Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis.

abstract：:The Nef protein of Simian immunodeficiency virus (SIV) associates with multiple T lymphocyte signaling proteins, including the T cell receptor (TCR) zeta chain. We demonstrate here that these interactions are conserved and highly specific. Nefs derived from genetically diverse strains of SIV (SIV(mac)239, SIV(smm)PBj,...

journal_title：Virology

authors： Schaefer TM,Bell I,Pfeifer ME,Ghosh M,Trible RP,Fuller CL,Ashman C,Reinhart TA

更新日期：2002-10-10 00:00:00

abstract：:In a previous study on the replication of Kunjin virus using immunoelectron microscopy (E. G. Westaway, J. M. Mackenzie, M. T. Kenney, M. K. Jones, and A. A. Khromykh, 1997, J. Virol. 71, 6650-6661), NS1 and NS3 were found associated with double-stranded RNA (dsRNA) within vesicle packets (VP) in infected Vero cells, ...

journal_title：Virology

authors： Mackenzie JM,Khromykh AA,Jones MK,Westaway EG

更新日期：1998-06-05 00:00:00

abstract：:The protein content of vaccinia virus mature virions, purified by rate zonal and isopycnic centrifugations and solubilized by SDS or a solution of urea and thiourea, was determined by the accurate mass and time tag technology which uses both tandem mass spectrometry and Fourier transform-ion cyclotron resonance mass s...

journal_title：Virology

authors： Resch W,Hixson KK,Moore RJ,Lipton MS,Moss B

更新日期：2007-02-05 00:00:00

abstract：:We have previously described a revertant cell line which expresses a dominant tumor suppressor phenotype to E1 but not to heterologous oncogenes such as c-myc, N-ras, or polyoma middle t (Sircar et al. (1988) Oncogene 3, 725-728). DNA tumor virus oncogenes have been suggested to transform cells via the common mechanis...

journal_title：Virology

authors： Sircar S,Horvath J,Roberge D,Diouri M,Weber JM

更新日期：1992-11-01 00:00:00

abstract：:In addition to its role in virus assembly, the matrix (M) protein of vesicular stomatitis virus (VSV) is involved in virus-induced cell rounding and inhibition of host-directed gene expression. Previous experiments have shown that two M protein mutants genetically dissociate the ability of M protein to inhibit host-di...

journal_title：Virology

authors： Lyles DS,McKenzie MO

更新日期：1997-03-03 00:00:00

abstract：:Guinea pig cytomegalovirus (GPCMV) provides a useful model for studies of congenital CMV infection. During characterization of the GPCMV genome sequence, we identified two types of strains in a virus stock purchased from ATCC. One of them, GPCMV/del, lacks a 1.6 kb locus that positionally corresponds to murine CMV (MC...

journal_title：Virology

authors： Nozawa N,Yamamoto Y,Fukui Y,Katano H,Tsutsui Y,Sato Y,Yamada S,Inami Y,Nakamura K,Yokoi M,Kurane I,Inoue N

更新日期：2008-09-15 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) infection induces changes to the host cell nucleus including relocalization of the cellular protein Upstream Binding Factor (UBF) from the nucleolus to viral replication compartments (VRCs). Herein, we tested the hypothesis that UBF is recruited to VRCs to promote viral DNA replication. ...

journal_title：Virology

authors： Ouellet Lavallée G,Pearson A

更新日期：2015-09-01 00:00:00

abstract：:The envelope (E) protein of dengue virus (DENV) is composed of three domains (EDI, EDII, EDIII) and is the main target of neutralizing antibodies. Many monoclonal antibodies that bind EDIII strongly neutralize DENV. However in vitro studies indicate that anti-EDIII antibodies contribute little to the neutralizing pote...

journal_title：Virology

authors： Williams KL,Wahala WM,Orozco S,de Silva AM,Harris E

更新日期：2012-07-20 00:00:00

abstract：:Bovine immunodeficiency-like virus (BIV) is a recently identified lentivirus that infects cattle. The virus has structural and genetic similarities to human HIV. The present study demonstrates that BIV can be activated by bovine herpesvirus type 1 (BHV-1), a pathogen frequently associated with cattle diseases. Activat...

journal_title：Virology

authors： Geng Y,Kashanchi F,Wood C

更新日期：1992-04-01 00:00:00

abstract：:In this article we report the initial biochemical, genetic, and electron microscopic analysis of a previously uncharacterized, 8.9-kDa, predicted thiol-redox protein. The name A2.5L was assigned to the corresponding vaccinia virus gene, which is conserved in all sequenced poxviruses. Multiple alignment analysis and se...

journal_title：Virology

authors： Senkevich TG,White CL,Weisberg A,Granek JA,Wolffe EJ,Koonin EV,Moss B

更新日期：2002-09-01 00:00:00

abstract：:In a previous paper (G. Winkler, V. B. Randolph, G. R. Cleaves, T. E. Ryan, and V. Stollar, 1988, Virology 162, 187-196) we showed that the newly synthesized dengue-2 virus nonstructural protein, NS1, exists briefly as a monomer and then undergoes dimerization. We demonstrate here that the dimerization of NS1 is assoc...

journal_title：Virology

authors： Winkler G,Maxwell SE,Ruemmler C,Stollar V

更新日期：1989-07-01 00:00:00

abstract：:The growth of vesicular stomatitis virus requires two distinct RNA synthetic events: transcription of messenger RNA molecules and replication of the viral genome RNA. We report the use of a panel of monoclonal antibodies directed against the viral phosphoprotein P in an attempt to assess the role of this protein in RN...

journal_title：Virology

authors： Richardson JC,Peluso RW

更新日期：1996-02-01 00:00:00

abstract：:The rep gene of the defective human parvovirus, adeno-associated virus, (AAV) mediates several trans-acting functions important to virus replication, transcription, and gene expression. At least four overlapping polypeptides are expressed from the rep gene. We have constructed a prokaryotic vector which expressed in E...

journal_title：Virology

authors： Trempe JP,Mendelson E,Carter BJ

更新日期：1987-11-01 00:00:00

abstract：:Structure-guided approaches to HIV-1 vaccine design depend on knowledge of the presentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAb b12. Here, we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, ...

journal_title：Virology

authors： Sterjovski J,Churchill MJ,Ellett A,Wesselingh SL,Ramsland PA,Gorry PR

更新日期：2012-10-25 00:00:00

abstract：:Activation of the human cytomegalovirus (HCMV) origin of replication (oriLyt) was previously demonstrated in transient transfection assays in permissive human fetal fibroblasts and nonpermissive Vero cells, and shown to require six viral proteins that function at the replication fork plus a number of HCMV products tha...

journal_title：Virology

authors： Reid GG,Ellsmore V,Stow ND

更新日期：2003-04-10 00:00:00

abstract：:Camelpox virus (CMLV), a member of the Orthopoxvirus genus in the Poxviridae, is the etiologic agent of a disease of camels. Here we report the CMLV genomic sequence with analysis. The 205,719-bp CMLV genome contains 211 putative genes and consists of a central region bound by identical inverted terminal repeats of ap...

journal_title：Virology

authors： Afonso CL,Tulman ER,Lu Z,Zsak L,Sandybaev NT,Kerembekova UZ,Zaitsev VL,Kutish GF,Rock DL

更新日期：2002-03-30 00:00:00

abstract：:HTLV-I infection is characterized by low viremia and restricted viral expression. While the mechanisms regulating viral latency are poorly understood, it is believed that interactions between viral and host cellular factor(s) are involved. Several lines of evidence indicate that HTLV-I provirus may be methylated in pr...

journal_title：Virology

authors： Saggioro D,Forino M,Chieco-Bianchi L

更新日期：1991-05-01 00:00:00

abstract：:The major outer capsid protein, VP5, of five US bluetongue viruses, was found to be glycosylated. Enzymatic removal of the carbohydrate moiety did not affect the electrophoretic mobility of VP5 in SDS-PAGE, indicating the presence of only short and possibly unbranched oligosaccharide chains. The surface accessibilitie...

journal_title：Virology

authors： Yang YY,Li JK

更新日期：1993-05-01 00:00:00

abstract：:The potential role(s) of cytokines in the reduction of infectious virus and persistent viral infection in the central nervous system was examined by determining the kinetics of cytokine mRNA expression following infection with the neurotropic JHM strain of mouse hepatitis virus. Mice were infected with an antibody esc...

journal_title：Virology

authors： Parra B,Hinton DR,Lin MT,Cua DJ,Stohlman SA

更新日期：1997-07-07 00:00:00

abstract：:Very fast sedimenting DNA (VFS DNA) of T4 phage, which is formed by infection with a mutant in gene 49, was examined by electron microscopy after mild treatment with DNase I. It showed Y-shaped, branched strands in addition to linear strands. Each branch contained a single-stranded interruption about 60 nucleotides lo...

journal_title：Virology

authors： Minagawa T,Murakami A,Ryo Y,Yamagishi H

更新日期：1983-04-15 00:00:00

abstract：:The spread of HIV-1 to the nervous system occurs early during infection in a large number of asymptomatic virus carriers. In order to address the question whether the brain is targeted by a group of HIV-1 variants with increased neurotropic properties we have obtained 20 paired isolates from the blood and cerebrospina...

journal_title：Virology

authors： Keys B,Karis J,Fadeel B,Valentin A,Norkrans G,Hagberg L,Chiodi F

更新日期：1993-10-01 00:00:00

abstract：:Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study, we successfully expressed FcaPV2 E6 and E7 putative oncogenes in feline epithelial cells and demonstrated that FcaPV2 E6 binds to p53...

journal_title：Virology

authors： Altamura G,Corteggio A,Pacini L,Conte A,Pierantoni GM,Tommasino M,Accardi R,Borzacchiello G

更新日期：2016-09-01 00:00:00

abstract：:An SH3-binding domain within the Nef protein of primate lentiviruses has been reported to be important to viral replication and infectivity and dispensable for CD4 downregulation, but its precise role remains unclear. This study investigates the effects of mutations in both the polyproline helix and in the hydrophobic...

journal_title：Virology

authors： Craig HM,Pandori MW,Riggs NL,Richman DD,Guatelli JC

更新日期：1999-09-15 00:00:00

abstract：:Expression of the SV40 large T-antigen allows primary cells to escape senescence and thereby become immortalized. Immortalization occurs in two steps, extension of life span and acquisition of unlimited cell division potential. By following the increase in expression of a senescence-associated marker with increased ce...

journal_title：Virology

authors： Tevethia MJ,Lacko HA,Conn A

更新日期：1998-04-10 00:00:00

abstract：:The mouse mammary tumor virus (MMTV) is a type B retrovirus that is unique from other retroviruses in having multiple "tissue specific" and "hormone inducible" promoters. This unique feature has lead to the increasing interest in studying the biology of MMTV replication with the ultimate goal of developing MMTV based ...

journal_title：Virology

authors： Rizvi TA,Ali J,Phillip PS,Ghazawi A,Jayanth P,Mustafa F

更新日期：2009-03-15 00:00:00

abstract：:The budded form of Autographa californica nuclear polyhedrosis virus functionally enters cells by adsorptive endocytosis. During the period of virus uptake into Spodoptera frugiperda IPLB Sf21 cells (1 to 4 hr postinfection), filamentous F-actin cables, visualized by fluorescence microscopy, were formed within the cyt...

journal_title：Virology

authors： Charlton CA,Volkman LE

更新日期：1993-11-01 00:00:00

abstract：:Measles virus (MV) inhibits lymphocyte function in patients, as well as in cells infected in vitro. The proliferation of phytohemagglutinin-stimulated T lymphocytes is suppressed by in vitro MV infection, as shown by the diminished incorporation of [3H]thymidine into DNA and the reduced frequency of cells in the S pha...

journal_title：Virology

authors： Yanagi Y,Cubitt BA,Oldstone MB

更新日期：1992-03-01 00:00:00

abstract：:The coat protein (CP) of alfalfa mosaic virus (AMV) strain 425 assembles to bacilliform or rod-shaped particles in the presence of nucleic acids or to T = 1 empty icosahedral particles in the absence of nucleic acids. To study the determinants of CP assembly, recombinant CPs (rCPs) that contained a (His)(6) region wer...

journal_title：Virology

authors： Choi J,Loesch-Fries LS

更新日期：1999-07-20 00:00:00

abstract：:The virion-associated Vpr protein of human immunodeficiency virus type 1 (HIV-1) alters cell cycle progression from the G2 phase, influences the virus in vivo mutation rate, and participates in the nuclear translocation of viral DNA. While many Vpr-interacting proteins have been identified, the functional relevance of...

journal_title：Virology

authors： Mansky LM,Preveral S,Le Rouzic E,Bernard LC,Selig L,Depienne C,Benarous R,Benichou S

更新日期：2001-03-30 00:00:00

abstract：:Two bipartite begomoviruses, Indian cassava mosaic virus (ICMV) and Sri Lankan cassava mosaic virus (SLCMV), have been isolated from mosaic-diseased cassava originating from central India and Sri Lanka, respectively. ICMV was transmitted with low efficiency from cassava to Nicotiana benthamiana by sap inoculation to g...

journal_title：Virology

authors： Saunders K,Salim N,Mali VR,Malathi VG,Briddon R,Markham PG,Stanley J

更新日期：2002-02-01 00:00:00