Treatment with PTEN-Long protein inhibits hepatitis C virus replication.

Abstract:

:Hepatitis C virus (HCV) infection is a confirmed risk factor for hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) possesses tumor suppression function that is frequently defective in HCC tumors. PTEN-Long, a translation isoform of PTEN, functions in a cell non-autonomous manner. In this study, we demonstrated that intracellular overexpression of PTEN-Long inhibits HCV replication. More importantly, we showed that treatment with extracellular PTEN-Long protein inhibits HCV replication in a dose-dependent manner. Furthermore, we showed that PTEN-Long interacts with HCV core protein and this interaction is required for HCV replication inhibition by PTEN-Long. In summary, we demonstrated, for the first time, that PTEN-Long protein, an isoform of the canonical PTEN and in the form of extracellular protein treatment, inhibits HCV replication. Our study offers an opportunity for developing additional anti-HCV agents.

journal_name

Virology

journal_title

Virology

authors

Wu Q,Li Z,Liu Q

doi

10.1016/j.virol.2017.08.002

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1-8

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(17)30256-8

journal_volume

511

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2.

    abstract::Human papillomavirus type 16 (HPV-16) E2 protein negatively regulates transcription of the E6 and E7 genes. This study was done to test the hypothesis that methylation of the HPV 16 long control region (LCR) is overrepresented among cervical cancer (CaCx) cases compared to cytologically normal controls harboring intac...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2006.06.018

    authors: Bhattacharjee B,Sengupta S

    更新日期:2006-10-25 00:00:00

  • Protein composition of the vaccinia virus mature virion.

    abstract::The protein content of vaccinia virus mature virions, purified by rate zonal and isopycnic centrifugations and solubilized by SDS or a solution of urea and thiourea, was determined by the accurate mass and time tag technology which uses both tandem mass spectrometry and Fourier transform-ion cyclotron resonance mass s...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2006.08.025

    authors: Resch W,Hixson KK,Moore RJ,Lipton MS,Moss B

    更新日期:2007-02-05 00:00:00

  • Ross River virus envelope glycans contribute to disease through activation of the host complement system.

    abstract::Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis. As MBL binds to carbohydrates, we hypothesized that N-linked glycans on the RRV ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2017.12.022

    authors: Gunn BM,Jones JE,Shabman RS,Whitmore AC,Sarkar S,Blevins LK,Morrison TE,Heise MT

    更新日期:2018-02-01 00:00:00

  • Analysis of the vif gene of feline immunodeficiency virus.

    abstract::We have examined FIV vif function in the context of molecular clone pF34 (GenBank Accession No. M25729). Rabbit antisera directed against the translation product of the vif gene identified a 29-kDa protein in tissue culture cells infected with FIV-pF34; this protein was not present in cultures of uninfected cells. Thu...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1994.1609

    authors: Shacklett BL,Luciw PA

    更新日期:1994-11-01 00:00:00

  • Autographa californica nuclear polyhedrosis virus: subcellular localization and protein trafficking of BV/ODV-E26 to intranuclear membranes and viral envelopes.

    abstract::The Autographa californica nuclear polyhedrosis virus da26 gene codes for an envelope protein of both budded virus (BV) and occlusion derived virus (ODV). Western blot and temporal analysis of infected cell extracts detected a protein of 26 kDa by 4 h postinfection (p.i.). The amount of protein increased by 16 h p.i. ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1997.8903

    authors: Beniya H,Braunagel SC,Summers MD

    更新日期:1998-01-05 00:00:00

  • The flavivirus-conserved penta-nucleotide in the 3' stem-loop of the West Nile virus genome requires a specific sequence and structure for RNA synthesis, but not for viral translation.

    abstract::A reporting replicon of West Nile virus (WN) was used to distinguish between the function of the 3' untranslated region (UTR) in viral translation and RNA replication. Deletions of various regions of the 3' UTR of the replicon did not significantly affect viral translation, but abolished RNA replication. A systematic ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2004.07.022

    authors: Tilgner M,Deas TS,Shi PY

    更新日期:2005-01-20 00:00:00

  • Properties of a new virus belonging to nodaviridae found in larval striped jack (Pseudocaranx dentex) with nervous necrosis.

    abstract::Spherical virus particles were purified from larval striped jack (Pseudocaranx dentex) with nervous necrosis. The virus consists of nonenveloped particles, about 25 nm in diameter, and contains two single-stranded, positive-sense RNA molecules with molecular weights of 1.01 x 10(6)Da (RNA 1) and 0.49 x 10(6)Da (RNA 2)...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(92)90329-n

    authors: Mori K,Nakai T,Muroga K,Arimoto M,Mushiake K,Furusawa I

    更新日期:1992-03-01 00:00:00

  • RNA-binding proteins of coronavirus MHV: detection of monomeric and multimeric N protein with an RNA overlay-protein blot assay.

    abstract::RNA-binding proteins of coronavirus MHV-A59 were identified using an RNA overlay-protein blot assay (ROPBA). The major viral RNA-binding protein in virions and infected cells was the phosphorylated nucleocapsid protein N (50K). A new 140K virus structural protein was identified as a minor RNA-binding protein both in v...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(86)90305-3

    authors: Robbins SG,Frana MF,McGowan JJ,Boyle JF,Holmes KV

    更新日期:1986-04-30 00:00:00

  • Multiple genes contribute to the virulent phenotype observed in ferrets of an H5N1 influenza virus isolated from Thailand in 2004.

    abstract::Human infections with highly pathogenic H5N1 avian influenza viruses continue to occur in many parts of the world and pose a considerable public health threat. With the use of animal models, the identification of virulence determinants has been instrumental in improving our understanding of how these viruses cause sev...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2011.02.005

    authors: Maines TR,Chen LM,Belser JA,Van Hoeven N,Smith E,Donis RO,Tumpey TM,Katz JM

    更新日期:2011-05-10 00:00:00

  • One hundred years of poliovirus pathogenesis.

    abstract::Poliovirus was first isolated nearly 100 years ago in a landmark experiment that established the viral etiology of poliomyelitis. This discovery stimulated investigation of the pathogenesis of poliomyelitis in many laboratories. Nearly 50 years later, when two effective poliovirus vaccines were developed, the impetus ...

    journal_title:Virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.virol.2005.09.015

    authors: Racaniello VR

    更新日期:2006-01-05 00:00:00

  • Natural variants of human adenovirus type 3 provide evidence for relative genome stability across time and geographic space.

    abstract::Human adenovirus type 3 (HAdV-B3) has an apparently stable genome yet remains a major circulating and problematic respiratory pathogen. Comparisons of the prototype genome to genomes from three current field strains, including two isolated from epidemics, and a laboratory strain, yielded small-scale nucleotide variati...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2009.10.052

    authors: Mahadevan P,Seto J,Tibbetts C,Seto D

    更新日期:2010-02-05 00:00:00

  • Expression of SV40 receptors on apical surfaces of polarized epithelial cells.

    abstract::We have investigated the interaction of SV40 virions with polarized monkey kidney epithelial cells. Virions were tagged with biotin to facilitate their detection and were found to retain full infectivity. When polarized Vero C1008 cells were incubated with biotinylated virions followed by a strepavidin-rhodamine conju...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(92)91225-j

    authors: Basak S,Turner H,Compans RW

    更新日期:1992-09-01 00:00:00

  • The endogenous langur type D retrovirus PO-1-Lu and its exogenous counterparts in macaque and langur monkeys.

    abstract::PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis t...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/s0042-6822(03)00548-8

    authors: Sommerfelt MA,Harkestad N,Hunter E

    更新日期:2003-10-25 00:00:00

  • N-methyl-N-nitrosourea-induced T-lymphomas of AKR/J mice contain somatically acquired ecotropic-like murine leukemia proviruses.

    abstract::We have studied somatically murine leukemia proviral integrations in primary N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas of AKR/J mice. The majority of MNU-induced lymphomas contain newly acquired murine leukemia proviral sequences. In contrast to spontaneous AKR/J lymphomas which contain multiple integratio...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(88)90638-1

    authors: Richie ER,Angel JM,McEntire B

    更新日期:1988-05-01 00:00:00

  • Morphological changes contribute to apoptotic cell death and are affected by caspase-3 and caspase-6 inhibitors during red sea bream iridovirus permissive replication.

    abstract::Red sea bream iridovirus (RSIV) of the Iridoviridae family is a causative agent of lethal infections in many cultured marine fish species in southwestern Japan. RSIV-induced apoptosis was divided as follows: (1). cell shrinkage and rounding at the early apoptotic stage, (2). cell enlargement at the middle apoptotic st...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2004.02.006

    authors: Imajoh M,Sugiura H,Oshima S

    更新日期:2004-05-01 00:00:00

  • Brome mosaic virus coat protein inhibits viral RNA synthesis in vitro.

    abstract::In vitro, the coat protein of brome mosaic virus (BMV) inhibited RNA synthesis by replicase extracted from BMV-infected barley leaves. The inhibition was due to the interaction of coat protein with BMV RNA. Under the same conditions, no inhibition by TMV coat protein or bovine serum albumin was detected. For the compl...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(87)90232-7

    authors: Horikoshi M,Nakayama M,Yamaoka N,Furusawa I,Shishiyama J

    更新日期:1987-05-01 00:00:00

  • Molecular epidemiology of betanodavirus-sequence analysis strategies and quasispecies influence outbreak source attribution.

    abstract::The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2012.10.011

    authors: Hick P,Gore K,Whittington R

    更新日期:2013-02-05 00:00:00

  • Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre.

    abstract::There are more than 100 known adenovirus serotypes, including 50 human serotypes. They can infect all 5 major vertebrate classes but only Aviadenovirus infecting birds and Mastadenovirus infecting mammals have been well studied. CELO (chicken embryo lethal orphan) adenovirus is responsible for mild respiratory patholo...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2008.05.011

    authors: El Bakkouri M,Seiradake E,Cusack S,Ruigrok RW,Schoehn G

    更新日期:2008-08-15 00:00:00

  • Intracellular factors, but not virus receptor levels, influence the age-related outcome of DHBV infection of ducks.

    abstract::Previous serological studies of experimental infection with duck hepatitis B virus (DHBV) have shown that the outcome of infection depends largely on the age of the duck at the time of inoculation. To examine the hypothesis that decreased susceptibility with increased age might be due to the loss of the virus receptor...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(92)90017-j

    authors: Qiao M,Gowans EJ,Burrell CJ

    更新日期:1992-02-01 00:00:00

  • Autographa californica multiple nucleopolyhedrovirus ac142, a core gene that is essential for BV production and ODV envelopment.

    abstract::Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac142 is a baculovirus core gene and encodes a protein previously shown to associate with occlusion-derived virus (ODV). To determine its role in the baculovirus life cycle, we used the AcMNPV bacmid system to generate an ac142 deletion virus (AcBAC(ac142KO...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2007.10.019

    authors: McCarthy CB,Dai X,Donly C,Theilmann DA

    更新日期:2008-03-15 00:00:00

  • Assembly of HIV GAG-B-galactosidase fusion proteins into virus particles.

    abstract::We have studied the assembly of human immunodeficiency virus (HIV-1) Gag-B-galactosidase (Gag-B-gal; GBG) fusion proteins into HIV particles in the presence of HIV Gag proteins. Release of fusion proteins from cells was measured by assay of media versus cellular B-gal activities and was dependent on co-expression of u...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1994.1215

    authors: Wang CT,Stegeman-Olsen J,Zhang Y,Barklis E

    更新日期:1994-05-01 00:00:00

  • The role of the AcMNPV 25K gene, "FP25," in baculovirus polh and p10 expression.

    abstract::A previous study showed that an Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) 25K mutant produced less polyhedrin protein than wild-type (Jarvis et al., J. Virol. 66, 6903-6911, 1992). In this study, the role of the 25K gene product (AcMNPV ORF 61) in baculovirus gene expression was further in...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1996.0625

    authors: Harrison RL,Jarvis DL,Summers MD

    更新日期:1996-12-01 00:00:00

  • The tobamovirus capsid protein functions as a host-specific determinant of long-distance movement.

    abstract::The tobamoviruses, tobacco mosaic virus (TMV) and Odontoglossum ringspot virus (ORSV), differ in the range of plant species that each can systemically infect. Both viruses systemically infect Nicotiana benthamiana similarly, but differ in the ability to systemically infect tobacco (N. tabacum). ORSV is confined to the...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1993.1107

    authors: Hilf ME,Dawson WO

    更新日期:1993-03-01 00:00:00

  • Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death.

    abstract::Langat (LGT) flavivirus, derived from infectious full-length cDNA clone 636, was investigated for its apoptotic activities in mouse neuroblastoma (Neuro-2a) and simian kidney (Vero and LLC-MK(2)) cells. The hallmark of apoptosis, cleavage of cellular DNA, was observed 48 h after infection of Vero, LLC-MK(2), and Neuro...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.2001.0980

    authors: Prikhod'ko GG,Prikhod'ko EA,Cohen JI,Pletnev AG

    更新日期:2001-08-01 00:00:00

  • The large subunit of herpes simplex virus type 1 ribonucleotide reductase: expression in Escherichia coli and purification.

    abstract::The open reading frame of the large subunit (R1) of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase has been positioned downstream of the phage T7 gene 10 promoter in the expression vector, pET. Transformation of this recombinant plasmid into Escherichia coli BL21 DE3 cells containing the T7 RNA polymeras...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(91)90627-n

    authors: Furlong J,Conner J,McLauchlan J,Lankinen H,Galt C,Marsden HS,Clements JB

    更新日期:1991-06-01 00:00:00

  • Altered dinucleotide content within the latently transcribed regions of the DNA of alpha herpes viruses--implications for latent RNA expression and DNA structure.

    abstract::The alphaherpesviruses establish latent infections in sensory neuronal cells, during which a number of latency-associated RNA transcripts (LATs) are produced. The reasons for the production of the LATs, however, and the mechanism by which the LAT region of the genome remains active during latency are unknown. Here we ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1995.1267

    authors: Coffin RS,Howard MK,Latchman DS

    更新日期:1995-06-01 00:00:00

  • Deletion analysis of four of eighteen late gene expression factor gene homologues of the baculovirus, BmNPV.

    abstract::Nucleotide sequence analysis of the genome of the baculovirus Bombyx mori nuclear polyhedrosis virus (BmNPV) identified 18 homologues of the Autographa californica NPV (AcNPV) lefs (late expression factor genes). These BmNPV lefs showed high (73-98%) amino acid sequence identities to AcNPV lefs and were localized to s...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1997.8457

    authors: Gomi S,Zhou CE,Yih W,Majima K,Maeda S

    更新日期:1997-03-31 00:00:00

  • Bovine aortic endothelial cells are susceptible to hantavirus infection; a new aspect in hantavirus ecology.

    abstract::Hantaviruses are enveloped RNA viruses that belong to the family Bunyaviridae. They are the causative agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Hantaviruses show a worldwide distribution with specific rodent species as natural hosts. It is known that rodents can tr...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2003.09.006

    authors: Muranyi W,Kehm R,Bahr U,Müller S,Handermann M,Darai G,Zeier M

    更新日期:2004-01-05 00:00:00

  • Induction of cell death by tospoviral protein NSs and the motif critical for cell death does not control RNA silencing suppression activity.

    abstract::Groundnut bud necrosis virus induces necrotic symptoms in different hosts. Previous studies showed reactive oxygen species-mediated programmed cell death (PCD) resulted in necrotic symptoms. Transgenic expression of viral protein NSs mimics viral symptoms. Here, we showed a role for NSs in influencing oxidative burst ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2017.05.003

    authors: Singh A,Permar V,Jain RK,Goswami S,Kumar RR,Canto T,Palukaitis P,Praveen S

    更新日期:2017-08-01 00:00:00

  • Genomic diversity and interspecies host infection of alpha12 Macaca fascicularis papillomaviruses (MfPVs).

    abstract::Alpha human papillomaviruses (HPVs) are among the most common sexually transmitted agents of which a subset causes cervical neoplasia and cancer in humans. Alpha-PVs have also been identified in non-human primates although few studies have systematically characterized such types. We cloned and characterized 10 distinc...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2009.07.012

    authors: Chen Z,van Doorslaer K,DeSalle R,Wood CE,Kaplan JR,Wagner JD,Burk RD

    更新日期:2009-10-25 00:00:00