Abstract:
:We have utilized glycan microarray technology to determine the receptor binding properties of early isolates from the recent 2009 H1N1 human pandemic (pdmH1N1), and compared them to North American swine influenza isolates from the same year, as well as past seasonal H1N1 human isolates. We showed that the pdmH1N1 strains, as well as the swine influenza isolates examined, bound almost exclusively to glycans with α2,6-linked sialic acid with little binding detected for α2,3-linked species. This is highlighted by pair-wise comparisons between compounds with identical glycan backbones, differing only in the chemistry of their terminal linkages. The overall similarities in receptor binding profiles displayed by pdmH1N1 strains and swine isolates indicate that little or no adaptation appeared to be necessary in the binding component of HA for transmission from pig to human, and subsequent human to human spread.
journal_name
Virologyjournal_title
Virologyauthors
Bradley KC,Jones CA,Tompkins SM,Tripp RA,Russell RJ,Gramer MR,Heimburg-Molinaro J,Smith DF,Cummings RD,Steinhauer DAdoi
10.1016/j.virol.2011.01.027subject
Has Abstractpub_date
2011-05-10 00:00:00pages
169-82issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(11)00041-9journal_volume
413pub_type
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