Abstract:
:The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, is an acutely pathogenic lentivirus that causes severe gastrointestinal disease in macaque monkeys. The studies reported here examine the basis for the enteropathic phenotype of SIVsmmPBj14, using flow cytometric analysis of cultured macaque lymphocytes and immunohistochemical staining of tissue specimens from virus-infected macaques. The data show that enteropathic molecular clones of SIVsmmPBj14 induce expression of the alpha E beta 7 integrin, which is believed to mediate mucosal retention of T-cells, whereas molecular clones from nonenteropathic derivatives of SIVsmmPBj14 do not do so. Thus, elevated expression of alpha E beta 7 may ber responsible, at least in part, for the accumulation of abnormally large numbers of T-cells within the intestinal mucosa during acute SIVsmmPBj14 infection.
journal_name
Virologyjournal_title
Virologyauthors
Gummuluru S,Novembre FJ,Seshi B,Dewhurst Sdoi
10.1006/viro.1996.0010subject
Has Abstractpub_date
1996-01-01 00:00:00pages
97-100issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(96)90010-0journal_volume
215pub_type
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