当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Morphological changes contribute to apoptotic cell death and are affected by caspase-3 and caspase-6 inhibitors during red sea bream iridovirus permissive replication.

Morphological changes contribute to apoptotic cell death and are affected by caspase-3 and caspase-6 inhibitors during red sea bream iridovirus permissive replication.

Abstract：

:Red sea bream iridovirus (RSIV) of the Iridoviridae family is a causative agent of lethal infections in many cultured marine fish species in southwestern Japan. RSIV-induced apoptosis was divided as follows: (1). cell shrinkage and rounding at the early apoptotic stage, (2). cell enlargement at the middle apoptotic stage, (3). formation of apoptotic body-like vesicles at the late apoptotic stage and phagocytosis by neighboring cells, and (4). loss of membrane integrity in apoptotic body-like vesicles without phagocytosis by neighboring cells. By affinity labeling, RSIV-induced apoptosis included caspase-dependent apoptosis. RSIV infection caused cell rounding but not cell enlargement or formation of apoptotic body-like vesicles and further restricted part of the structural protein synthesis in the presence of caspase-3 and -6 inhibitors. These findings showed the involvement of caspase-3 and -6 in the morphological changes at the middle and late apoptotic stages and viral protein synthesis in the late stage of RSIV infection.

journal_name

Virology

journal_title

Virology

authors

Imajoh M,Sugiura H,Oshima S

doi

10.1016/j.virol.2004.02.006

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

220-30

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042682204000819

journal_volume

322

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Pirates of the Caudovirales.

    abstract：:Molecular piracy is a biological phenomenon in which one replicon (the pirate) uses the structural proteins encoded by another replicon (the helper) to package its own genome and thus allow its propagation and spread. Such piracy is dependent on a complex web of interactions between the helper and the pirate that occu...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1016/j.virol.2012.10.028

    authors： Christie GE,Dokland T

    更新日期：2012-12-20 00:00:00

  • The cytoplasmic tail of Herpes simplex virus glycoprotein H binds to the tegument protein VP16 in vitro and in vivo.

    abstract：:During Herpes simplex virus envelopment, capsids, tegument polypeptides, and membrane proteins assemble at the site of budding and a cellular lipid bilayer becomes refashioned into a spherical envelope. Though the molecular interactions driving these events are poorly understood, several lines of evidence suggest that...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.08.023

    authors： Gross ST,Harley CA,Wilson DW

    更新日期：2003-12-05 00:00:00

  • Mutation and replacement of the 16-kDa protein gene in RNA-1 of tobacco rattle virus.

    abstract：:The function of the 16-kDa protein encoded by tobacco rattle virus (TRV) RNA-1 was investigated by a mutational analysis of the 16-kDa protein gene. Transcripts of TRV RNA-1 produced from a full-length cDNA clone of TRV RNA-1 (SYM strain) remained infectious when the 16-kDa protein gene was disrupted by premature term...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90601-7

    authors： Guilford PJ,Ziegler-Graff V,Baulcombe DC

    更新日期：1991-06-01 00:00:00

  • HPV16 E1--E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm.

    abstract：:The human papillomavirus type 16 E1--E4 protein is expressed abundantly in cells supporting viral DNA amplification, but its expression is lost during malignant progression. In cell culture, 16E1--E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. Here, we ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.02.024

    authors： Davy CE,Ayub M,Jackson DJ,Das P,McIntosh P,Doorbar J

    更新日期：2006-05-25 00:00:00

  • Nucleic acid species related to the satellite RNA of turnip crinkle virus in turnip plants and virus particles.

    abstract：:Multiple RNA species which hybridize to a cloned cDNA probe of the turnip crinkle virus satellite RNA (S-TCV) are found both in virions and in plants infected with virus particles containing S-TCV. At least six of these RNAs appear to be multimeric forms of the satellite RNA based on their migration in denaturing gels...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90273-3

    authors： Altenbach SB,Howell SH

    更新日期：1984-04-15 00:00:00

  • Association of reovirus proteins with the structural matrix of infected cells.

    abstract：:The interaction of reovirus with the cytoskeleton was investigated. The soluble components of infected cells were extracted with the nonionic detergent NP-40 in a physiological buffer, and a cytoskeletal extract was prepared from the detergent-insoluble fraction. We observed a selective association of viral-specified ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90464-8

    authors： Mora M,Partin K,Bhatia M,Partin J,Carter C

    更新日期：1987-08-01 00:00:00

  • A subtype of human papillomavirus 5 (HPV-5b) and its subgenomic segment amplified in a carcinoma: nucleotide sequences and genomic organizations.

    abstract：:A subtype of human papillomavirus 5 (HPV-5b) is closely associated with carcinomas in the disease epidermodysplasia verruciformis (EV). The complete genome was cloned from virus particles in benign lesions of a patient with EV and sequenced: it was 7779 nucleotides long and consisted of six open reading frames (ORFs) ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)91013-7

    authors： Yabe Y,Sakai A,Hitsumoto T,Kato H,Ogura H

    更新日期：1991-08-01 00:00:00

  • Identification and characterization of a novel gene encoding an RGD-containing protein in large yellow croaker iridovirus.

    abstract：:Many virus-encoded RGD-containing proteins have been reported to play important roles in virus attachment and entry. Here we report the identification and functional characterization of a gene encoding an RGD-containing protein (037L) from large yellow croaker iridovirus (LYCIV), a causative agent of epizootics among ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.07.004

    authors： Ao J,Chen X

    更新日期：2006-11-25 00:00:00

  • Sequence-specific methylation inhibits the activity of the Epstein-Barr virus LMP 1 and BCR2 enhancer-promoter regions.

    abstract：:We reported earlier that variable expression of the Epstein-Barr virus (EBV) encoded membrane protein LMP 1 in nasopharyngeal carcinoma and the host-cell-phenotype-dependent activity of the BCR2 promoter (one of the possible initiator sites for transcripts of Epstein-Barr nuclear antigens) in Burkitt's lymphoma (BL) l...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1229

    authors： Minarovits J,Hu LF,Minarovits-Kormuta S,Klein G,Ernberg I

    更新日期：1994-05-01 00:00:00

  • Sequence analysis of the complete genome of Trichoplusia ni single nucleopolyhedrovirus and the identification of a baculoviral photolyase gene.

    abstract：:The genome of the Trichoplusia ni single nucleopolyhedrovirus (TnSNPV), a group II NPV which infects the cabbage looper (T. ni), has been completely sequenced and analyzed. The TnSNPV DNA genome consists of 134,394 bp and has an overall G + C content of 39%. Gene analysis predicted 144 open reading frames (ORFs) of 15...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.04.041

    authors： Willis LG,Seipp R,Stewart TM,Erlandson MA,Theilmann DA

    更新日期：2005-08-01 00:00:00

  • Cucumber mosaic virus mutants with altered physical properties and defective in aphid vector transmission.

    abstract：:Two mutant strains of cucumber mosaic virus (CMV) were investigated with respect to virion stability and molecular determinants of aphid vector transmission. The mutant 2A1-MT-60x, derived from the mechanically passaged wild type 2A1-AT, is poorly transmissible by the aphid Aphis gossypii and not transmissible by the ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0569

    authors： Ng JC,Liu S,Perry KL

    更新日期：2000-10-25 00:00:00

  • Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells.

    abstract：:We have previously shown that peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists inhibited the inflammatory response of RSV-infected human lung epithelial cells. In this study, we supply evidence that specific PPARgamma agonists (15d-PGJ2, ciglitazone, troglitazone, Fmoc-Leu) efficiently blocked the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.03.008

    authors： Arnold R,König W

    更新日期：2006-07-05 00:00:00

  • Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice.

    abstract：:Fixed rabies virus strains (ERA and CVS) produce a fatal paralytic disease in mice after intracerebral or intramuscular injection. Some antigenic mutants of both CVS and ERA viruses with a substitution in position 333 of the glycoprotein (arginine is replaced either by a glutamine, a glycine, or an isoleucine) are tot...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90122-0

    authors： Tuffereau C,Leblois H,Bénéjean J,Coulon P,Lafay F,Flamand A

    更新日期：1989-09-01 00:00:00

  • HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.

    abstract：:HIV-1 Vpu antagonizes the block to particle release mediated by CD317 (BST-2/HM1.24/Tetherin) via incompletely understood mechanisms. Vpu and CD317 partially reside in cholesterol-rich lipid rafts where HIV-1 budding preferentially occurs. Here we find that lipid raft association of ectopically expressed or endogenous...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.12.008

    authors： Fritz JV,Tibroni N,Keppler OT,Fackler OT

    更新日期：2012-03-01 00:00:00

  • Identification, expression, and processing of an 87-kDa polypeptide encoded by ORF 1a of the coronavirus infectious bronchitis virus.

    abstract：:Nucleotide sequence analysis has shown previously that the genomic-length mRNA (mRNA1) of the coronavirus infectious bronchitis virus (IBV) contains two large open reading frames (ORFs), 1a and 1b, with the potential to encode polyproteins of approximately 441 and 300 kDa, respectively. We have characterized the speci...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1128

    authors： Liu DX,Tibbles KW,Cavanagh D,Brown TD,Brierley I

    更新日期：1995-04-01 00:00:00

  • Hyper-phosphorylation of nsp2-related proteins of porcine reproductive and respiratory syndrome virus.

    abstract：:Viruses exploit phosphorylation of both viral and host proteins to support viral replication. In this study, we demonstrate that porcine reproductive and respiratory syndrome virus replicase nsp2, and two nsp2-related -2/-1 frameshifting products, nsp2TF and nsp2N, are hyper-phosphorylated. By mapping phosphorylation ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2020.01.018

    authors： Shang P,Yuan F,Misra S,Li Y,Fang Y

    更新日期：2020-04-01 00:00:00

  • Biological characterization of infectious molecular clones derived from a human immunodeficiency virus type-1 isolate with rapid/high replicative capacity.

    abstract：:In order to molecularly characterize rapidly and slowly replicating HIV-1 variants, molecular clones were obtained from a rapid/high virus isolate. This isolate, 4803, had only been passaged in peripheral blood mononuclear cells (PBMC) prior to cloning. Molecular cloning was done in bacteriophage lambda-dash using hig...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90469-r

    authors： Fredriksson R,Stålhanske P,von Gegerfelt A,Lind B,Aman P,Rassart E,Fenyö EM

    更新日期：1991-03-01 00:00:00

  • Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4.

    abstract：:Rotavirus (RV) is the leading cause of infantile gastroenteritis worldwide. RV nonstructural protein 4 (NSP4), the first characterized viral enterotoxin, is a 28-kDa glycoprotein that has pleiotropic functions in RV infection and pathogenesis. NSP4 has multiple forms enabling it to perform its different functions. Dis...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.11.021

    authors： Hyser JM,Zeng CQ,Beharry Z,Palzkill T,Estes MK

    更新日期：2008-03-30 00:00:00

  • Synthesis in vitro of infectious RNA copies of the virulent satellite of turnip crinkle virus.

    abstract：:RNA copies, synthesized in vitro, of the virulent satellite (RNA C) of turnip crinkle virus (TCV) infect plants when coinoculated with helper virus RNA. RNA C is a small linear RNA of about 355 bases which intensifies TCV symptoms in infected plants. Full-length cDNA copies of the satellite were inserted in an express...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90445-4

    authors： Simon AE,Howell SH

    更新日期：1987-01-01 00:00:00

  • Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.

    abstract：:Many tumors, including cervical carcinoma, show dysregulated expression of the microRNA processing machinery, specifically DROSHA and DICER. Some cervical cancers exhibit chromosome 5p amplifications and DROSHA is the most significantly upregulated transcript and is observed in all tumors with 5p gain. DROSHA and DICE...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.04.022

    authors： Harden ME,Munger K

    更新日期：2017-07-01 00:00:00

  • Modified HIV envelope proteins with enhanced binding to neutralizing monoclonal antibodies.

    abstract：:The target for neutralizing antibodies against human immunodeficiency virus (HIV) is the trimeric Env protein on the native virion. Conserved neutralizing epitopes of receptor binding sites are located in the recessed core of the Env protein, partially masked by glycosylations and variable loops. In this study, we hav...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.10.005

    authors： Kang SM,Quan FS,Huang C,Guo L,Ye L,Yang C,Compans RW

    更新日期：2005-01-05 00:00:00

  • Isolation of mutations of the phage Mu ner gene.

    abstract：:A method was devised which allows the easy detection of mutations within the ner gene of Mu DNA. This method is based upon the observation that a transcriptional gene A-galK fusion containing the complete ner gene and the cts62 allele does not express the galK gene in an Escherichia coli strain lacking functional inte...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90621-6

    authors： König U,Kirschner P,Schumann W

    更新日期：1988-05-01 00:00:00

  • Binding of adenovirus to its receptors in mouse astrocytes induces c-fos proto-oncogene and apoptosis.

    abstract：:We have demonstrated that Ad.betaGal, a broadly used adenoviral vector of serotype 5, binds and induces proto-oncogene c-fos expression in quiescent cultures of mouse brain astrocytes. As observed in Northern blots, the expression of this immediate early gene is induced by viral infection in a dose-dependent manner, p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1426

    authors： Rubio N,Martin-Clemente B

    更新日期：2002-06-05 00:00:00

  • The hypervariable region 1 protein of hepatitis C virus broadly reactive with sera of patients with chronic hepatitis C has a similar amino acid sequence with the consensus sequence.

    abstract：:Hypervariable region 1 (HVR1) proteins of hepatitis C virus (HCV) have been reported to react broadly with sera of patients with HCV infection. However, the variability of the broad reactivity of individual HVR1 proteins has not been elucidated. We assessed the reactivity of 25 different HVR1 proteins (genotype 1b) wi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0004

    authors： Watanabe K,Yoshioka K,Ito H,Ishigami M,Takagi K,Utsunomiya S,Kobayashi M,Kishimoto H,Yano M,Kakumu S

    更新日期：1999-11-10 00:00:00

  • Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus.

    abstract：:The N-terminal domains of the NS1 protein of influenza B virus (NS1B protein) and the NS1 protein of influenza A virus (NS1A protein) share one function: binding double-stranded RNA (dsRNA). Here we show that the N-terminal domain of the NS1B protein possesses an additional function that is not shared by its NS1A coun...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1663

    authors： Yuan W,Aramini JM,Montelione GT,Krug RM

    更新日期：2002-12-20 00:00:00

  • Inhibition of vaccinia virus replication by N-(phosphonoacetyl)-L-aspartate: differential effects on viral gene expression result from a reduced pyrimidine nucleotide pool.

    abstract：:The replication of vaccinia virus was reduced by 3 logs in cells that had been treated before and during infection with a concentration of N-(phosphonoacetyl)-L-aspartate (PALA) which lowered the UTP and CTP to 5 and 20% of controls, respectively, without affecting cell viability. The antiviral activity of PALA was re...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8735

    authors： Katsafanas GC,Grem JL,Blough HA,Moss B

    更新日期：1997-09-15 00:00:00

  • The role of the PI3K-Akt signal transduction pathway in Autographa californica multiple nucleopolyhedrovirus infection of Spodoptera frugiperda cells.

    abstract：:Many viruses activate the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, thereby modulating diverse downstream signaling pathways associated with antiapoptosis, proliferation, cell cycling, protein synthesis and glucose metabolism, in order to augment their replication. To date, the role of the PI3K-Akt p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.06.007

    authors： Xiao W,Yang Y,Weng Q,Lin T,Yuan M,Yang K,Pang Y

    更新日期：2009-08-15 00:00:00

  • Characterization of human papillomavirus-11 mRNAs expressed in the context of autonomously replicating viral genomes.

    abstract：:We have previously adapted an experimental system which supports autonomous replication of human papillomavirus-11 (HPV-11) genomic DNA in a human squamous carcinoma cell line (SCC-4) following electroporation of linearized viral DNA. This system allows evaluation of HPV-11 transcription in the context of replicating ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0298

    authors： Renaud KJ,Cowsert LM

    更新日期：1996-06-01 00:00:00

  • Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence.

    abstract：:In this paper we present a technique developed to physically locate the HSV-1 gene(s) which restore neurovirulence to a non-neurovirulent HSV intertypic recombinant described in the preceding report. In brief, tissue culture cells are co-transfected with unit length RE6 DNA and restriction endonuclease fragmented HSV-...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90544-5

    authors： Thompson RL,Wagner EK,Stevens JG

    更新日期：1983-11-01 00:00:00

  • Protein composition of the vaccinia virus mature virion.

    abstract：:The protein content of vaccinia virus mature virions, purified by rate zonal and isopycnic centrifugations and solubilized by SDS or a solution of urea and thiourea, was determined by the accurate mass and time tag technology which uses both tandem mass spectrometry and Fourier transform-ion cyclotron resonance mass s...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.08.025

    authors： Resch W,Hixson KK,Moore RJ,Lipton MS,Moss B

    更新日期：2007-02-05 00:00:00