Abstract:
:Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, derived from the secretion of the anuran Hypsiboas semilineatus, has been evaluated. The assays of neutralization in the Vero cells show a complete inhibition of infection of the serotypes 2 and 3. Furthermore, the direct action of peptides on the viral particle can be observed through atomic force microscopy. In vivo tests display 80% protection against the dengue-2 virus due to the presence of HS-1, which reveals its potential as an antiviral against the DENV.
journal_name
Virologyjournal_title
Virologyauthors
Monteiro JMC,Oliveira MD,Dias RS,Nacif-Marçal L,Feio RN,Ferreira SO,Oliveira LL,Silva CC,Paula SOdoi
10.1016/j.virol.2017.11.009subject
Has Abstractpub_date
2018-01-15 00:00:00pages
79-87eissn
0042-6822issn
1096-0341pii
S0042-6822(17)30381-1journal_volume
514pub_type
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