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Murine leukemia virus recombinants that use phosphate transporters for cell entry induce similar spongiform encephalomyelopathies in newborn mice.

Abstract：

:Amphotropic Moloney-murine leukemia virus recombinants (Mo-AmphoV) induce a severe spongiform encephalomyelopathy in newborn mice. We show here that a coisogenic recombinant with a 10A1-MuLV host range (Mo-10A1V) also induces a neurodegenerative disease, clinically characterized by mild tremor and ataxia. Spongiform lesions are most severe in the metencephalon and mesencephalon but extend into the prosencephalon and spinal cord. Significantly, the quality of histopathology was indistinguishable between Mo-AmphoV and Mo-10A1V, probably reflecting a final common pathogenic pathway. Common receptor use thus may be an important determinant in the pathogenicity of these viruses. These results have implications for the clinical use of retroviral pseudotypes that use phosphate transporters for cell entry.

journal_name

Virology

journal_title

Virology

authors

Münk C,Thomsen S,Stocking C,Löhler J

doi

10.1006/viro.1998.9476

subject

Has Abstract

pub_date

1998-12-20 00:00:00

pages

318-23

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(98)99476-4

journal_volume

252

pub_type

杂志文章

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