors： Seyboldt C,Granzow H,Osterrieder N

更新日期：2000-12-20 00:00:00

abstract：:Plasmid p12929 was shown to integrate into the chromosome of Corynebacterium glutamicum RM3 and BL15. The minimal integrating fragment was subsequently defined. The arms flanking the integrated plasmid (attL and attR) were identified, allowing for the determination of the attP and the attB attachment sites. The attB s...

journal_title：Virology

authors： Moreau S,Le Marrec C,Blanco C,Trautwetter A

更新日期：1999-03-01 00:00:00

abstract：:An antiserum was raised against a synthetic peptide corresponding to the 18 C-terminal amino acids of a putative 16K protein encoded by the 3'-terminal open reading frame of tobacco rattle virus (TRV) RNA-1. This antiserum was used to demonstrate expression of the 16K cistron in vivo. TRV-infected tobacco protoplasts ...

journal_title：Virology

authors： Angenent GC,Verbeek HB,Bol JF

更新日期：1989-04-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) isolated from two independently established lines of persistently infected mouse L cells expressed an altered phenotype of RNA synthesis at 37 degrees, the temperature at which the persistently infected cultures were maintained (T.K. Frey and J.S. Youngner, 1982, J. Virol. 44, 167-174)...

journal_title：Virology

authors： Frey TK,Youngner JS

更新日期：1984-07-15 00:00:00

abstract：:The Hepatitis B virus precore protein is processed in the endoplasmic reticulum (ER) into secreted hepatitis B e antigen (HBeAg), which acts as an immune tolerogen to establish chronic infection. Downregulation of secreted HBeAg should improve clinical outcome, as patients who effectively respond to current treatments...

journal_title：Virology

authors： Walsh R,Nuttall S,Revill P,Colledge D,Cabuang L,Soppe S,Dolezal O,Griffiths K,Bartholomeusz A,Locarnini S

更新日期：2011-03-01 00:00:00

abstract：:The genome of Lelystad virus (LV), a positive-strand RNA virus, is 15 kb in length and contains 8 open reading frames (ORFs) that encode putative viral proteins. ORFs 2 to 7 were cloned in plasmids downstream of the Sp6 RNA polymerase promoter, and the translation of transcripts generated in vitro yielded proteins tha...

journal_title：Virology

authors： Meulenberg JJ,Petersen-den Besten A,De Kluyver EP,Moormann RJ,Schaaper WM,Wensvoort G

更新日期：1995-01-10 00:00:00

abstract：:Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR beta x delta-/-) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of...

journal_title：Virology

authors： Szomolanyi-Tsuda E,Brien JD,Dorgan JE,Garcea RL,Woodland RT,Welsh RM

更新日期：2001-02-15 00:00:00

abstract：:An essentially complete DNA copy of the ambisense S RNA species of Punta Toro (PT) phlebovirus (T. Ihara, H. Akashi, and D.H.L. Bishop, 1984, Virology 136, 293-306) has been inserted in either orientation into Autographa californica nuclear polyhedrosis baculovirus (AcNPV) in lieu of the 5' coding region of the AcNPV ...

journal_title：Virology

authors： Overton HA,Ihara T,Bishop DH

更新日期：1987-04-01 00:00:00

abstract：:Binding of a specific peptide(s) from a viral protein to major histocompatibility complex (MHC) class I molecules is a critical step in the activation of CD8(+) cytotoxic T lymphocytes (CTLs). Once activated, CTLs can cause lethal disease in an infected host, for example, by killing virus-containing ependymal and vent...

journal_title：Virology

authors： Oldstone MB,von Herrath M,Lewicki H,Hudrisier D,Whitton JL,Gairin JE

更新日期：1999-04-10 00:00:00

abstract：:At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for...

journal_title：Virology

authors： Rasmussen L,Mullenax J,Nelson M,Merigan TC

更新日期：1985-08-01 00:00:00

abstract：:To study the process of membrane fusion in Morbilliviruses, the fusion (F) glycoproteins of Peste des petits ruminants virus (PPRV) and Rinderpest virus (RPV) were expressed transiently in mammalian cells. The recombinant F proteins were found to be localized at the surface of transfected cells. The fusion activity, a...

journal_title：Virology

authors： Seth S,Shaila MS

更新日期：2001-10-10 00:00:00

abstract：:The rep gene of the defective human parvovirus, adeno-associated virus, (AAV) mediates several trans-acting functions important to virus replication, transcription, and gene expression. At least four overlapping polypeptides are expressed from the rep gene. We have constructed a prokaryotic vector which expressed in E...

journal_title：Virology

authors： Trempe JP,Mendelson E,Carter BJ

更新日期：1987-11-01 00:00:00

abstract：:Expression of foreign peptides on the surface of cowpea mosaic virus particles leads to the creation of chimaeras with a variety of phenotypes and yields. Two factors were shown to be particularly significant in determining the properties of a given chimaera: the length of the inserted sequence and its isoelectric poi...

journal_title：Virology

authors： Porta C,Spall VE,Findlay KC,Gergerich RC,Farrance CE,Lomonossoff GP

更新日期：2003-05-25 00:00:00

abstract：:The 5'-terminal noncoding region sequences were determined for the genome RNAs of seven strains of St. Louis encephalitis virus (SLEV) and one strain of West Nile virus (WNV) using a single synthetic cDNA primer complementary to the 5'-terminus of the coding region of a strain of WNV RNA. The 5'-terminal sequences obt...

journal_title：Virology

authors： Brinton MA,Dispoto JH

更新日期：1988-02-01 00:00:00

abstract：:In order to study the effect of nef gene expression on viral replication in monocytic cells, we established monocytic (U937 and THP-1) cell transfectants constitutively expressing the human immunodeficiency virus type 1 nef gene. We constructed a plasmid expressing the nef gene derived from an infectious clone, NL432,...

journal_title：Virology

authors： Tsunetsugu-Yokota Y,Matsuda S,Maekawa M,Saito T,Takemori T,Takebe Y

更新日期：1992-12-01 00:00:00

abstract：:Adeno-associated virus (AAV-2) replicates to high titers when host cells are coinfected with a helper virus. Here we analyzed the coinfection of AAV-2 and mouse adenovirus (MAV-1) in murine fibroblasts. We observed that AAV-2/MAV-1 coinfected NIH 3T3 cells produced approximately 10-40-fold less AAV-2 DNAse resistant p...

journal_title：Virology

authors： Bhrigu V,Trempe JP

更新日期：2009-07-20 00:00:00

abstract：:Using the complete genome sequences of 19 coronavirus genomes, we analyzed the codon usage bias, dinucleotide relative abundance and cytosine deamination in coronavirus genomes. Of the eight codons that contain CpG, six were markedly suppressed. The mean NNU/NNC ratio of the six amino acids using either NNC or NNU as ...

journal_title：Virology

authors： Woo PC,Wong BH,Huang Y,Lau SK,Yuen KY

更新日期：2007-12-20 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, has caused significant damage to the Asian and American pork industries. Coronavirus 3C-like protease (3CL(pro)), which is involved in the processing of viral polyproteins for viral replication, is an appealing antiviral drug target. Here,...

journal_title：Virology

authors： Ye G,Deng F,Shen Z,Luo R,Zhao L,Xiao S,Fu ZF,Peng G

更新日期：2016-07-01 00:00:00

abstract：:Methods currently used for HIV-1 viral load measurements are very sensitive, but cannot distinguish between infectious and noninfectious particles. Here we describe the development of a novel, sensitive, and highly reproducible method that allows rapid isolation and quantification of infectious particles from patient ...

journal_title：Virology

authors： Rusert P,Fischer M,Joos B,Leemann C,Kuster H,Flepp M,Bonhoeffer S,Günthard HF,Trkola A

更新日期：2004-08-15 00:00:00

abstract：:Essential host cofactors in retrovirus replication bind cis-acting sequences in the 5'untranslated region (UTR). Although host RBPs are crucial to all aspects of virus biology, elucidating their roles in replication remains a challenge to the field. Here RNA affinity-coupled-proteomics generated a comprehensive, unbia...

journal_title：Virology

authors： Stake M,Singh D,Singh G,Marcela Hernandez J,Kaddis Maldonado R,Parent LJ,Boris-Lawrie K

更新日期：2015-12-01 00:00:00

abstract：:Nipah virus (NiV) causes severe encephalitis in humans, with high mortality. NiV nonstructural C protein (NiV-C) is essential for its pathogenicity, but its functions are unclear. In this study, we focused on NiV-C trafficking in cells and found that it localizes predominantly in the cytoplasm but partly in the nucleu...

journal_title：Virology

authors： Horie R,Yoneda M,Uchida S,Sato H,Kai C

更新日期：2016-10-01 00:00:00