Abstract:
:Simian virus (SV40) T antigen shares many characteristics with adenovirus E1A which is known to induce apoptosis. To verify the potential of SV40 T antigen-mediated apoptosis, we stably expressed T antigen in immortalized human epithelial cells (Z172 and HaCaT). We found that SV40 T antigen could directly cause apoptosis in 22-27% of these cells under normal growth condition as measured by chromatin condensation and nucleosomal fragmentation. The apoptosis of HaCaT cells which contain mutant p53 suggests the p53-independent nature of T antigen-mediated apoptosis. T antigen-induced apoptosis was associated with increased expression of c-Jun protein. Moreover, the overexpression of c-jun alone in these cells also induced apoptosis, indicating that c-jun might play an important role in T antigen-induced apoptosis.
journal_name
Virologyjournal_title
Virologyauthors
Chen SL,Tsao YP,Chen YL,Huang SJ,Chang JL,Wu SFdoi
10.1006/viro.1998.9109subject
Has Abstractpub_date
1998-05-10 00:00:00pages
521-9issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(98)99109-7journal_volume
244pub_type
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