Abstract:
:Recent studies have shown that interferon-gamma (IFN-gamma) synergizes with IFN-alpha/beta to inhibit the replication of both RNA and DNA viruses. We investigated the effects of IFNs on the replication of two strains of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). While treatment of Vero E6 cells with 100 U/ml of either IFN-beta or IFN-gamma marginally reduced viral replication, treatment with both IFN-beta and IFN-gamma inhibited SARS-CoV plaque formation by 30-fold and replication by 3000-fold at 24 h and by > 1 x 10(5)-fold at 48 and 72 h post-infection. These studies suggest that combination IFN treatment warrants further investigation as a treatment for SARS.
journal_name
Virologyjournal_title
Virologyauthors
Sainz B Jr,Mossel EC,Peters CJ,Garry RFdoi
10.1016/j.virol.2004.08.011subject
Has Abstractpub_date
2004-11-10 00:00:00pages
11-7issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(04)00542-2journal_volume
329pub_type
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