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Homogeneity of Powassan virus populations in naturally infected Ixodes scapularis.

Abstract：

:Powassan virus (POWV, Flaviviridae: Flavivirus) is the sole North American member of the tick-borne encephalitis complex and consists of two distinct lineages that are maintained in ecologically discrete enzootic transmission cycles. The underlying genetic mechanisms that lead to niche partitioning in arboviruses are poorly understood. Therefore, intra- and interhost genetic diversity was analyzed to determine if POWV exists as a quasispecies in nature and quantify selective pressures within and between hosts. In contrast to previous reports for West Nile virus (WNV), significant intrahost genetic diversity was not observed. However, pN (0.238) and d(N)/d(S) ratios (0.092) for interhost diversity were similar to those of WNV. Combined, these data suggest that purifying selection and/or population bottlenecks constrain quasispecies diversity within ticks. These same selective and stochastic mechanisms appear to drive minor sequence changes between ticks. Moreover, Powassan virus populations seem not to be structured as quasispecies in naturally infected adult deer ticks.

journal_name

Virology

journal_title

Virology

authors

Brackney DE,Brown IK,Nofchissey RA,Fitzpatrick KA,Ebel GD

doi

10.1016/j.virol.2010.03.035

subject

Has Abstract

pub_date

2010-07-05 00:00:00

pages

366-71

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(10)00218-7

journal_volume

402

pub_type

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