Abstract:
:Retroviruses can be grouped by viral interference measurements into classes which use common cell surface receptors. We previously tested a large number of isolates of mink cell focus-inducing (MCF) murine leukemia viruses (MuLVs), and reported that all of them share a distinct receptor on NIH/3T3 cells (A. Rein, Virology 120, 251, 1982). We now extend this generalization to several additional recombinant isolates, including two (SL3-2 and GPA-V2) which would not be considered MCFs on the basis of host-range data. We note the superiority of interference tests, based on positive, unambiguous data, over host-range tests for virus classification. We also show that in contrast to the MCFs, which are all derived from ecotropic MuLVs, a recombinant derived from wild mouse amphotropic MuLV (S. Rasheed et al., Int. J. Cancer 29, 345, 1982) uses a unique receptor on NIH/3T3 cells. This suggests that (a) mouse cells contain more than one type of endogenous env sequence; and (b) there is some specificity in the generation of recombinants, since ecotropic MuLVs appear to give rise only to MCFs, while amphotropic MuLV has generated a distinct type of recombinant. It also represents a second case (in addition to the MCFs) in which an env gene recombinant is more pathogenic than its exogenous parent. We also show that xenotropic MuLV does not interfere with MCFs in NZB mouse cells; thus, despite the close homology between MCF and xenotropic env sequences, the gp70 of xenotropic MuLV appears to have no detectable affinity for the MCF receptor.
journal_name
Virologyjournal_title
Virologyauthors
Rein A,Schultz Adoi
10.1016/0042-6822(84)90255-1subject
Has Abstractpub_date
1984-07-15 00:00:00pages
144-52issue
1eissn
0042-6822issn
1096-0341journal_volume
136pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Highly pathogenic alphaviruses display complex glycans on their surface. These glycans play a crucial role in viral pathogenesis by facilitating glycan-host interaction during viral entry which can be targeted. Various studies have reported antiviral activity of lectins that bind to the glycans present on the surface ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.009
更新日期:2019-01-02 00:00:00
abstract::SIV/Mne circle junctions were amplified by the polymerase chain reaction (PCR) and cloned in a bacterial plasmid. Sequence analysis of clones isolated from 11 independent PCRs reveals that the start site for plus DNA synthesis is 5' ACTG. . ., and thus an asymmetric cleavage must occur during viral integration. In add...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1329
更新日期:1993-06-01 00:00:00
abstract::Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) caused a severe outbreak in several regions of the world in 2003. The SARS-CoV genome is predicted to contain 14 functional open reading frames (ORFs). The first ORF (1a and 1b) encodes a large polyprotein that is cleaved into nonstructural proteins (nsp)...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.04.029
更新日期:2007-09-30 00:00:00
abstract::A class of disulfide constrained peptides containing a core motif FPWG was identified from a screen of phage displayed library using the HCV RNA-dependent RNA polymerase (NS5B) as a bait. Surface plasmon resonance studies showed that three highly purified synthetic constrained peptides bound to immobilized NS5B with e...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00313-1
更新日期:2003-08-15 00:00:00
abstract::Avian myelocytomatosis virus MC29 inoculated into the wing web of 1-day-old Brown Leghorn chickens causes a high incidence of tumors, predominantly endotheliomas that are apparently induced directly by the action of the viral myc gene. Mutants of MC29, in which portions of the v-myc gene have been deleted and which ha...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(83)90300-8
更新日期:1983-01-15 00:00:00
abstract::The HIV-2 viral accessory protein Vpx is related to, but distinct from the Vpr protein of HIV-1. Vpx is packaged into virions and as a component of the viral preintegration complex (PIC) is required for efficient virus replication in non-dividing cells. We have previously reported that the minimal transferable region ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.10.036
更新日期:2006-03-01 00:00:00
abstract::Genetic variation in dengue 2 isolates from various geographic areas was examined by oligonucleotide fingerprinting of the 40 S genome RNA. Oligonucleotide maps of geographically isolated and epidemiologically unrelated viruses were very distinct. Direct comparison of the oligonucleotide map of the dengue 2 prototype ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(83)90255-6
更新日期:1983-07-30 00:00:00
abstract::Although herpesviruses have a wide host range and their genomes vary substantially in size, the nucleocapsid appears to be a conservative element of viral design. The capsid shell is icosahedrally symmetric (T = 16), and 125 nm in diameter and 15nm thick in the case of herpes simplex virus 1 (HSV-1). Channel catfish v...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0016
更新日期:1996-01-15 00:00:00
abstract::Structure-guided approaches to HIV-1 vaccine design depend on knowledge of the presentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAb b12. Here, we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.06.024
更新日期:2012-10-25 00:00:00
abstract::The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several key cellular functions including protein synthesis, cell growth, glucose metabolism, and inflammation. Many viruses have evolved mechanisms to manipulate this signaling pathway to ensure successful virus replication. The human herpesvirus...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2015.02.040
更新日期:2015-05-01 00:00:00
abstract::In wild-type human parainfluenza virus type 2 (WT HPIV2), one gene (the P/V gene) encodes both the polymerase-associated phosphoprotein (P) and the accessory V protein. We generated a HPIV2 virus (rHPIV2-V(ko)) in which the P/V gene encodes only the P protein to examine the role of V in replication in vivo and as a po...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.11.018
更新日期:2010-02-20 00:00:00
abstract::Chimeric proteins consisting of the VP2 capsid protein of human parvovirus B19 and defined linear epitopes from human herpes simplex virus type 1 and mouse hepatitis virus A59 inserted at the N-terminus and at a predicted surface region were expressed by recombinant baculoviruses. The chimeric proteins expressed the i...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1059
更新日期:1994-02-01 00:00:00
abstract::Previous studies have shown that a 558-bp fragment of human cytomegalovirus (CMV) DNA contained within pCM4127 and designated CMV mtr can morphologically transform rodents cells in vitro. By cotransformation with pCM4127 and a plasmid conferring G418 resistance, pSV2neo, morphologically transformed NIH3T3 cell lines w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90437-5
更新日期:1987-01-01 00:00:00
abstract::At high concentrations, several monoclonal antibodies to the G1 glycoprotein of La Crosse (LAC) virus aggregated the virus. To determine whether this accounted for the neutralization, the monoclonal antibodies were digested to make Fab fragments. With one exception, each monovalent antibody neutralized LAC virus to th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90073-k
更新日期:1991-02-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) glycoproteins K and B (gK and gB) are intimately involved in virus-induced fusion of cells. Certain mutations in the UL27 (gB) and UL53 (gK) genes confer a syncytial (syn) phenotype characterized by extensive fusion of infected cells and giving rise to multinucleated cells. We have ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1507
更新日期:1993-10-01 00:00:00
abstract::The 85-kDa polypeptide previously shown to be associated with the restricted (R) component of the EBV-induced early antigen (EA) complex was subjected to amino acid sequencing analysis. This was accomplished by cyanogen bromide cleavage and by separation of individual peptides by high-pressure liquid chromatography em...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90331-x
更新日期:1987-03-01 00:00:00
abstract::The surface of the mature dengue virus (DENV) particle consists of 90 envelope (E) protein dimers that mediate both receptor binding and fusion. The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralizat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.05.042
更新日期:2007-09-30 00:00:00
abstract::Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.04.001
更新日期:2006-08-01 00:00:00
abstract::Bipartite geminiviruses are small, plant-infecting viruses with genomes composed of circular, single-stranded DNA molecules, designated A and B. Although they are closely related genetically, individual bipartite geminiviruses frequently exhibit host-specific adaptation. Two such viruses are bean golden mosaic virus (...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0620
更新日期:2000-11-25 00:00:00
abstract::We have utilized glycan microarray technology to determine the receptor binding properties of early isolates from the recent 2009 H1N1 human pandemic (pdmH1N1), and compared them to North American swine influenza isolates from the same year, as well as past seasonal H1N1 human isolates. We showed that the pdmH1N1 stra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.01.027
更新日期:2011-05-10 00:00:00
abstract::Powassan virus (POWV, Flaviviridae: Flavivirus) is the sole North American member of the tick-borne encephalitis complex and consists of two distinct lineages that are maintained in ecologically discrete enzootic transmission cycles. The underlying genetic mechanisms that lead to niche partitioning in arboviruses are ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.03.035
更新日期:2010-07-05 00:00:00
abstract::Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we describe the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.08.030
更新日期:2019-11-01 00:00:00
abstract::Two small viral proteins (DGBp1 and DGBp2) have been proposed to act in a concerted manner to aid intra- and intercellular trafficking of carmoviruses though the distribution of functions and mode of action of each protein partner are not yet clear. Here we have confirmed the requirement of the DGBps of Pelargonium fl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.001
更新日期:2011-05-10 00:00:00
abstract::Although H5N1 influenza viruses have been responsible for hundreds of human infections, these avian influenza viruses have not fully adapted to the human host. The lack of sustained transmission in humans may be due, in part, to their avian-like receptor preference. Here, we have introduced receptor binding domain mut...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.02.015
更新日期:2011-04-25 00:00:00
abstract::We have cloned an infectious genome of the Junonia coenia densonucleosis virus (JcDNV) into the bacterial plasmid pBR322. The viral genome could be rescued from the recombinant plasmid pBRJ by transfection of pBRJ DNA to sensitive Spodoptera littoralis larvae. pBRJ DNA produced a typical viral infection and a comparab...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90308-e
更新日期:1990-11-01 00:00:00
abstract::Three cDNA clones that express viral gene products in Escherichia coli JM83 were derived from a watermelon mosaic virus-1 strain of papaya ringspot virus (PRSV-W). DNAs complementary to portions of the viral RNA were inserted into the pUC8 and pUC9 plasmids, and the expressed polypeptides were fusion products with the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90383-6
更新日期:1985-06-01 00:00:00
abstract::In a previous study, we observed that hepatitis C virus (HCV) core protein specifically inhibits translation initiated by an HCV internal ribosome entry site (IRES). To investigate the mechanism by which down-regulation of HCV translation occurs, a series of mutations were introduced into the IRES element, as well as ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.10.013
更新日期:2006-02-20 00:00:00
abstract::We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV resistance, compared to either single mutant. Unexpectedly, K101E+G190S also repli...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.03.018
更新日期:2010-07-05 00:00:00
abstract::We have previously reported that a novel herpes simplex virus RNA transcript partially overlapping the gene encoding ICPO and expressed from the opposite DNA strand is abundant in sensory neurons of mice harboring a latent infection [J.G. Stevens, E.K. Wagner, G.B. Devi-Rao, M.L. Cook, and L.T. Feldman, Science 235, 1...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90169-9
更新日期:1988-09-01 00:00:00
abstract::A cDNA clone containing all of the 26 S mRNA coding region of the RNA genome of Venezuelan equine encephalitis (VEE) virus, virulent strain Trinidad donkey (TRD), has been constructed and sequenced. The nucleotide and deduced amino acid sequences of the 26 S RNA of VEE virus conform to the general organization of the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(86)90142-x
更新日期:1986-07-30 00:00:00