Productive vs non-productive infection by cell-free varicella zoster virus of human neurons derived from embryonic stem cells is dependent upon infectious viral dose.

abstract：:Torque Teno Virus (TTV) has been assigned to the floating genus Anellovirus. TTV ssDNA genomes have a size of 3.6 to 3.8 kb and display up to 30% nucleotide diversity. The pathogenic potential of TTV is under investigation. To address a putative link of pathogenicity with the observed sequence variations, the transcri...

journal_title：Virology

authors： Mueller B,Maerz A,Doberstein K,Finsterbusch T,Mankertz A

更新日期：2008-11-10 00:00:00

abstract：:A cDNA clone containing all of the 26 S mRNA coding region of the RNA genome of Venezuelan equine encephalitis (VEE) virus, virulent strain Trinidad donkey (TRD), has been constructed and sequenced. The nucleotide and deduced amino acid sequences of the 26 S RNA of VEE virus conform to the general organization of the ...

journal_title：Virology

authors： Kinney RM,Johnson BJ,Brown VL,Trent DW

更新日期：1986-07-30 00:00:00

abstract：:The 37K protein of Chinese wheat mosaic virus (CWMV) belongs to the 30K superfamily of plant virus movement proteins. CWMV 37K trans-complemented the cell-to-cell spread of a movement-defective Potato virus X. CWMV 37K fused to enhanced green fluorescent protein localized to plasmodesmata and formed endoplasmic reticu...

journal_title：Virology

authors： Andika IB,Zheng S,Tan Z,Sun L,Kondo H,Zhou X,Chen J

更新日期：2013-01-20 00:00:00

abstract：:A non-optimal receptor-binding specificity of avian influenza viruses is believed to hamper their replication in humans; however, the magnitude of this restriction remains undefined. Here we generated recombinant viruses, R1 and R2, that differed solely by two amino acids in the receptor-binding site of their hemagglu...

journal_title：Virology

authors： Matrosovich M,Matrosovich T,Uhlendorff J,Garten W,Klenk HD

更新日期：2007-05-10 00:00:00

abstract：:New BVDV strains associated with very high mortalities, which killed about 25% of the veal calves in Quebec in 1993, have been isolated. In this study, characterization of the last two-thirds of the 5' untranslated region (5'UTR) of their genome and virus neutralization experiments with polyvalent antisera raised in d...

journal_title：Virology

authors： Pellerin C,van den Hurk J,Lecomte J,Tijssen P

更新日期：1994-09-01 00:00:00

abstract：:It has previously been shown that a far-upstream region of the herpes simplex virus immediate early (IE) gene 3 increases the expression of a linked thymidine kinase (TK) gene and also contains sequences which respond to stimulation of transcription by a virion component. The effects of altering the orientation and di...

journal_title：Virology

authors： Preston CM,Tannahill D

更新日期：1984-09-01 00:00:00

abstract：:The immediate-early transcripts of pseudorabies virus have been located in a region of the genome situated internally within the inverted repeat between map positions 0.99 and 0.95. A single immediate-early transcript (approximately 6 kb) can be detected both in the cytoplasmic and nuclear fractions of infected, cyclo...

journal_title：Virology

authors： Ihara S,Feldman L,Watanabe S,Ben-Porat T

更新日期：1983-12-01 00:00:00

abstract：:The human polyomavirus BK virus (BKV) is an important opportunistic pathogen whose disease prevalence continues to increase with the growing immunocompromised population. To date, the major determinant of replication in cell culture has not been formally proven. BKV exists as archetype virus and rearranged variants, w...

journal_title：Virology

authors： Broekema NM,Abend JR,Bennett SM,Butel JS,Vanchiere JA,Imperiale MJ

更新日期：2010-11-25 00:00:00

abstract：:Hematopoietic malignant cells of various types were isolated from ICFW mice inoculated as newborn or adult with F-MuLV and grafted into recipient mice. After repeated in vivo cell transplants, several recombinant polytropic viruses (also termed MCF or dualtropic viruses) were isolated from tumors by limiting dilution....

journal_title：Virology

authors： Della-Valle V,Wendling F,Sitbon M,Varlet P,Mathieu-Mahul D,Larsen CJ

更新日期：1990-10-01 00:00:00

abstract：:It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which ...

journal_title：Virology

authors： Davis CA,Parniak MA,Hughes SH

更新日期：2011-10-25 00:00:00

abstract：:In benign squamous lesions and in organotypic epithelial cultures, the human papillomavirus (HPV) E6 and E7 genes are transcriptionally up-regulated in differentiated, spinous keratinocytes. We previously identified sequence elements in the enhancer-promoter regions of HPV types 18 and 11 important for this promoter r...

journal_title：Virology

authors： Zhao W,Chow LT,Broker TR

更新日期：1999-01-20 00:00:00

abstract：:Rotavirus (RV) is the leading cause of infantile gastroenteritis worldwide. RV nonstructural protein 4 (NSP4), the first characterized viral enterotoxin, is a 28-kDa glycoprotein that has pleiotropic functions in RV infection and pathogenesis. NSP4 has multiple forms enabling it to perform its different functions. Dis...

journal_title：Virology

authors： Hyser JM,Zeng CQ,Beharry Z,Palzkill T,Estes MK

更新日期：2008-03-30 00:00:00

abstract：:Hepatitis C virus (HCV) core protein is a multifunctional protein interacting with cellular and viral proteins and promoters. A tetracycline-regulated system was used to generate a HepG2 Tet-Off cell line allowing regulated expression of a full-length (191 aa) and an N(c)-truncated core protein (160 aa). In this syste...

journal_title：Virology

authors： Erhardt A,Hassan M,Heintges T,Häussinger D

更新日期：2002-01-20 00:00:00

abstract：:The synthesis of linear duplex replicative structures (monomers, head-to-head, and tail-to-tail dimers) is an important hallmark of the productive phase of the adeno-associated virus (AAV) life cycle. These structures are generated by a strand-displacement replication mechanism and believed to be a reservoir for singl...

journal_title：Virology

authors： Musatov SA,Scully TA,Dudus L,Fisher KJ

更新日期：2000-09-30 00:00:00

abstract：:In March 2017, a novel highly pathogenic avian influenza A(H7N9) virus was detected at two commercial broiler breeder facilities in Tennessee, United States. In this study, a wild bird low pathogenic avian influenza A virus, A/blue-winged teal/Wyoming/AH0099021/2016(H7N9), was shown to be the probable precursor of the...

journal_title：Virology

authors： Li L,DeLiberto TJ,Killian ML,Torchetti MK,Wan XF

更新日期：2018-12-01 00:00:00

abstract：:Cytoplasmic poly(A)-containing RNA from parainfluenza virus 3-infected cells was used as template to construct a cDNA library that was cloned into the EcoRV site of the plasmid pMG5. The resulting clones were screened with [32P]-labeled cDNA probes made from infected and mock-infected cell mRNAs. The virus specificity...

journal_title：Virology

authors： Sánchez A,Banerjee AK

更新日期：1985-11-01 00:00:00

abstract：:Poliovirus readily establishes a persistent infection in the K562-Mu erythroleukemia cell strain. In this study, three additional K562 cell strains were analyzed for their responses to poliovirus infection and found to be quite variable. K562 cells obtained from the ATCC established a persistent infection, similar to ...

journal_title：Virology

authors： Benton PA,Murphy JW,Lloyd RE

更新日期：1995-10-20 00:00:00

abstract：:The NIa protein of potyviruses provides VPg and proteolytic functions during virus replication. It has also been shown to confer host genotype-specific movement functions in plants. Specifically, NIa from tobacco etch virus (TEV)-Oxnard, but not from most other strains, confers the ability to move long distances in Ni...

journal_title：Virology

authors： Schaad MC,Anderberg RJ,Carrington JC

更新日期：2000-08-01 00:00:00

abstract：:Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fu...

journal_title：Virology

authors： Wang W,Yang L,Huang X,Fu W,Pan D,Cai L,Ye J,Liu J,Xia N,Cheng T,Zhu H

更新日期：2017-12-01 00:00:00

abstract：:The initiation of reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires cellular tRNA(Lys,3) as a primer and occurs at a site in the viral RNA genome, designated as the primer binding site (PBS), which is complementary to the 3'-terminal 18 nucleotides of tRNA(Lys,3). We previously d...

journal_title：Virology

authors： Zhang Z,Kang SM,LeBlanc A,Hajduk SL,Morrow CD

更新日期：1996-12-15 00:00:00

abstract：:We previously described a single-cycle dengue vaccine (RepliVAX D2) engineered from a capsid (C) gene-deleted West Nile virus (WNV) expressing dengue virus serotype 2 (DENV2) prM/E genes in place of the corresponding WNV genes. That work demonstrated that adaptation of RepliVAX D2 to grow in WNV C-expressing cells res...

journal_title：Virology

authors： Winkelmann ER,Widman DG,Suzuki R,Mason PW

更新日期：2011-12-20 00:00:00

abstract：:RNA analysis by nondenaturing polyacrylamide gel electrophoresis and Northern blot hybridization of avocado chloroplasts purified from protoplasts of leaves infected by avocado sunblotch viroid (ASBVd) revealed the main ASBVd-specific bands found previously in preparations of total leaf RNA: the monomeric, dimeric and...

journal_title：Virology

authors： Navarro JA,Darós JA,Flores R

更新日期：1999-01-05 00:00:00

abstract：:Lymphoid cell lines were derived from three avian leukosis virus (ALV)-induced lymphomas. These cell lines contained proviral DNA sequences integrated upstream from the c-myc proto-oncogene, expressed increased levels of c-myc RNA, and were tumorigenic in syngeneic animals. While cell surface immunoglobulin (IgM) was ...

journal_title：Virology

authors： Baba TW,Giroir BP,Humphries EH

更新日期：1985-07-15 00:00:00

abstract：:We evaluated the immunogenicity and protective activity of plasmid DNA vaccines encoding the influenza virus NP gene (pNP) alone or in combination with the herpes simplex virus type 1 protein 22 gene (pVP22). Optimal immune responses were observed in BALB/c mice immunized with the combination of pVP22 plus pNP, as ass...

journal_title：Virology

authors： Saha S,Yoshida S,Ohba K,Matsui K,Matsuda T,Takeshita F,Umeda K,Tamura Y,Okuda K,Klinman D,Xin KQ,Okuda K

更新日期：2006-10-10 00:00:00

abstract：:We test the hypothesis that the translation machinery in cells infected by influenza A virus efficiently translates only mRNAs that possess the influenza viral 5' untranslated region (5'-UTR) by introducing mRNAs directly into the cytoplasm of infected cells. This strategy avoids effects due to the inhibition of the n...

journal_title：Virology

authors： Cassetti MC,Noah DL,Montelione GT,Krug RM

更新日期：2001-10-25 00:00:00

abstract：:Endogenous feline leukemia viruses (enFeLVs) occur in the germ lines of the domestic cat and related wild species (genus Felis). We sequenced the long terminal repeats and part of the env region of enFeLVs in domestic cats and five wild species. A total of 305 enFeLV sequences were generated across 17 individuals, dem...

journal_title：Virology

authors： Polani S,Roca AL,Rosensteel BB,Kolokotronis SO,Bar-Gal GK

更新日期：2010-09-30 00:00:00

abstract：:L83V-related variants of human papillomavirus (HPV) 16 E6, exemplified by the Asian-American variant Q14H/H78Y/L83V, were shown to be more prevalent than E6 prototype in progressing lesions and cervical cancer. We evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as w...

journal_title：Virology

authors： Zehbe I,Richard C,DeCarlo CA,Shai A,Lambert PF,Lichtig H,Tommasino M,Sherman L

更新日期：2009-01-05 00:00:00

abstract：:Nipah virus (NiV) causes severe encephalitis in humans, with high mortality. NiV nonstructural C protein (NiV-C) is essential for its pathogenicity, but its functions are unclear. In this study, we focused on NiV-C trafficking in cells and found that it localizes predominantly in the cytoplasm but partly in the nucleu...

journal_title：Virology

authors： Horie R,Yoneda M,Uchida S,Sato H,Kai C

更新日期：2016-10-01 00:00:00

abstract：:The utilization of transgenic plants expressing recombinant antigens to be used in the formulation of experimental immunogens has been recently communicated. We report here the development of transgenic plants of alfalfa expressing the structural protein VP1 of foot and mouth disease virus (FMDV). The presence of the ...

journal_title：Virology

authors： Wigdorovitz A,Carrillo C,Dus Santos MJ,Trono K,Peralta A,Gómez MC,Ríos RD,Franzone PM,Sadir AM,Escribano JM,Borca MV

更新日期：1999-03-15 00:00:00

abstract：:The differential symptom determinants of the Holmes' masked (M) and U1 strains of tobacco mosaic virus previously were mapped to the 5'-coterminal open reading frame (ORF) encoding the 126-kDa protein and the N-terminal two-thirds of the 183-kDa protein. Both proteins influence viral RNA accumulation, but the function...

journal_title：Virology

authors： Shintaku MH,Carter SA,Bao Y,Nelson RS

更新日期：1996-07-01 00:00:00