Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates.

abstract：:The 130-kDa bovine herpesvirus-1 (BHV-1) glycoprotein GVP 6 was found to cross-react immunologically with the herpes simplex glycoprotein gB. Antibodies in polyclonal serum against gB immunoprecipitated GVP 6 and its cleavage products from a lysate of BHV-1-infected cells. Conversely, polyclonal serum against GVP 6 pr...

journal_title：Virology

authors： Misra V,Nelson R,Smith M

更新日期：1988-10-01 00:00:00

abstract：:To identify ranavirus virulence genes, we engineered Frog Virus 3 (FV3) knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD) protein (Δ64R-FV3) and a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3). Compared to wild type (WT) FV3, infection of Xenopus tadpo...

journal_title：Virology

authors： Andino Fde J,Grayfer L,Chen G,Chinchar VG,Edholm ES,Robert J

更新日期：2015-11-01 00:00:00

abstract：:Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, deri...

journal_title：Virology

authors： Monteiro JMC,Oliveira MD,Dias RS,Nacif-Marçal L,Feio RN,Ferreira SO,Oliveira LL,Silva CC,Paula SO

更新日期：2018-01-15 00:00:00

abstract：:The monocytoid tumor cell line U-937 and five derived subclones were infected with the HTLV-IIIB isolate of the human immunodeficiency virus (HIV). Susceptibility to infection and sensitivity to the cytopathic effects correlated with the expression of the T4 antigen on the cell surface. On the basis of these character...

journal_title：Virology

authors： Asjö B,Ivhed I,Gidlund M,Fuerstenberg S,Fenyö EM,Nilsson K,Wigzell H

更新日期：1987-04-01 00:00:00

abstract：:Naturally occurring mutations in Human T-cell Leukemia Virus Type 1 (HTLV-1) Tax protein lead to loss of recognition by cytotoxic T-lymphocytes. Most of these mutations also abolish or severely impair the transactivation function of Tax. Ninety percent of the rex gene, which encodes the viral regulator of mRNA splicin...

journal_title：Virology

authors： Smith RE,Niewiesk S,Booth S,Bangham CR,Daenke S

更新日期：1997-10-27 00:00:00

abstract：:NF-kappaB comprises a family of transcription factors that regulate key immune processes. In this study, the effects of orthopoxvirus infection upon the activation of NF-kappaB were examined. During the early phase of infection, cowpox virus can inhibit the induction of NF-kappaB-regulated gene expression by interferi...

journal_title：Virology

authors： Oie KL,Pickup DJ

更新日期：2001-09-15 00:00:00

abstract：:Inbred mice bearing the FV-1n marker when inoculated at birth with an ecotropic murine leukemia virus (WM 1504-E) obtained from wild mice develop a progressive central nervous system (CNS) disease manifested by hindlimb paralysis and incoordination that begins by 6 to 7 weeks of age. Studies of infected SWR/J mice at ...

journal_title：Virology

authors： Oldstone MB,Jensen F,Elder J,Dixon FJ,Lampert PW

更新日期：1983-07-15 00:00:00

abstract：:Ubiquitin C-terminal Hydrolase L1 (UCH-L1) has oncogenic properties and is highly expressed during malignancies. We recently documented that Epstein-Barr virus (EBV) infection induces uch-l1 expression. Here we show that Kaposi's Sarcoma-associated herpesvirus (KSHV) infection induced UCH-L1 expression, via cooperatio...

journal_title：Virology

authors： Bentz GL,Bheda-Malge A,Wang L,Shackelford J,Damania B,Pagano JS

更新日期：2014-01-05 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells. We and others have shown that EBV can also infect a subset of thymocytes. Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection. Circularization of the EBV genome was not detected. This is in con...

journal_title：Virology

authors： Kelleher CA,Paterson RK,Dreyfus DH,Streib JE,Xu JW,Takase K,Jones JF,Gelfand EW

更新日期：1995-04-20 00:00:00

abstract：:The extraordinarily high level of genetic variation of HIV-1 env genes poses a challenge to obtain antibodies that cross-react with multiple subtype Env glycoproteins. To determine if cross-reactive monoclonal antibodies (mAbs) to highly conserved epitopes in HIV-1 envelope glycoproteins can be induced, we immunized m...

journal_title：Virology

authors： Gao F,Scearce RM,Alam SM,Hora B,Xia S,Hohm JE,Parks RJ,Ogburn DF,Tomaras GD,Park E,Lomas WE,Maino VC,Fiscus SA,Cohen MS,Moody MA,Hahn BH,Korber BT,Liao HX,Haynes BF

更新日期：2009-11-10 00:00:00

abstract：:Multiple RNA species which hybridize to a cloned cDNA probe of the turnip crinkle virus satellite RNA (S-TCV) are found both in virions and in plants infected with virus particles containing S-TCV. At least six of these RNAs appear to be multimeric forms of the satellite RNA based on their migration in denaturing gels...

journal_title：Virology

authors： Altenbach SB,Howell SH

更新日期：1984-04-15 00:00:00

abstract：:It is now widely recognized that BPV-1 and less commonly BPV-2 are the causative agents of equine sarcoids. Here we present the generation of equine cell lines harboring BPV-1 genomes and expressing viral genes. These lines have been either explanted from sarcoid biopsies or generated in vitro by transfection of prima...

journal_title：Virology

authors： Yuan ZQ,Gault EA,Gobeil P,Nixon C,Campo MS,Nasir L

更新日期：2008-04-10 00:00:00

abstract：:Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis. To this end, we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. ...

journal_title：Virology

authors： Meissner EG,Duus KM,Gao F,Yu XF,Su L

更新日期：2004-10-10 00:00:00

abstract：:Previous studies have shown that a 558-bp fragment of human cytomegalovirus (CMV) DNA contained within pCM4127 and designated CMV mtr can morphologically transform rodents cells in vitro. By cotransformation with pCM4127 and a plasmid conferring G418 resistance, pSV2neo, morphologically transformed NIH3T3 cell lines w...

journal_title：Virology

authors： Buonaguro FM,McDougall JK,Galloway DA

更新日期：1987-01-01 00:00:00

abstract：:Synthesis of hepadnaviral DNA is dependent upon both the viral DNA polymerase and the viral core protein, the subunit of the nucleocapsids in which viral DNA synthesis takes place. In a study of natural isolates of duck hepatitis B virus (DHBV), we cloned full-length viral genomes from a puna teal. One of the clones f...

journal_title：Virology

authors： Guo H,Aldrich CE,Saputelli J,Xu C,Mason WS

更新日期：2006-09-30 00:00:00

abstract：:B-HIV1, an oligoclone of immortalized cells derived from human peripheral B lymphocytes infected in vitro with the TIIIB isolate of HIV-1, produces low levels of replication-competent HIV when propagated in 1% serum, but increases production > or = 5-fold after phorbol myristate acetate (PMA) exposure. Electron micros...

journal_title：Virology

authors： Laurence J,Grimison B,Rodriguez-Alfageme C,Astrin SM

更新日期：1993-10-01 00:00:00

abstract：:Wild-type vaccinia virus WR strain forms non-fusogenic (F-) large plaques and is hemagglutinin positive (HA+) under normal conditions of virus infection. We have analyzed a collection of spontaneous, highly attenuated mutants of vaccinia virus isolated from persistently infected Friend erythroleukemia cells (E. Paez, ...

journal_title：Virology

authors： Ortiz MA,Paez E

更新日期：1994-01-01 00:00:00

abstract：:The 30K protein of tobacco mosaic virus was recently confirmed to be involved in cell-to-cell movement of the virus. To characterize common structural features of the 30K protein, the nucleotide sequence of the 30K protein gene of cucumber green mottle mosaic virus (CGMMV, a member of the tobamoviruses) RNA has been d...

journal_title：Virology

authors： Saito T,Imai Y,Meshi T,Okada Y

更新日期：1988-12-01 00:00:00

abstract：:It is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential "transmission signatures", we compared 20 full-length HIV-1 subtype C genomes from primary infections, with 66 sampled from ethnically and geog...

journal_title：Virology

authors： Treurnicht FK,Seoighe C,Martin DP,Wood N,Abrahams MR,Rosa Dde A,Bredell H,Woodman Z,Hide W,Mlisana K,Karim SA,Gray CM,Williamson C

更新日期：2010-01-20 00:00:00

abstract：:Transcription of human papillomaviruses (HPV) is regulated by enhancer sequences located in the upstream regulatory region. The factors regulating expression of one of the high risk genital HPV types, HPV 31b, were investigated using transient expression and protein binding assays. A region of 262 base pairs in length...

journal_title：Virology

authors： Kyo S,Tam A,Laimins LA

更新日期：1995-08-01 00:00:00

abstract：:A recombinant vaccinia virus that expresses the nucleoprotein gene of Lassa virus (Josiah strain) under the control of the P7.5 promoter was constructed using the lacZ coexpression transfer vector pSC11. Southern blot analysis demonstrated that recombination of the sequences inserted within the thymidine kinase gene o...

journal_title：Virology

authors： Morrison HG,Bauer SP,Lange JV,Esposito JJ,McCormick JB,Auperin DD

更新日期：1989-07-01 00:00:00

abstract：:The lentivirus caprine arthritis-encephalitis virus (CAEV) is closely related by nucleotide sequence homology to visna virus and other sheep lentiviruses and shows less similarity to the other animal and human lentiviruses. The genomic organization of CAEV is very similar to that of visna virus and the South African o...

journal_title：Virology

authors： Saltarelli M,Querat G,Konings DA,Vigne R,Clements JE

更新日期：1990-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) encodes a transacting protein, Rev, which interacts with an RNA element (RRE) to mediate nuclear export of unspliced viral mRNA. Recently, the RNA constitutive transport elements (CTE) from Mason-Pfizer monkey virus (MPMV) and simian retrovirus type I (SRV-1) were shown to render Rev...

journal_title：Virology

authors： Tang H,Xu Y,Wong-Staal F

更新日期：1997-02-17 00:00:00

abstract：:HIV-1 virus entry into target cells requires the envelope glycoprotein (Env) to first bind the primary receptor, CD4 and subsequently the co-receptor. Antibody access to the co-receptor binding site (CoRbs) in the pre-receptor-engaged state, prior to cell attachment, remains poorly understood. Here, we have demonstrat...

journal_title：Virology

authors： Boliar S,Patil S,Shukla BN,Ghobbeh A,Deshpande S,Chen W,Guenaga J,Dimitrov DS,Wyatt RT,Chakrabarti BK

更新日期：2018-06-01 00:00:00

abstract：:An infectious raccoon poxvirus (RCNV) was used to express the feline panleukopenia virus (FPV) open reading frame VP2. The recombinant, RCNV/FPV, was constructed by homologous recombination with a chimeric plasmid for inserting the expression cassette into the thymidine kinase (TK) locus of RCNV. Expression of the VP2...

journal_title：Virology

authors： Hu L,Esposito JJ,Scott FW

更新日期：1996-04-01 00:00:00

abstract：:Fiber and penton base overproduced in adenovirus (Ad) infected cells can be secreted prior to progeny release and thereby regulate progeny spread. We aimed to investigate the mechanisms of fiber and penton base secretion in Ad2- or Ad5-infected A549 cells. Our flow cytometry analyses detected abundant surface fiber mo...

journal_title：Virology

authors： Yan Y,Zhang B,Hou W,Lin H,Rebetz J,Hong SS,Wang Y,Ran L,Fan X

更新日期：2017-05-01 00:00:00

abstract：:Selection of high-growth virus variants of strain B/Victoria/504/2000 by serial passage in eggs resulted in three amino acid substitutions, G141E, R162M, and D196Y, in the vicinity of the receptor-binding pocket of viral hemagglutinin. Virus variants containing the identified amino acid substitutions, individually or ...

journal_title：Virology

authors： Lugovtsev VY,Smith DF,Weir JP

更新日期：2009-11-25 00:00:00

abstract：:We have used field inversion gel electrophoresis to survey EBV strains for the size of the major internal repeat, IR-1, and estimate the number of 3.1-kb repeat units present. The B95-8 strain of EBV was estimated to contain 8.6 repeats. The repeat number varies considerably among naturally occurring isolates around a...

journal_title：Virology

authors： Allan GJ,Rowe DT

更新日期：1989-12-01 00:00:00

abstract：:An essentially complete DNA copy of the ambisense S RNA species of Punta Toro (PT) phlebovirus (T. Ihara, H. Akashi, and D.H.L. Bishop, 1984, Virology 136, 293-306) has been inserted in either orientation into Autographa californica nuclear polyhedrosis baculovirus (AcNPV) in lieu of the 5' coding region of the AcNPV ...

journal_title：Virology

authors： Overton HA,Ihara T,Bishop DH

更新日期：1987-04-01 00:00:00

abstract：:Recombinant RNAs generated in plants 3 weeks postinoculation with turnip crinkle virus (TCV) genomic RNA and an associated satellite RNA, sat-RNA D, have a majority of TCV crossover sites in a 24-nucleotide repeat (motif IIIA/IIIB) that forms part of a stable hairpin (Carpenter et al., 1995, J. Mol.Biol. 245, 608-622)...

journal_title：Virology

authors： Carpenter CD,Simon AE

更新日期：1996-09-01 00:00:00