Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.

Abstract:

:A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed "THP-1" monocytic cells used in these studies are instead Raji B cells. Moreover, we demonstrate that true THP-1 cells do not support DC-SIGN-mediated HIV-1 transmission, whereas human B cell lines efficiently enhance this process. These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission.

journal_name

Virology

journal_title

Virology

authors

Wu L,Martin TD,Carrington M,KewalRamani VN

doi

10.1016/j.virol.2003.09.028

subject

Has Abstract

pub_date

2004-01-05 00:00:00

pages

17-23

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042682203007311

journal_volume

318

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera.

    abstract::Although it is known that Ad5-specific neutralizing antibodies (NAbs) against three major viral capsid components (hexon, penton and fiber) are generated, differences in the frequency and nature of these pre-existing NAbs remain unclear. The results emphasized the contribution of anti-fiber antibodies to Ad5 neutraliz...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2012.12.014

    authors: Yu B,Dong J,Wang C,Zhan Y,Zhang H,Wu J,Kong W,Yu X

    更新日期:2013-03-15 00:00:00

  • Sequence analysis of the phosphoprotein (P) genes of human parainfluenza type 4A and 4B viruses and RNA editing at transcript of the P genes: the number of G residues added is imprecise.

    abstract::We cloned and sequenced the cDNAs against genomic RNAs and mRNAs for phosphoproteins (Ps) of human parainfluenza virus types 4A (PIV-4A) and 4B (PIV-4B). The PIV-4A and -4B P genes were 1535 nucleotides including poly(A) tract and were found to have two small open reading frames, neither of which was apparently large ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(90)90413-l

    authors: Kondo K,Bando H,Tsurudome M,Kawano M,Nishio M,Ito Y

    更新日期:1990-09-01 00:00:00

  • Subviral agents associated with plant single-stranded DNA viruses.

    abstract::Begomoviruses (family Geminiviridae) are responsible for many economically important crop diseases worldwide. The majority of these diseases are caused by bipartite begomovirus infections, although a rapidly growing number of diseases of the Old World are associated with monopartite begomoviruses. With the exception o...

    journal_title:Virology

    pub_type: 杂志文章,随机对照试验,评审

    doi:10.1016/j.virol.2005.09.042

    authors: Briddon RW,Stanley J

    更新日期:2006-01-05 00:00:00

  • Single oral immunization with replication deficient recombinant adenovirus elicits long-lived transgene-specific cellular and humoral immune responses.

    abstract::Oral-gastric delivery of vaccines is a preferred route of immunization and is particularly relevant to the development of vaccine-vector systems. We have investigated the ability of a replication deficient (E1-deleted) adenovirus construct (RAd68), which efficiently expresses the measles virus nucleocapsid (N) protein...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.2001.1281

    authors: Sharpe S,Fooks A,Lee J,Hayes K,Clegg C,Cranage M

    更新日期:2002-02-15 00:00:00

  • Infection of bovine dendritic cells by rinderpest or measles viruses induces different changes in host transcription.

    abstract::The morbilliviruses are a closely related genus which are very similar in their sequences and share a common receptor, but nevertheless show significant restriction in the host species in which they cause disease. One contribution to this restriction might be the nature of the hosts' responses to infection. We have us...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2009.09.031

    authors: Nanda SK,Baron J,Royall E,Robinson L,Falciani F,Baron MD

    更新日期:2009-12-20 00:00:00

  • Characterization of Enterococcus faecium bacteriophage IME-EFm5 and its endolysin LysEFm5.

    abstract::Due to the worldwide prevalence of antibiotic resistant strains, phages therapy has been revitalized recently. In this study, an Enterococcus faecium phage named IME-EFm5 was isolated from hospital sewage. Whole genomic sequence analysis demonstrated that IME-EFm5 belong to the Siphoviridae family, and has a double-st...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2016.02.006

    authors: Gong P,Cheng M,Li X,Jiang H,Yu C,Kahaer N,Li J,Zhang L,Xia F,Hu L,Sun C,Feng X,Lei L,Han W,Gu J

    更新日期:2016-05-01 00:00:00

  • The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat.

    abstract::HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2013.07.024

    authors: Du J,Xue H,Ma J,Liu F,Zhou J,Shao Y,Qiao W,Liu X

    更新日期:2013-11-01 00:00:00

  • Ex vivo detection of adenovirus specific CD4+ T-cell responses to HLA-DR-epitopes of the Hexon protein show a contracted specificity of T(HELPER) cells following stem cell transplantation.

    abstract::Human adenovirus (HAdV) is a cause of significant morbidity and mortality in immunocompromised patients, especially after stem cell transplantation (SCT). Viral clearance has been attributed to CD4(+) T-cell responses against the Hexon-protein, but the frequency of specific T(HELPER) cells is extremely low or not dete...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2009.10.049

    authors: Serangeli C,Bicanic O,Scheible MH,Wernet D,Lang P,Rammensee HG,Stevanovic S,Handgretinger R,Feuchtinger T

    更新日期:2010-02-20 00:00:00

  • Common modular structure of lentivirus LTRs.

    abstract::Retroviruses are expressed under the control of viral control regions designated long terminal repeats (LTRs), which contain all signals for transcriptional initiation as well as transcriptional termination. However, retroviral LTRs from different species within a common genus, such as Lentivirus, do not show signific...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1996.0527

    authors: Frech K,Brack-Werner R,Werner T

    更新日期:1996-10-01 00:00:00

  • Mutational analysis of the coat protein gene of tobacco mosaic virus in relation to hypersensitive response in tobacco plants with the N' gene.

    abstract::Tomato strain L of tobacco mosaic virus (TMV-L) induces a hypersensitive response (necrotic local lesions) on tobacco plants with the N' gene. A factor responsible for induction of the hypersensitive response has been mapped to the coat protein gene. We have constructed several mutants which have insertions or deletio...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(89)90217-1

    authors: Saito T,Yamanaka K,Watanabe Y,Takamatsu N,Meshi T,Okada Y

    更新日期:1989-11-01 00:00:00

  • Carboxy-fluorescein diacetate, succinimidyl ester labeled papillomavirus virus-like particles fluoresce after internalization and interact with heparan sulfate for binding and entry.

    abstract::Human papillomaviruses (HPVs) infect epithelial cells and are associated with genital carcinoma. Most epithelial cell lines express cell-surface glycosaminoglycans (GAGs) usually found attached to the protein core of proteoglycans. Our aim was to study how GAGs influenced HPV entry. Using a human keratinocyte cell lin...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/s0042-6822(03)00114-4

    authors: Drobni P,Mistry N,McMillan N,Evander M

    更新日期:2003-05-25 00:00:00

  • Antigenic, sequence, and crystal variation in influenza B neuraminidase.

    abstract::The neuraminidase (NA) genes of influenza B viruses B/Maryland/59, B/Hong Kong/8/73, B/Singapore/222/79, B/Oregon/5/80, B/USSR/100/83, B/Victoria/3/85, B/Leningrad/179/86, B/Memphis/6/86, and B/Memphis/3/89 have been sequenced. The deduced amino acid sequences show high variability in the stalk domain of the NA, but a...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(90)90523-t

    authors: Air GM,Laver WG,Luo M,Stray SJ,Legrone G,Webster RG

    更新日期:1990-08-01 00:00:00

  • Viral isolates derived from simian varicella epizootics are genetically related but are distinct from other primate herpesviruses.

    abstract::Epizootics of a natural varicella-like disease occur in populations of nonhuman primates. Several primate herpesviruses have been isolated from these epizootics, but the relatedness of these isolates to each other is not well-defined. In this study, we demonstrated that the restriction endonuclease (REn) profiles of f...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1996.0517

    authors: Gray WL,Gusick NJ

    更新日期:1996-10-01 00:00:00

  • Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation.

    abstract::A pseudorabies virus (PrV) mutant, deficient in the nonessential glycoprotein E (gE) and expressing the LacZ gene (gE- beta gal+ PrV), and its rescued virus were inoculated intranasally in mice. The median lethal dose of gE- beta gal+ PrV was similar to that of the parental Kaplan strain, but mice survived longer and ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1996.0247

    authors: Babic N,Klupp B,Brack A,Mettenleiter TC,Ugolini G,Flamand A

    更新日期:1996-05-01 00:00:00

  • Deletion of pe38 attenuates AcMNPV genome replication, budded virus production, and virulence in heliothis virescens.

    abstract::The pe38 gene product of Autographa californica M nucleopolyhedrovirus (AcMNPV) has been shown to be involved in transcriptionally transactivating viral genes and augmenting viral DNA replication in transient assays. To assess the role of pe38 during infection, we generated a knockout virus, Delta pe38-E9/E9, in which...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/s0042-6822(03)00143-0

    authors: Milks ML,Washburn JO,Willis LG,Volkman LE,Theilmann DA

    更新日期:2003-06-05 00:00:00

  • In vivo analysis of the cell cycle dependent association of the bovine papillomavirus E2 protein and ChlR1.

    abstract::It has been shown that the genomes of episomally maintained DNA viruses are tethered to host cell chromosomes during cell division, facilitating maintenance in dividing cells. The papillomavirus E2 protein serves this mechanism of viral genome persistence by simultaneously associating with chromatin and the viral geno...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2011.03.015

    authors: Feeney KM,Saade A,Okrasa K,Parish JL

    更新日期:2011-05-25 00:00:00

  • Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein.

    abstract::The caprine arthritis-encephalitis (CAEV) and ovine maedi-visna (MVV) viruses are resistant to antibody neutralization, a feature shared with all other lentiviruses. Whether the CAEV gp135 receptor binding site(s) (RBS) in the functional surface envelope glycoprotein (Env) is protected from antibody binding, allowing ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2005.05.028

    authors: Hötzel I,Cheevers WP

    更新日期:2005-09-01 00:00:00

  • Characterization of the interactions among vaccinia virus transcription factors G2R, A18R, and H5R.

    abstract::Prior genetic analysis suggests that there may exist an interaction between the products of the vaccinia virus genes A18R, a putative negative transcription elongation factor, and G2R, a putative positive transcription elongation factor. In addition, affinity purification of polyhistidine-tagged G2R protein overexpres...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1998.9166

    authors: Black EP,Moussatche N,Condit RC

    更新日期:1998-06-05 00:00:00

  • Natural controlled HIV infection: preserved HIV-specific immunity despite undetectable replication competent virus.

    abstract::Long-term non-progressive HIV infection, characterized by low but detectable viral load and stable CD4 counts in the absence of antiviral therapy, is observed in about 5% of HIV-infected patients. Here we identified four therapy naïve individuals who are strongly seropositive for HIV-1 but who lack evidence of detecta...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2005.06.001

    authors: Kloosterboer N,Groeneveld PH,Jansen CA,van der Vorst TJ,Koning F,Winkel CN,Duits AJ,Miedema F,van Baarle D,van Rij RP,Brinkman K,Schuitemaker H

    更新日期:2005-08-15 00:00:00

  • Histones as a target for influenza virus matrix protein M1.

    abstract::Matrix protein M1 purified from influenza A and B viruses has been analyzed for its ability to specifically interact with cellular proteins by immune coprecipitation and by an in vitro binding assay on nitrocellulose on PVDF membranes. When M1 was mixed with lysates of uninfected cells there was selective binding of h...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1997.8700

    authors: Zhirnov OP,Klenk HD

    更新日期:1997-09-01 00:00:00

  • The RING finger domain of the varicella-zoster virus open reading frame 61 protein is required for its transregulatory functions.

    abstract::Varicella-zoster virus (VZV) open reading frame 61 (ORF61) protein transactivates expression of VZV promoters. VZV ORF61 is functionally homologous to herpes simplex virus type 1 (HSV-1)-infected cell protein 0 (ICP0); however, amino acid sequence homology of these two proteins is limited to the RING finger domains, a...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1994.1639

    authors: Moriuchi H,Moriuchi M,Cohen JI

    更新日期:1994-11-15 00:00:00

  • Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS.

    abstract::In genetically susceptible C57BL/6 mice the LP-BM5 isolate of murine retroviruses causes profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, and an immunodeficiency syndrome bearing many similarities to the pathologies seen in AIDS. Because of these similarities, which also include terminal B cell lymphoma...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1006/viro.1997.8970

    authors: Green KA,Noelle RJ,Green WR

    更新日期:1998-02-15 00:00:00

  • Characterization of the core promoter and enhancer of duck hepatitis B virus.

    abstract::The core gene promoter of duck hepatitis B virus (DHBV) has been localized and an enhancer element has been found in a region of the DHBV genome immediately upstream of the core promoter. This enhancer was able to activate expression from both the core promoter and the S promoter of DHBV, as well as from the heterolog...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(91)90841-x

    authors: Liu C,Condreay LD,Burch JB,Mason W

    更新日期:1991-09-01 00:00:00

  • Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain.

    abstract::An essential step for a productive infection by the dengue flavivirus (DEN) is translation of the m(7)G-capped, nonpolyadenylated positive-sense RNA genome. We have recently identified sequences within the DEN 3' untranslated region (UTR) that modulate viral translation. Here, we show that the DEN type 2 (DEN2) 3'UTR ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2004.08.004

    authors: Holden KL,Harris E

    更新日期:2004-11-10 00:00:00

  • Glycosylation of the cauliflower mosaic virus capsid polypeptide.

    abstract::Evidence is presented for the glycosylation of the cauliflower mosaic virus (CaMV) capsid polypeptide. Fluorescent derivatives of concanavalin A (Con A) were shown to bind specifically to the dissociated CaMV capsid polypeptides in polyacrylamide gels. Con A also bound specifically to intact CaMV, so inhibiting the at...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(81)90510-9

    authors: Du Plessis DH,Smith P

    更新日期:1981-03-01 00:00:00

  • The nectin-1alpha transmembrane domain, but not the cytoplasmic tail, influences cell fusion induced by HSV-1 glycoproteins.

    abstract::Nectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superfamily, and a cellular adhesion molecule. To study domains of nectin-1alpha involved in cell fusion, we measured the ability of nectin-1alpha/nectin-2alpha chimeras, nectin-1alpha/CD4 chimeras, and transmembrane domain and cytop...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2005.05.031

    authors: Subramanian RP,Dunn JE,Geraghty RJ

    更新日期:2005-09-01 00:00:00

  • Lineage structures in the genome sequences of three Epstein-Barr virus strains.

    abstract::Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were ident...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2006.10.009

    authors: McGeoch DJ,Gatherer D

    更新日期:2007-03-01 00:00:00

  • Amino acid sequence analysis of bovine rotavirus B223 reveals a unique outer capsid protein VP4 and confirms a third bovine VP4 type.

    abstract::The nucleotide and deduced amino acid sequence of the gene 4 of bovine rotavirus strain B223 is described. The open reading frame is predicted to encode a VP4 of 772 amino acids, shorter than described for any other rotavirus strain sequenced to date. B223 VP4 shows 70 to 73% similarity to other rotavirus VP4 proteins...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(92)90191-q

    authors: Hardy ME,Gorziglia M,Woode GN

    更新日期:1992-11-01 00:00:00

  • Selective integration of avian leukosis virus in different hematopoietic tissues.

    abstract::Hematopoietic tissues obtained from avian leukosis virus (ALV)-infected Hyline SC chickens were analyzed for the presence of integrated viral DNA sequences. Cells were prepared from bone marrow, bursa, spleen, thymus, and peripheral blood. Following the removal of erythrocytes, cellular DNAs from each of these tissues...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(86)90216-3

    authors: Baba TW,Humphries EH

    更新日期:1986-12-01 00:00:00

  • Absence of transcriptase activity or transcription-inhibiting ability in defective interfering particles of vesicular stomatitis virus.

    abstract::Defective interfering particles of New Jersey serotype VSV were found to contain very little or no virion transcriptase activity. Furthermore no VSV transcriptase activity was observed in cells treated with cycloheximide and infected with DI. Cells infected with DI together with standard infectious virus and cyclohexi...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/0042-6822(72)90356-x

    authors: Perrault J,Holland JJ

    更新日期:1972-10-01 00:00:00