Human herpesvirus type 8 variants circulating in Europe, Africa and North America in classic, endemic and epidemic Kaposi's sarcoma lesions during pre-AIDS and AIDS era.

abstract：:Interferon gamma (IFNγ) has complex immunomodulatory and antiviral properties. While IFNγ is detected in the airways in response to infection with the pneumovirus pathogen, pneumonia virus of mice (PVM; Family Paramyxoviridae), its role in promoting disease has not been fully explored. Here, we evaluate PVM infection ...

journal_title：Virology

authors： Glineur SF,Bowen AB,Percopo CM,Garcia-Crespo KE,Dyer KD,Ochkur SI,Lee NA,Lee JJ,Domachowske JB,Rosenberg HF

更新日期：2014-11-01 00:00:00

abstract：:The baculovirus-insect cell system is used routinely for foreign glycoprotein production, but the precise nature of the N-glycosylation pathway in this system remains unclear. Some studies indicate that these cells cannot process N-linked oligosaccharides to complex forms containing outer-chain galactose and sialic ac...

journal_title：Virology

authors： Jarvis DL,Finn EE

更新日期：1995-10-01 00:00:00

abstract：:To illuminate the molecular basis for host range restriction of parainfluenza virus replication, we have examined the types of virus macromolecules produced during abortive infection of nonpermissive MDBK cells with human parainfluenza virus type 1 (hPIV1). While these cells do not support production of hPIV1 virus, t...

journal_title：Virology

authors： Tao T,Ryan KW

更新日期：1996-06-01 00:00:00

abstract：:The major capsid protein of HPV, L1, assembles into pentamers that form a T = 7 icosahedral particle, but the location of the co-assembled minor capsid protein, L2, remains controversial. Several researchers have developed useful monoclonal antibodies targeting L2, but most react with linear epitopes toward the N-term...

journal_title：Virology

authors： Bywaters SM,Brendle SA,Biryukov J,Wang JW,Walston J,Milici J,Roden RB,Meyers C,Christensen ND

更新日期：2018-11-01 00:00:00

abstract：:Infection with Epstein-Barr virus (EBV) usually leads to a latent state in B lymphocytes. The virus can be reactivated through two viral transactivators, Zta and Rta, leading to a cascade of gene expression. An EBV DNA array was generated to analyze the pattern of transcription of the entire EBV genome under various c...

journal_title：Virology

authors： Lu CC,Jeng YY,Tsai CH,Liu MY,Yeh SW,Hsu TY,Chen MR

更新日期：2006-02-20 00:00:00

abstract：:The open reading frame of the large subunit (R1) of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase has been positioned downstream of the phage T7 gene 10 promoter in the expression vector, pET. Transformation of this recombinant plasmid into Escherichia coli BL21 DE3 cells containing the T7 RNA polymeras...

journal_title：Virology

authors： Furlong J,Conner J,McLauchlan J,Lankinen H,Galt C,Marsden HS,Clements JB

更新日期：1991-06-01 00:00:00

abstract：:We cloned and sequenced the cDNAs against genomic RNAs and mRNAs for phosphoproteins (Ps) of human parainfluenza virus types 4A (PIV-4A) and 4B (PIV-4B). The PIV-4A and -4B P genes were 1535 nucleotides including poly(A) tract and were found to have two small open reading frames, neither of which was apparently large ...

journal_title：Virology

authors： Kondo K,Bando H,Tsurudome M,Kawano M,Nishio M,Ito Y

更新日期：1990-09-01 00:00:00

abstract：:Condylomata acuminata is caused by human papillomavirus (HPV). PCR with consensus primers will typically detect HPV in >96% of condylomata. Metagenomic sequencing has found that some "HPV-negative" condylomata do indeed contain HPV. We wished to perform a renewed evaluation of the "HPV-negative" condylomata using deep...

journal_title：Virology

authors： Arroyo Mühr LS,Bzhalava D,Lagheden C,Eklund C,Johansson H,Forslund O,Dillner J,Hultin E

更新日期：2015-11-01 00:00:00

abstract：:The failure of HIV-1 to escape at some cytotoxic T-lymphocyte (CTL) epitopes has generally been explained in terms of viral fitness costs or ineffective or attenuated CTL responses. Relatively little attention has been paid to the evolutionary time required for escape mutants to be detected. This time is significantly...

journal_title：Virology

authors： Liu Y,Mullins JI,Mittler JE

更新日期：2006-03-30 00:00:00

abstract：:Influenza virus has a segmented genome composed of eight negative stranded RNA segments. Each segment is covered with NP forming ribonucleoproteins (vRNPs) and carries a copy of the heterotrimeric polymerase complex. As a rare phenomenon among the RNA viruses, the viral replication occurs in the nucleus and therefore ...

journal_title：Virology

authors： Boulo S,Akarsu H,Lotteau V,Müller CW,Ruigrok RW,Baudin F

更新日期：2011-01-05 00:00:00

abstract：:The genus Badnavirus is characterized by members that are genetically and serologically heterogeneous which presents challenges for their detection and characterization. The presence of integrated badnavirus-like sequences in some host species further complicates detection using PCR-based protocols. To address these c...

journal_title：Virology

authors： Sukal AC,Kidanemariam DB,Dale JL,Harding RM,James AP

更新日期：2019-03-01 00:00:00

abstract：:Unusual Plum pox virus (PPV) isolates (named Tat isolates) were discovered on sour cherry (Prunus cerasus) in Russia. They failed to be recognized by RT-PCR using commonly employed primers specific to the strains C or CR (the only ones that proved able to infect sour cherry) as well as to the strains M and W. Some of ...

journal_title：Virology

authors： Chirkov S,Ivanov P,Sheveleva A,Zakubanskiy A,Osipov G

更新日期：2017-02-01 00:00:00

abstract：:Glycoprotein C (gC) of pseudorabies virus, a swine herpesvirus, initiates virus attachment by binding to heparan sulfate (HS) linked to proteoglycans (HSPGs) on the cell surface. This interaction facilitates a required step in virus entry, the binding to a non-HS coreceptor, likely by another viral glycoprotein, gD. W...

journal_title：Virology

authors： Rue CA,Ryan P

更新日期：2003-03-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) Gag proteins are assembled into virus particles and then cleaved by the virion-associated HIV protease. Concomitant with Gag processing, doughnut-like HIV particles (the immature form) are converted to particles containing condensed cores (the mature form). Here we describe the in vi...

journal_title：Virology

authors： Morikawa Y,Shibuya M,Goto T,Sano K

更新日期：2000-07-05 00:00:00

abstract：:Human keratinocytes (HKc) immortalized by human papillomavirus type 16 DNA (HKc/HPV16) progress toward malignancy through growth factor-independent (HKc/GFI) and differentiation-resistant stages (HKc/DR). This progression is associated with a loss of sensitivity to growth inhibition by both all-trans-retinoic acid (RA...

journal_title：Virology

authors： Mi Y,Borger DR,Fernandes PR,Pirisi L,Creek KE

更新日期：2000-05-10 00:00:00

abstract：:A combinatorial, phage-display library of human Fab antibody fragments was generated from IgG heavy chain (HC) and light chain (LC) genes cloned from the lymphocytes of a vaccinia virus (VACV)-immune donor. To ascertain the complexity of the library, nucleotide sequences of the variable regions of the HC and LC genes ...

journal_title：Virology

authors： Schmaljohn C,Cui Y,Kerby S,Pennock D,Spik K

更新日期：1999-05-25 00:00:00

abstract：:A previous study showed that an Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) 25K mutant produced less polyhedrin protein than wild-type (Jarvis et al., J. Virol. 66, 6903-6911, 1992). In this study, the role of the 25K gene product (AcMNPV ORF 61) in baculovirus gene expression was further in...

journal_title：Virology

authors： Harrison RL,Jarvis DL,Summers MD

更新日期：1996-12-01 00:00:00

abstract：:We report the complete nucleotide sequence of the bovine herpesvirus 1 (BHV-1) immediate-early gene encoding BICP4, the homolog of the ICP4 protein of herpes simplex virus. Combined with previous mapping studies, the sequence analysis revealed that the transcript for BICP4 consisted of a noncoding leader RNA (exon 1; ...

journal_title：Virology

authors： Schwyzer M,Vlcek C,Menekse O,Fraefel C,Paces V

更新日期：1993-11-01 00:00:00

abstract：:Deletion of the nef gene results in viral attenuation and confers protection against challenge with wild-type simian immunodeficiency virus in macaques. Regarding HIV-1 infection, a few long-term nonprogressors (LTNP) with nef deletions have been described. In this study, the nef genes of a group of seven LTNP and eig...

journal_title：Virology

authors： Brambilla A,Turchetto L,Gatti A,Bovolenta C,Veglia F,Santagostino E,Gringeri A,Clementi M,Poli G,Bagnarelli P,Vicenzi E

更新日期：1999-07-05 00:00:00

abstract：:By the use of reverse transcription followed by polymerase chain reaction (RT-PCR), we have identified one shorter than full-length, pregenomic viral RNA species in liver samples of woodchucks chronically infected with the woodchuck hepatitis virus (WHV). The spliced WHV RNA of about 2.4 kb in length was cloned and pa...

journal_title：Virology

authors： Hantz O,Baginski I,Fourel I,Chemin I,Trepo C

更新日期：1992-09-01 00:00:00

abstract：:Turnip leaves infected with turnip crinkle virus accumulate a 35-kd polypeptide which comigrates with the major protein from isolated virions. RNA from TCV virions directs the synthesis of a number of polypeptides in vitro including a 35-kd protein which is immunoprecipitable with antiserum to virus particles. Transla...

journal_title：Virology

authors： Altenbach SB,Howell SH

更新日期：1982-04-15 00:00:00

abstract：:Experiments were undertaken to determine if the sera of avian sarcoma virus-infected 15I5 X 7(2) chickens exhibit antibody reactivity for species of endogenous retroviral envelope glycoprotein expressed in 15I5 X 7(2) fibroblasts. Two viruses were used for infection of the 15I5 X 7(2) chickens, Pr-A and cl. 85; the en...

journal_title：Virology

authors： Halpern MS,Deery DT,Flores LJ,Fujita DJ,Mason WS

更新日期：1983-01-30 00:00:00

abstract：:DNA obtained from New Zealand white rabbit oral papillomas was analyzed for the presence of papillomavirus DNA. The viral genome was cloned as three separate subclones, which were each mapped and oriented with respect to one another. Comparisons with other papillomavirus DNAs by Southern blot hybridization under vario...

journal_title：Virology

authors： O'Banion MK,Cialkowski ME,Reichmann ME,Sundberg JP

更新日期：1988-01-01 00:00:00

abstract：:NF-kappaB comprises a family of transcription factors that regulate key immune processes. In this study, the effects of orthopoxvirus infection upon the activation of NF-kappaB were examined. During the early phase of infection, cowpox virus can inhibit the induction of NF-kappaB-regulated gene expression by interferi...

journal_title：Virology

authors： Oie KL,Pickup DJ

更新日期：2001-09-15 00:00:00

abstract：:Marburg virus (MBGV), for which no vaccines or treatments currently exist, causes an acute hemorrhagic fever with a high mortality rate in humans. We previously showed that immunization with either killed MBGV or a glycoprotein (GP) subunit prevented lethal infection in guinea pigs. In the studies reported here, an RN...

journal_title：Virology

authors： Hevey M,Negley D,Pushko P,Smith J,Schmaljohn A

更新日期：1998-11-10 00:00:00

abstract：:Replication and transmission of avian influenza virus in humans poses a pandemic threat. The molecular determinants that facilitate this process are not well understood. We used DBA/2 mice to identify viral factors that mediate the difference in pathogenesis between a virulent (H7N3) and a non-virulent (H7N9) avian in...

journal_title：Virology

authors： DesRochers BL,Chen RE,Gounder AP,Pinto AK,Bricker T,Linton CN,Rogers CD,Williams GD,Webby RJ,Boon AC

更新日期：2016-07-01 00:00:00

abstract：:We have previously shown that the late promoter of the human papovavirus BK (prototype) is contained within the three 68-bp repeats and a 66-bp region to the late side of the repeats which together constitute the early promoter enhancer. We have now carried out unidirectional deletion and linker scan analyses of these...

journal_title：Virology

authors： Cassill JA,Deyerle KL,Subramani S

更新日期：1989-03-01 00:00:00

abstract：:Certain temperature-sensitive (ts) mutants of murine leukemia virus (MuLV) were observed to be defective in virus assembly. These mutants also accumulated intracellular core protein precursor, Pr65gag, at 39 degrees, the nonpermissive temperature. At 39 degrees, virions released from cells infected with the various ts...

journal_title：Virology

authors： Edbauer CA,Naso RB

更新日期：1984-04-30 00:00:00

abstract：:A number of factors that affect genetic interaction during mixed infection with temperature-sensitive mutants of simian rotavirus SA11 have been examined. (1) Statistical analyses of recombination frequency (RF) indicated that (a) the variability noted in RF was not related to variations in experimental conditions and...

journal_title：Virology

authors： Ramig RF

更新日期：1983-05-01 00:00:00

abstract：:The biological phenotype of HIV-1 isolates from 21 subjects with primary HIV-1 infection was determined in primary lymphocytes and monocyte-derived macrophages as well as in three T-cell lines (MT-2, HUT78, and C8166). Seven isolates (33%) replicated on at least one cell line and were classified as rapid/high (n = 6) ...

journal_title：Virology

authors： Fiore JR,Björndal A,Peipke KA,Di Stefano M,Angarano G,Pastore G,Gaines H,Fenyö EM,Albert J

更新日期：1994-10-01 00:00:00