当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.

Abstract：

:The human T cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is etiologically linked to the genesis of adult T cell leukemia (ATL) as well as HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Emerging evidence suggests that the pathogenicity of HTLV-I involves deregulated activation of immune cells, especially T lymphocytes, although the underlying mechanism remains unclear. In this study, we demonstrate that HTLV-I Tax induces the aberrant expression of CD40, a member of the tumor necrosis factor receptor (TNFR) family that plays an important role in lymphocyte activation and differentiation. In a panel of HTLV-I-transformed T cell lines analyzed, CD40 expression was highly elevated compared to HTLV-I-negative T cells. Using Tax mutants and a genetically manipulated T cell system, we demonstrated that Tax-induced CD40 expression required the NF-kappaB signaling pathway. In addition, ligation of CD40 on T cells with recombinant CD40L elicited NF-kappaB activation, suggesting that the CD40 pathway is intact and may participate in a positive regulatory loop in T cells. CD40 ligation strongly synergized with Tax to activate NF-kappaB, suggesting that CD40 signals may costimulate Tax-mediated NF-kappaB activation, particularly when Tax is expressed at low levels. Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis.

journal_name

Virology

journal_title

Virology

authors

Harhaj EW,Harhaj NS,Grant C,Mostoller K,Alefantis T,Sun SC,Wigdahl B

doi

10.1016/j.virol.2004.12.008

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

145-58

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(04)00841-4

journal_volume

333

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Differential virus restriction patterns of rhesus macaque and human APOBEC3A: implications for lentivirus evolution.

    abstract：:The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins (A3A-H) are known to restrict various retroviruses and retroelements, but the full complement of rhesus macaque A3 proteins remains unclear. We report the isolation and characterization of the hA3A homologue from r...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.07.017

    authors： Schmitt K,Guo K,Algaier M,Ruiz A,Cheng F,Qiu J,Wissing S,Santiago ML,Stephens EB

    更新日期：2011-10-10 00:00:00

  • Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus.

    abstract：:The surface of the mature dengue virus (DENV) particle consists of 90 envelope (E) protein dimers that mediate both receptor binding and fusion. The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralizat...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.05.042

    authors： Gromowski GD,Barrett AD

    更新日期：2007-09-30 00:00:00

  • Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.

    abstract：:Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis. To this end, we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.07.019

    authors： Meissner EG,Duus KM,Gao F,Yu XF,Su L

    更新日期：2004-10-10 00:00:00

  • High rate of infection with the human T-cell leukemia retrovirus type II in four Indian populations of Argentina.

    abstract：:Sera from 215 non-drug-injecting Toba and Mataco-Mataguayo pure Indians belonging to four communities in northern Argentina were examined using assays that allow differentiation between reactivities due to type-specific antigens of the human T-cell leukemia/lymphoma virus (HTLV). Three of these populations have very l...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1631

    authors： Ferrer JF,Del Pino N,Esteban E,Sherman MP,Dube S,Dube DK,Basombrio MA,Pimentel E,Segovia A,Quirulas S

    更新日期：1993-12-01 00:00:00

  • SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids.

    abstract：:Polyomaviral vectors are generated by transfecting 293T cells with three sets of DNAs: DNA for the expression of simian virus 40 (SV40) T antigen; DNA for the expression of SV40 capsid proteins, and vector DNA harboring a reporter gene expression cassette carrying a SV40 origin. The vector DNA harbors a minimal sequen...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.06.032

    authors： Nakanishi A,Chapellier B,Maekawa N,Hiramoto M,Kuge T,Takahashi RU,Handa H,Imai T

    更新日期：2008-09-15 00:00:00

  • Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac₂₅₁ infection of macaques.

    abstract：:We characterized three subsets of NK cells in blood, and two subsets in mucosal tissues. SIVmac251 infection increased total and CD16(+) NK cells in the blood. In the rectum, we observed a significant increase in total and NKG2A(+) NK cells during SIV infection. In contrast, the NKp44(+) subset significantly depleted ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.12.003

    authors： Liyanage NP,Gordon SN,Doster MN,Pegu P,Vaccari M,Shukur N,Schifanella L,Pise-Masison CA,Lipinska D,Grubczak K,Moniuszko M,Franchini G

    更新日期：2014-02-01 00:00:00

  • Evaluation of antibody parameters as potential correlates of protection or enhancement by experimental vaccines to equine infectious anemia virus.

    abstract：:We previously demonstrated in trials of a variety of experimental vaccines to equine infectious anemia virus (EIAV) a remarkable spectrum of efficacy ranging from sterilizing protection to severe enhancement of virus replication and disease, depending on the immunization strategy used. This range of vaccine efficacy o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9939

    authors： Hammond SA,Raabe ML,Issel CJ,Montelaro RC

    更新日期：1999-09-30 00:00:00

  • Viral spliced RNA are produced, encapsidated and reverse transcribed during in vivo woodchuck hepatitis virus infection.

    abstract：:By the use of reverse transcription followed by polymerase chain reaction (RT-PCR), we have identified one shorter than full-length, pregenomic viral RNA species in liver samples of woodchucks chronically infected with the woodchuck hepatitis virus (WHV). The spliced WHV RNA of about 2.4 kb in length was cloned and pa...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)91205-9

    authors： Hantz O,Baginski I,Fourel I,Chemin I,Trepo C

    更新日期：1992-09-01 00:00:00

  • Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A.

    abstract：:Although human polyomavirus JC (JCV) is known to cause progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals, the mechanism by which JCV crosses the blood-brain barrier (BBB) remains unclear. To test our hypothesis that cell-free JCV gains entry into the brain by infecting endothelial cells...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.02.018

    authors： Chapagain ML,Verma S,Mercier F,Yanagihara R,Nerurkar VR

    更新日期：2007-07-20 00:00:00

  • Relationship of oligomerization to DNA binding of Wheat dwarf virus RepA and Rep proteins.

    abstract：:Members of the genus Mastrevirus (family Geminiviridae) produce a complementary-sense (c-sense) transcription unit with the potential to encode two proteins, RepA and Rep. In the present work, we have studied the DNA-protein complexes formed by the Wheat dwarf virus (WDV) RepA protein within the WDV large intergenic r...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0412

    authors： Missich R,Ramirez-Parra E,Gutierrez C

    更新日期：2000-07-20 00:00:00

  • Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus.

    abstract：:Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.03.015

    authors： Inn KS,Kim Y,Aigerim A,Park U,Hwang ES,Choi MS,Kim YS,Cho NH

    更新日期：2018-05-01 00:00:00

  • Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells.

    abstract：:The current antiretroviral therapy (ART) can effectively reduce plasma HIV loads to undetectable levels, but cannot eliminate latently infected resting memory CD4 T cells that persist for the lifetime of infected patients. Therefore, designing new therapeutic approaches to eliminate these latently infected cells or th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.08.002

    authors： Sahu GK,Sango K,Selliah N,Ma Q,Skowron G,Junghans RP

    更新日期：2013-11-01 00:00:00

  • Proteolytic maturation of the 206-kDa nonstructural protein encoded by turnip yellow mosaic virus RNA.

    abstract：:The longest open reading frame of turnip yellow mosaic virus genomic RNA (ORF-206) encodes a 206-kDa nonstructural protein. The most prominent in vitro translation products of ORF-206 are the full-length p206 and a shorter N-coterminal 150-kDa protein. We have confirmed these assignments by immunoprecipitation of in v...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90851-2

    authors： Bransom KL,Weiland JJ,Dreher TW

    更新日期：1991-09-01 00:00:00

  • Effects of egg-adaptation on the receptor-binding properties of human influenza A and B viruses.

    abstract：:Propagation of human influenza viruses in embryonated chicken eggs (CE) results in the selection of variants with amino acid substitutions near the receptor-binding site of the hemagglutinin (HA) molecule. To evaluate the mechanisms by which these substitutions enable human virus growth in CE, we studied the binding o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9732

    authors： Gambaryan AS,Robertson JS,Matrosovich MN

    更新日期：1999-06-05 00:00:00

  • High-level expression of the measles virus nucleocapsid protein by using a replication-deficient adenovirus vector: induction of an MHC-1-restricted CTL response and protection in a murine model.

    abstract：:Replication-deficient adenovirus (Ad) vectors provide an efficient technology for direct DNA delivery to cells both in vitro and in vivo. We have inserted the measles virus nucleoprotein (N) gene under the control of the strong constitutive CMV major IE promoter into an Ad type 5 E1- vector to produce the recombinant ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1362

    authors： Fooks AR,Schadeck E,Liebert UG,Dowsett AB,Rima BK,Steward M,Stephenson JR,Wilkinson GW

    更新日期：1995-07-10 00:00:00

  • Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage.

    abstract：:Endogenous feline leukemia viruses (enFeLVs) occur in the germ lines of the domestic cat and related wild species (genus Felis). We sequenced the long terminal repeats and part of the env region of enFeLVs in domestic cats and five wild species. A total of 305 enFeLV sequences were generated across 17 individuals, dem...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.06.010

    authors： Polani S,Roca AL,Rosensteel BB,Kolokotronis SO,Bar-Gal GK

    更新日期：2010-09-30 00:00:00

  • Alterations in the hemagglutinin associated with adaptation of influenza B virus to growth in eggs.

    abstract：:In 1943 Burnet reported on changes in the hemagglutinating properties of human influenza virus which occurred during adaptation of the virus to growth in chicken eggs. Only recently has direct evidence been presented that these changes affect the antigenic properties of the virus. Schild et al. (G. C. Schild, J. S. Ox...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90105-9

    authors： Robertson JS,Naeve CW,Webster RG,Bootman JS,Newman R,Schild GC

    更新日期：1985-05-01 00:00:00

  • The SIVmac239 Pr55Gag isoform, SIV p43, suppresses proteolytic cleavage of Pr55Gag.

    abstract：:In human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) the gag gene encodes the precursor polyprotein Pr55Gag, which is cleaved by the viral protease to produce the major structural proteins. Recently, it has been shown that HIV and SIV gag RNAs contain internal ribosome entry sites (IR...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.10.003

    authors： Nicholson MG,Barber SA,Clements JE

    更新日期：2007-03-30 00:00:00

  • The V protein of human parainfluenza virus type 2 promotes RhoA-induced filamentous actin formation.

    abstract：:We previously demonstrated that human parainfluenza virus type 2 (hPIV-2) induces RhoA activation, which promotes its growth. RhoA controls the equilibrium between globular and filamentous actin (F-actin). We found that F-actin formation is induced by wild type (wt) hPIV-2 infection, and that inhibition of F-actin for...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.08.015

    authors： Ohta K,Matsumoto Y,Yumine N,Nishio M

    更新日期：2018-11-01 00:00:00

  • Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin.

    abstract：:Highly pathogenic alphaviruses display complex glycans on their surface. These glycans play a crucial role in viral pathogenesis by facilitating glycan-host interaction during viral entry which can be targeted. Various studies have reported antiviral activity of lectins that bind to the glycans present on the surface ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.10.009

    authors： Kaur R,Neetu,Mudgal R,Jose J,Kumar P,Tomar S

    更新日期：2019-01-02 00:00:00

  • Epstein-Barr virus replicative gene transcription during de novo infection of human thymocytes: simultaneous early expression of BZLF-1 and its repressor RAZ.

    abstract：:Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells. We and others have shown that EBV can also infect a subset of thymocytes. Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection. Circularization of the EBV genome was not detected. This is in con...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1200

    authors： Kelleher CA,Paterson RK,Dreyfus DH,Streib JE,Xu JW,Takase K,Jones JF,Gelfand EW

    更新日期：1995-04-20 00:00:00

  • Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus.

    abstract：:Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we describe the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.08.030

    authors： Mettelman RC,O'Brien A,Whittaker GR,Baker SC

    更新日期：2019-11-01 00:00:00

  • A cis-replication element functions in both orientations to enhance replication of Turnip crinkle virus.

    abstract：:Turnip crinkle virus (TCV) (family Tombusviridae, genus Carmovirus) is a positive-sense RNA virus containing a 4054-base genome. Previous results indicated that insertion of Hairpin 4 (H4) into a TCV-associated satellite RNA enhanced replication 6-fold in vivo (Nagy, P., Pogany, J., Simon, A. E., 1999. EMBO J. 18:5653...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.03.051

    authors： Sun X,Simon AE

    更新日期：2006-08-15 00:00:00

  • Domain structure, intracellular trafficking, and beta2-microglobulin binding of a major histocompatibility complex class I homolog encoded by molluscum contagiosum virus.

    abstract：:The MC80R gene of molluscum contagiosum virus (MCV) type 1 encodes a major histocompatibility complex (MHC) class I homolog that lacks several amino-acid residues critical for peptide binding by MHC molecules, contains an unusually long N-terminal hydrophobic domain possibly derived by triplication of a signal peptide...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9390

    authors： Senkevich TG,Moss B

    更新日期：1998-10-25 00:00:00

  • Recurrence of WHV integration in the b3n locus in woodchuck hepatocellular carcinoma.

    abstract：:Frequent occurrence of woodchuck hepatitis virus DNA (WHV DNA) integration into or in proximity to myc oncogenes and in the win locus of cellular genome in woodchuck hepatocellular carcinomas (HCC) has been described by several authors. We report a further cellular locus as a recurrent target for WHV integration in wo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.9936

    authors： Bruni R,Argentini C,D'Ugo E,Giuseppetti R,Ciccaglione AR,Rapicetta M

    更新日期：1995-12-01 00:00:00

  • Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice.

    abstract：:This study evaluates the role of antibody as an indicator of immunity to ocular challenge with herpes simplex virus (HSV). Two genotypes of mice, BALB/c or BALB/c with mu-chain knockout (muK/O; which lack functional B cells), were immunized systemically either with nonvirulent infectious virus or with a eukaryotic exp...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9613

    authors： Daheshia M,Deshpande S,Chun S,Kuklin NA,Rouse BT

    更新日期：1999-04-25 00:00:00

  • Use of herpes simplex virus thymidine kinase to improve the antiviral activity of zidovudine.

    abstract：:Many antiviral drugs must be metabolized to their active form by cellular enzymes. Their antiviral activity may therefore be limited by an inefficient metabolism, leading to low intracellular concentration of the active form or to the accumulation of toxic intermediate metabolites. Gene transfer might be used to overc...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8706

    authors： Guettari N,Loubière L,Brisson E,Klatzmann D

    更新日期：1997-09-01 00:00:00

  • Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy.

    abstract：:The prevalence of hepatitis B virus vaccine escape mutants has increased as a consequence of the introduction of global vaccination programs. Furthermore and as a consequence of the organization of the genome of hepatitis B virus (HBV) into overlapping reading frames, the selection of polymerase mutants during long-te...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1246

    authors： Torresi J,Earnest-Silveira L,Deliyannis G,Edgtton K,Zhuang H,Locarnini SA,Fyfe J,Sozzi T,Jackson DC

    更新日期：2002-02-15 00:00:00

  • The C-terminal tail of the gp41 transmembrane envelope glycoprotein of HIV-1 clades A, B, C, and D may exist in two conformations: an analysis of sequence, structure, and function.

    abstract：:In addition to the major ectodomain, the gp41 transmembrane glycoprotein of HIV-1 is now known to have a minor ectodomain that is part of the long C-terminal tail. Both ectodomains are highly antigenic, carry neutralizing and non-neutralizing epitopes, and are involved in virus-mediated fusion activity. However, data ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.04.015

    authors： Hollier MJ,Dimmock NJ

    更新日期：2005-07-05 00:00:00

  • Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells.

    abstract：:Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with di...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.04.009

    authors： Zhai RR,Jiang AP,Wang HB,Ma L,Ren XX,Jiang JF,Wu L,Wei JF,Wang JH

    更新日期：2013-08-01 00:00:00