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A model system for regulation of chronic HIV-1 infection in peripheral B lymphocytes.

Abstract：

:B-HIV1, an oligoclone of immortalized cells derived from human peripheral B lymphocytes infected in vitro with the TIIIB isolate of HIV-1, produces low levels of replication-competent HIV when propagated in 1% serum, but increases production > or = 5-fold after phorbol myristate acetate (PMA) exposure. Electron microscopy reveals budding of mature virions from the plasma membrane, without concentration in endocytotic spaces. The PMA effect is specific for protein kinase activation, occurring upon exposure of B-HIV1 to those congeners capable of upregulating calcium and phospholipid dependent protein kinase C and susceptible to inhibition by the protein kinase antagonists H-7 and staurosporine. Induction could also be effected by another viral activator, 5-azacytidine, which acts via an alternate mechanism, and blocked by high doses of interferon-alpha but not the anti-viral nucleoside analog zidovudine (AZT). B-HIV1 may provide a model system for study of the regulation of chronic HIV infection in cells of B lymphocyte lineage.

journal_name

Virology

journal_title

Virology

authors

Laurence J,Grimison B,Rodriguez-Alfageme C,Astrin SM

doi

10.1006/viro.1993.1499

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

433-41

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(83)71499-6

journal_volume

196

pub_type

杂志文章

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