DNA binding activity is required for EBNA 1-dependent transcriptional activation and DNA replication.

abstract：:We have applied the procedure of Agrobacterium-mediated inoculation to develop a simple, efficient, and reproducible assay for the infectivity of the leafhopper-transmitted geminivirus, beet curly top virus (BCTV). This assay system was used to show that a coat protein mutant of BCTV is not infectious, but could be co...

journal_title：Virology

authors： Briddon RW,Watts J,Markham PG,Stanley J

更新日期：1989-10-01 00:00:00

abstract：:The efficacy of combining immunization with human immunodeficiency vitus type 1 (HIV-1) DNA and HIV-1 recombinant proteins to obtain protection from chimeric simian/human immunodeficiency virus (SHIV) was determined. Four cynomolgus monkeys received four gene-gun immunizations intraepidermally of plasmid DNA encoding ...

journal_title：Virology

authors： Putkonen P,Quesada-Rolander M,Leandersson AC,Schwartz S,Thorstensson R,Okuda K,Wahren B,Hinkula J

更新日期：1998-10-25 00:00:00

abstract：:The atomic structure of the DNA-containing T = 1 particle of the parvovirus minute virus of mice (MVM) reveals cylindrical projections at each fivefold symmetry axis, each containing an 8 Angstrom pore through which runs 10 amino acids of a single VP2 N-terminus. The tightest constriction of this pore is formed at its...

journal_title：Virology

authors： Farr GA,Tattersall P

更新日期：2004-06-01 00:00:00

abstract：:It is unknown which HIV proteins to target by vaccination in order to generate the most effective CD8 T-cell immunity. We recently immunized SIV(mac251)-infected pigtail macaques with Gag peptides or a cocktail of peptides spanning all SIV proteins, including SIV Env. High-level SIV Env-specific CD8 T-cell responses w...

journal_title：Virology

authors： Peut V,Kent SJ

更新日期：2009-02-05 00:00:00

abstract：:The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, is an acutely pathogenic lentivirus that causes severe gastrointestinal disease in macaque monkeys. The studies reported here examine the basis for the enteropathic phenotype of SIVsmmPBj14, using flow cytometric analysis of cultured macaque lymphocytes ...

journal_title：Virology

authors： Gummuluru S,Novembre FJ,Seshi B,Dewhurst S

更新日期：1996-01-01 00:00:00

abstract：:Brain metastases occur commonly in the setting of a variety of human cancers. At present, such cases are invariably fatal and highlight a need for research on new therapies. We have developed a mouse brain tumor model utilizing the Harding-Passey melanoma cell line injected intracranially into C57Bl/6 mice. Tumors dev...

journal_title：Virology

authors： Randazzo BP,Kesari S,Gesser RM,Alsop D,Ford JC,Brown SM,Maclean A,Fraser NW

更新日期：1995-08-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) establishes lifelong latent infection in sensory neurons of the peripheral nervous system. During HSV latency, the latency-associated transcripts (LATs) are the only viral transcripts abundantly expressed. The most abundant form of LATs is a 2-kb stable intron spliced from a primary...

journal_title：Virology

authors： Mukerjee R,Kang W,Suri V,Fraser NW

更新日期：2004-07-01 00:00:00

abstract：:A human cytomegalovirus (HCMV)-induced polypeptide of 68,000 Da (p68) with protein kinase activity was identified using a monoclonal antibody (F6b) produced against HCMV-infected cell proteins. p68 was detected by immunoprecipitation from 3 to 120 hr after infection and was induced by several strains of human and not ...

journal_title：Virology

authors： Michelson S,Tardy-Panit M,Bârzu O

更新日期：1984-04-30 00:00:00

abstract：:We mutagenized and characterized a 41-kilobase-pair subgenomic cloned fragment from the unique long (UL) region of pseudorabies virus (PRV). Forty mutant clones, each carrying a single inserted oligonucleotide, were used for cotransfection with overlapping cloned viral DNA fragments. More than half of these transfecti...

journal_title：Virology

authors： De Wind N,Peeters BP,Zuderveld A,Gielkens AL,Berns AJ,Kimman TG

更新日期：1994-05-01 00:00:00

abstract：:Poliovirus readily establishes a persistent infection in the K562-Mu erythroleukemia cell strain. In this study, three additional K562 cell strains were analyzed for their responses to poliovirus infection and found to be quite variable. K562 cells obtained from the ATCC established a persistent infection, similar to ...

journal_title：Virology

authors： Benton PA,Murphy JW,Lloyd RE

更新日期：1995-10-20 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells. We and others have shown that EBV can also infect a subset of thymocytes. Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection. Circularization of the EBV genome was not detected. This is in con...

journal_title：Virology

authors： Kelleher CA,Paterson RK,Dreyfus DH,Streib JE,Xu JW,Takase K,Jones JF,Gelfand EW

更新日期：1995-04-20 00:00:00

abstract：:Mixed infections of tobacco protoplasts with Cowpea chlorotic mottle virus (CCMV) and brome mosaic virus (BMV) have been studied. Fluorescent antibody staining showed that capsids of both viruses were made in doubly infected protoplasts but only infectious BMV could be recovered, i.e., BMV dominated in mixed infection...

journal_title：Virology

authors： Watts JW,Dawson JR

更新日期：1980-09-01 00:00:00

abstract：:The 5' untranslated region (5'UTR) of coxsackievirus B3 (CVB3) RNA forms a highly ordered secondary structure that has been implicated in controlling initiation of viral translation by internal ribosomal entry. To test this hypothesis, synthetic bicistronic RNAs, with all or part of the 5'UTR in the intercistronic spa...

journal_title：Virology

authors： Yang D,Wilson JE,Anderson DR,Bohunek L,Cordeiro C,Kandolf R,McManus BM

更新日期：1997-02-03 00:00:00

abstract：:Rice tungro disease is caused by a complex of two viruses, Rice tungro bacilliform virus (RTBV) and Rice tungro spherical virus (RTSV). To examine the RNAi-based defence response in rice during tungro disease, we characterized the virus-derived small RNAs and miRNAs by Deep Sequencing. We found that, while 21 nt/22 nt...

journal_title：Virology

authors： Zarreen F,Kumar G,Johnson AMA,Dasgupta I

更新日期：2018-10-01 00:00:00

abstract：:Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important ...

journal_title：Virology

authors： Carballeda JM,Maroniche G,Lucero MS,Richetta M,Gómez E,Chimeno Zoth S,Berinstein A

更新日期：2015-09-01 00:00:00

abstract：:We previously reported that a mutant of Mason-Pfizer monkey virus (M-PMV), which has an amino acid substitution in the matrix (MA) protein at position 55, MA-R55W, showed altered viral morphogenesis, reduced glycoprotein incorporation, and loss of infectivity. In this report, we show that two additional amino acid sub...

journal_title：Virology

authors： Yasuda J,Hunter E

更新日期：2000-03-15 00:00:00

abstract：:The mechanism and machinery of hepatitis C virus (HCV) RNA replication are still poorly characterized. Our previous study has shown that HCV RNA synthesis occurs on a lipid raft membrane structure [J. Virol. 77 (2003) 77 4160]. In this study, we further characterized these replication complexes (RCs) in Huh-7 cells th...

journal_title：Virology

authors： Aizaki H,Lee KJ,Sung VM,Ishiko H,Lai MM

更新日期：2004-07-01 00:00:00

abstract：:We constructed a sensitive and quantitative assay system to examine human T-cell leukemia virus type I (HTLV-I) envelope (env) glycoprotein-mediated cell fusion in which T7 RNA polymerase in donor cells coexpressing env glycoproteins activates a reporter gene in recipient cells upon cell fusion. An efficient expressio...

journal_title：Virology

authors： Okuma K,Nakamura M,Nakano S,Niho Y,Matsuura Y

更新日期：1999-02-15 00:00:00

abstract：:Extra MMTV proviruses in T-cell leukemias of GR and C57/BL10 mice contain alterations in their long terminal repeat (LTR) sequence. The four different leukemias studied contain different deletions, but common hallmarks were observed around the recombination sites. At the 5' end of the deletions we observed a common no...

journal_title：Virology

authors： Michalides R,Wagenaar E

更新日期：1986-10-15 00:00:00

abstract：:The role of the matrix (MA) domain of simian immunodeficiency virus (SIV) and bovine leukaemia virus (BLV) Gag in the assembly of virus-like particles (VLP) in insect cells has been investigated. Wild-type SIV and BLV Gag assembled to form discrete VLP structures typical of many retroviruses analysed by similar system...

journal_title：Virology

authors： Kakker NK,Mikhailov MV,Jones IM,Roy P

更新日期：2002-07-20 00:00:00

abstract：:When electrophoresed in 0.7% agarose gels, populations of reovirus particles can be resolved into 13 well-defined bands that possess from 0 to 12 projection/spike-associated trimers of protein sigma 1. This state of affairs is not an artifact of purification, of the techniques used to demonstrate it, of aggregation, o...

journal_title：Virology

authors： Larson SM,Antczak JB,Joklik WK

更新日期：1994-06-01 00:00:00

abstract：:Two types of dengue (DEN) 2 virus mutants were selected either by repeated exposure to acidic pH (acid mutant, AM), or by the addition of ammonium chloride to Aedes albopictus C6/36 cells prior to and during viral infection (fusion mutant, FM). Both mutants grew more slowly than the parent strain and induced smaller p...

journal_title：Virology

authors： Guirakhoo F,Hunt AR,Lewis JG,Roehrig JT

更新日期：1993-05-01 00:00:00

abstract：:The red clover necrotic mosaic dianthovirus capsid protein is expressed in vivo from a subgenomic RNA (sgRNA) identical to the 3'-terminal 1.5 kb of RNA-1. The 5' leader sequence of the capsid protein sgRNA is 62 nucleotides, contains a 14-nucleotide putative promoter sequence homologous to the RNA-1 5' terminus, and ...

journal_title：Virology

authors： Zavriev SK,Hickey CM,Lommel SA

更新日期：1996-02-15 00:00:00

abstract：:We have used field inversion gel electrophoresis to survey EBV strains for the size of the major internal repeat, IR-1, and estimate the number of 3.1-kb repeat units present. The B95-8 strain of EBV was estimated to contain 8.6 repeats. The repeat number varies considerably among naturally occurring isolates around a...

journal_title：Virology

authors： Allan GJ,Rowe DT

更新日期：1989-12-01 00:00:00

abstract：:The HIV-1 transframe protein p6 known to modulate HIV-1 protease activation has been suggested to interact with the viral pathogenicity factor Nef. However, a potential interaction site in p6 has not been mapped so far. To evaluate effects of p6 modification on viral replication in light of Nef function, clustered sub...

journal_title：Virology

authors： Leiherer A,Ludwig C,Wagner R

更新日期：2009-04-25 00:00:00

abstract：:Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant (1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A/PR/8/34 nucleoprote...

journal_title：Virology

authors： Townsend AR,Skehel JJ,Taylor PM,Palese P

更新日期：1984-03-01 00:00:00

abstract：:PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis t...

journal_title：Virology

authors： Sommerfelt MA,Harkestad N,Hunter E

更新日期：2003-10-25 00:00:00

abstract：:The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the resp...

journal_title：Virology

authors： Escriou N,Callendret B,Lorin V,Combredet C,Marianneau P,Février M,Tangy F

更新日期：2014-03-01 00:00:00

abstract：:Vaccinia virus (VV) encodes a 37-kDa envelope protein (p37) that is palmitylated on cysteine residues 185186 of the 372-amino acid protein. We have previously reported on a loosely conserved consensus motif. Further analysis has identified a conserved consensus sequence, Hydro*AAC(C)A (Hydro* represents a hydrophobic ...

journal_title：Virology

authors： Hansen SG,Grosenbach DW,Hruby DE

更新日期：1999-02-01 00:00:00

abstract：:Frequent occurrence of woodchuck hepatitis virus DNA (WHV DNA) integration into or in proximity to myc oncogenes and in the win locus of cellular genome in woodchuck hepatocellular carcinomas (HCC) has been described by several authors. We report a further cellular locus as a recurrent target for WHV integration in wo...

journal_title：Virology

authors： Bruni R,Argentini C,D'Ugo E,Giuseppetti R,Ciccaglione AR,Rapicetta M

更新日期：1995-12-01 00:00:00