Abstract：
:Coxsackievirus A16 (CAV16) a member of the Enterovirus genus of Picornaviridae, is associated with hand-foot-and-mouth disease, a febrile papulovesicular rash of childhood. We have determined the complete nucleotide sequence of the genome of the prototype strain of CAV16 which consists of 7413 nucleotides plus the poly(A) tail. Alignment of the sequence with the previously studied enteroviruses showed that the genome organization is typical for a member of this virus genus. However, the predicted amino acid sequence of individual CAV16 proteins differed from those of all previously sequenced enteroviruses by 25-62%. The genomic sequence of CAV2 in the capsid and 2A polypeptide regions was also determined. It was found to differ from that of CAV16 by no more than 5-43%. The partial nucleotide sequence of enterovirus 71 in the VP1-2A region suggested that it is also closely related to CAV16. The results indicate that CAV16, CAV2, and enterovirus 71 represent a distinct genetic group of enteroviruses.
journal_name
Virologyjournal_title
Virologyauthors
Pöyry T,Hyypiä T,Horsnell C,Kinnunen L,Hovi T,Stanway Gdoi
10.1006/viro.1994.1423subject
Has Abstractpub_date
1994-08-01 00:00:00pages
982-7issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(84)71423-1journal_volume
202pub_type
杂志文章相关文献
VIROLOGY文献大全abstract：:Disruption of the perforin gene results in primary immunodeficiency and an increased susceptibility to opportunistic pathogens. Perforin-deficient (PKO) mice fail to clear primary lymphocytic choriomeningitis virus (LCMV) Armstrong, resulting in persistent infection and functional exhaustion of virus-specific CD8+ T c...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2007.08.038
更新日期：2008-01-20 00:00:00
abstract：:The management of hand-foot-and-mouth disease(HFMD) epidemic is difficult due to the frequent emergence of non-EV71 and non-CVA16 enteroviruses and some cases testing negative for HFMD-associated causative agents. To clarify the virus spectrum of mild and severe HFMD, a comprehensive virome analysis of 238 samples was...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2018.02.004
更新日期：2018-05-01 00:00:00
abstract：:To investigate the role of Tobacco vein banding mosaic virus (TVBMV) 3'-UTR in virus systemic infection, three types of deletions were introduced into TVBMV infectious clone pCaTVBMV-GFP. Mutants with deletions at the nucleotide position 8-42, 43-141, or 163-174 in the 3'-UTR failed to cause systemic infection in N. b...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2018.11.001
更新日期：2019-01-15 00:00:00
abstract：:Nineteen independent temperature-sensitive (ts) mutants were isolated from SA11 following mutagenesis with proflavin or 5-azacytidine. Fourteen of the ts mutants fell into one or another of five mutant groups previously defined by recombination. Five of the ts mutants defined five recombination groups (F, G, H, I, and...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(83)90100-9
更新日期：1983-10-30 00:00:00
abstract：:The X protein (pX) of hepatitis B virus (HBV) is a general transcription regulator and directly associated with the transcription machinery. pX cannot bind DNA directly but interacts with cellular factors that bind the regulatory elements. There is an accumulation of evidence concerning different activities exerted by...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1994.1356
更新日期：1994-07-01 00:00:00
abstract：:Adenovirus inundates the productively infected cell with linear, double-stranded DNA and an abundance of single-stranded DNA. The cellular response to this stimulus is antagonized by the adenoviral E1B and E4 early genes. A mutant group C adenovirus that fails to express the E1B-55K and E4orf3 genes is unable to suppr...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2014.03.010
更新日期：2014-05-01 00:00:00
abstract：:Vesicular stomatitis virus (VSV) isolated from two independently established lines of persistently infected mouse L cells expressed an altered phenotype of RNA synthesis at 37 degrees, the temperature at which the persistently infected cultures were maintained (T.K. Frey and J.S. Youngner, 1982, J. Virol. 44, 167-174)...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(84)90260-5
更新日期：1984-07-15 00:00:00
abstract：:In vitro, the coat protein of brome mosaic virus (BMV) inhibited RNA synthesis by replicase extracted from BMV-infected barley leaves. The inhibition was due to the interaction of coat protein with BMV RNA. Under the same conditions, no inhibition by TMV coat protein or bovine serum albumin was detected. For the compl...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(87)90232-7
更新日期：1987-05-01 00:00:00
abstract：:Phosphorylation of I kappa Bs--the cytoplasmic inhibitors of the NF-kappa B transcription factors--is the key event which triggers activation of the NF-kappa B cascade. Signal-mediated phosphorylation of I kappa B alpha is mediated by a multiprotein complex, the I kappa B kinase (IKK) complex, which is composed of at ...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.2001.0999
更新日期：2001-08-01 00:00:00
abstract：:The display of foreign proteins on the surface of baculovirus virions has provided a tool for the analysis of protein-protein interactions and for cell-specific targeting in gene transfer applications. To evaluate the baculovirus display system as a vaccine vehicle, we have generated a recombinant baculovirus (AcNPV-C...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2003.08.003
更新日期：2003-11-10 00:00:00
abstract：:The adenine DNA methyltransferase M.CviRI (TGCmA) gene from chlorella virus XZ-6E was cloned into the Autographa californica nuclear polyhedrosis virus (AcMNPV) genome and expressed in Spodoptera frugiperda insect cells under the control of two tandemly arranged viral promoters, the early ETL promoter and the late pol...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1993.1539
更新日期：1993-10-01 00:00:00
abstract：:Replication and transmission of avian influenza virus in humans poses a pandemic threat. The molecular determinants that facilitate this process are not well understood. We used DBA/2 mice to identify viral factors that mediate the difference in pathogenesis between a virulent (H7N3) and a non-virulent (H7N9) avian in...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2016.04.013
更新日期：2016-07-01 00:00:00
abstract：:Astrocytes protect neurons but also evoke a proinflammatory response to injury and viral infections including HIV. We investigated the mechanism of HIV-1 infection in primary astrocytes, which showed minimal but productive viral infection independent of CXCR4. As with ectopic-CD4-expressing astrocytes, lysosomotropic ...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2014.03.002
更新日期：2014-05-01 00:00:00
abstract：:Although replication-incompetent herpes simplex virus (HSV) vectors have the capability to express foreign genes, successful development of these vectors for gene delivery would require that expression of the foreign gene be regulated. To investigate the feasibility of obtaining inducible expression of a foreign gene ...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1996.0635
更新日期：1996-12-01 00:00:00
abstract：:The genetic diversity of group M HIV-1 is highest in west central Africa. Blood samples from four locations in Cameroon were collected to determine the molecular epidemiology of HIV-1. The C2-V5 region of envelope was sequenced from 39 of the 40 samples collected, and 7 samples were sequenced across the genome. All st...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.2001.0976
更新日期：2001-07-20 00:00:00
abstract：:Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2015.02.042
更新日期：2015-07-01 00:00:00
abstract：:In this study, we confirmed the autophagy induced by porcine reproductive and respiratory syndrome virus (PRRSV) in permissive cells and investigated the role of autophagy in the replication of PRRSV. We first demonstrated that PRRSV infection significantly results in the increased double-membrane vesicles, the accumu...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2012.03.022
更新日期：2012-08-01 00:00:00
abstract：:The transmembrane envelope (TM) proteins of retroviruses are used as antigen in diagnostic immunoassays and they represent a conserved target for neutralizing antibodies. To analyze the situation in infections with the feline foamy virus (FFV), its recombinant TM protein was produced and used for ELISA and Western blo...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2011.01.023
更新日期：2011-04-10 00:00:00
abstract：:The complete sequence of the genome of the cherry strain of tomato bushy stunt virus (TBSV), a member of the tombusvirus group, was determined. A full-length clone of the genome containing a bacteriophage T7 RNA polymerase promoter was assembled from partial cDNA clones. In vitro transcripts of the genome, either with...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(90)90468-7
更新日期：1990-07-01 00:00:00
abstract：:Hepatitis C virus (HCV) NS5A is a phosphoprotein that possesses a cryptic trans-activation activity. To investigate its potential role in viral replication, we searched for the cellular proteins interacting with NS5A protein by yeast two-hybrid screening of a human hepatocyte cDNA library. We identified a newly discov...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1999.9893
更新日期：1999-10-10 00:00:00
abstract：:Human cytomegalovirus (HCMV) infects the chorioamnion, but whether these infections cause fetal membrane dysfunction remains poorly understood. We sought to assess whether guinea pig cytomegalovirus (GPCMV) infects amnion-derived cells in vitro, compare the inflammatory response of amnion cells to GPCMV and HCMV, and ...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2020.06.005
更新日期：2020-09-01 00:00:00
abstract：:The human papillomavirus type 16 E1--E4 protein is expressed abundantly in cells supporting viral DNA amplification, but its expression is lost during malignant progression. In cell culture, 16E1--E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. Here, we ...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2006.02.024
更新日期：2006-05-25 00:00:00
abstract：:Human adenovirus type 3 (HAdV-B3) has an apparently stable genome yet remains a major circulating and problematic respiratory pathogen. Comparisons of the prototype genome to genomes from three current field strains, including two isolated from epidemics, and a laboratory strain, yielded small-scale nucleotide variati...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2009.10.052
更新日期：2010-02-05 00:00:00
abstract：:From two human brain tumors SV40 genomes were isolated by recombinant DNA techniques. The SV40 genome cloned from a human meningioma DNA was shown to be indistinguishable from wild-type SV40. In contrast, the SV40 genome cloned from a human astrocytoma proved to be a nonviable deletion mutant with a truncated early re...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(84)90357-x
更新日期：1984-10-30 00:00:00
abstract：:A stem-loop structure, formed by a pair of inverted repeats during DNA replication, is a conserved feature at the origin of DNA replication among plant and animal viruses, bacteriophages and plasmids that replicate their genomes via the rolling-circle replication (RCR) mechanism. In this work, a head-to-tail tandem co...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2007.01.017
更新日期：2007-06-20 00:00:00
abstract：:Flavivirus infection as dengue and yellow fever persists as a terrible menace to pandemics, due to Aedes prevalence in the Americas. Yellow fever is characterized by hepatocyte damage, with steatosis, apoptosis and necrosis, mainly in the midzonal region of the liver, but the injury mechanism has not been studied at t...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2005.09.058
更新日期：2006-02-05 00:00:00
abstract：:The transcriptive complex, the nucleocapsid with the viral RNA-synthesizing activity, of Newcastle disease virus (NDV) contains three protein components, the major structural subunit (NP) and two associated proteins (P and L) involved in the RNA synthesis. We studied the pathway of these proteins from synthesis to ass...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(85)90132-1
更新日期：1985-12-01 00:00:00
abstract：:Equine infectious anemia virus (EIAV) is responsible of acute disease episodes characterized by fever, anemia, thrombocytopenia and anorexia in equids. The high mutation rate in EIAV genome limited the number of full genome sequences availability. In the present study, we used the SureSelect target enrichment system w...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2019.08.016
更新日期：2019-11-01 00:00:00
abstract：:Gp110 of Epstein-Barr virus (EBV) mainly localizes on nuclear/ER membranes and plays a role in the assembly of EBV nucleocapsid. The C-terminal tail domain (gp110 CTD) is essential for the function of gp110 and the nuclear/ER membranes localization of gp110 is ruled by its C-terminal unique nuclear localization signal...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2008.06.031
更新日期：2008-09-30 00:00:00
abstract：:The genome of the Chilo iridescent virus (CIV) was analyzed for existence of repetitive DNA sequences by DNA-DNA hybridization using a defined and complete gene library of the viral genome (209 kbp) and by heteroduplex mapping. These experiments revealed the presence of repetitive DNA elements in the CIV genome, which...
journal_title：Virology
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
