Abstract:
:Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle, the definition of its specific role and subcellular localization remains unclear. In the present work we demonstrate, using imaging techniques, that VP5 is not a type II transmembrane protein but an intracellular membrane-associated protein. This finding might provide evidences of VP5 interaction with cellular proteins and its functions.
journal_name
Virologyjournal_title
Virologyauthors
Carballeda JM,Maroniche G,Lucero MS,Richetta M,Gómez E,Chimeno Zoth S,Berinstein Adoi
10.1016/j.virol.2015.05.003subject
Has Abstractpub_date
2015-09-01 00:00:00pages
312-7eissn
0042-6822issn
1096-0341pii
S0042-6822(15)00247-0journal_volume
483pub_type
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